Effects of calcitonin and alendronate on distraction osteogenesis

Şen, Cengiz; Güneş, Taner; Erdem, Mehmet; Köseoğlu, Reşit Doğan; Filiz, Nurper Onuk

doi:10.1007/s00264-005-0048-9

Cited by 27 publications

(24 citation statements)

References 23 publications

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“…Many attempts have been made to shorten the bone consolidation period during DO, including low-intensity pulsed ultrasound, 25 recombinant growth hormone, 26 intermittent parathyroid hormone, 27 calcitonin and alendronate, 28 calcium sulfate, 29 and growth factors such as BMPs and IGF. 30,31 In the present study, locally applied hNGFb accelerated callus maturation of a distraction gap in a rabbit mandibular distraction model.…”

Section: Discussionmentioning

confidence: 99%

Locally applied nerve growth factor enhances bone consolidation in a rabbit model of mandibular distraction osteogenesis

et al. 2006

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Distraction osteogenesis is widely used in treating deformities, defects, and fractures of both long bones and craniofacial bones. Demands for acceleration of bone consolidation are increased in distraction osteogenesis. Nerve growth factor (NGF) can enhance innervation and bone regeneration in a fracture model and stimulate differentiation of osteoblastic cells. In this study, we tested the ability of locally applied NGF to enhance bone regeneration in a rabbit model of mandibular distraction osteogenesis. Twenty rabbits underwent bilateral distraction osteogenesis with a rate of 0.5 mm per 12 h. Two times 0.04 mg human NGFb (hNGFb) in buffer was injected into the callus after distraction. The contralateral side received placebo injections. Rabbits were euthanized at consolidation times of 14 and 28 days. Specimens were subjected to radiography, callus dimensions measurement, mechanical testing, and bone histological and histomorphometric analysis. The maximum load, bone volume/total volume, mineral apposition rate of the 1st to 11th day, and mineralized bone percentage were significantly higher in the hNGFb side at 14 and 28 days (p < 0.05). The data indicate that locally applied hNGFb can accelerate callus maturation and may be an option to shorten the consolidation period in distraction osteogenesis. ß

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Section: Discussionmentioning

confidence: 99%

Locally applied nerve growth factor enhances bone consolidation in a rabbit model of mandibular distraction osteogenesis

et al. 2006

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“…For that reason, in the present study, numerous approaches were researched to accelerate the maturation of the regenerate bone including growth factors 15 , hormones 12,23 , calcium sulphate 2 , and electronic 10 and ultrasonic 22 stimulation. In recent studies, bisphosphonates 8,20,24 were indicated to be efficient in hastening bone regeneration.…”

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confidence: 99%