Effects of Calcitonin, Calcitonin Gene-Related Peptide, Human Recombinant Bone Morphogenetic Protein-2, and Parathyroid Hormone–Related Protein on Endodontically Treated Ferret Canines

Potential Characteristics of Stem Cells from Human Exfoliated Deciduous Teeth Compared with Bone Marrow–derived Mesenchymal Stem Cells for Mineralized Tissue-forming Cell Biology

“…This finding is consistent with BMPs acting via activation of the mitogen-activated protein kinase (MAPK) or JNK pathways (30). Moreover, BMP-2, which was reported to have an inductive effect in osteogenesis and dentinogenesis (22,23), was used in this study to stimulate the BMP signaling pathway. After BMP-2 stimulation, the expression levels of osteogenic/odontogenicrelated genes increased in both SHED and BMMSCs ( Fig.…”

“…BMPs also stimulate differentiation of osteoblasts and odontoblasts and of mineralization via the BMP signaling pathway. Among them, it is known that BMP-2 acts in a paracrine fashion in concert with other BMPs and induces to stimulate bone or osteodentin formation (20)(21)(22)(23). BMP-4 also accelerates cell differentiation in similar fashion to BMP-2 (17,24,25).…”

Dentinogenic capacity: immature root papilla stem cells versus mature root pulp stem cells

“…During the root development, dental root papilla stem cells mainly contribute to the active dentin formation (primary dentinogenesis) and root maturation (Sonoyama et al, 2008; Huang et al, 2009). After the root formation, adult root pulp stem cells are relatively quiescent in a healthy tooth or bring about the tertiary dentinogenesis in response to pathological stimuli, including the mechanical abrasion, erosion, trauma and carious lesions (Goldberg and Smith, 2004; Tziafas, 2004; Sloan and Smith, 2007; Kline and Yu, 2009; Tziafas and Kodonas, 2010). Thus, it is reasonable that iRPSCs and mRPSCs may have distinguishable dentinogenic features corresponding to different developmental stages.…”

Inflammation–regeneration interplay in the dentine–pulp complex

“…Indeed SP, CGRP, VIP and NPY may represent novel regulators of pulpal angiogenic events whilst CGRP and CT stimulated osteodentin deposition in ferret canines. 77,78 Clearly, further work is required in the study of this interesting class of molecules.…”