Effects of Calcitonin, Risedronate, and Raloxifene on Erythrocyte Antioxidant Enzyme Activity, Lipid Peroxidation, and Nitric Oxide in Postmenopausal Osteoporosis

Özgöçmen, Salih; Kaya, Hüseyin; Fadıllıoğlu, Ersin; Yilmaz, Zumrut

doi:10.1016/j.arcmed.2006.09.010

Cited by 63 publications

(50 citation statements)

References 40 publications

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“…The current investigation showed a relation between osteoporosis and ROS generation, since the OVX rats showed a significant elevation of MDA level and significant decrease of GPx, SOD and TAC activities. These results are in agreement with Sontakke and Tare (2002) and Ozgocmen et al (2007). Yalin et al (2005) illustrated that SOD, CAT and GPx are the major enzymatic antioxidants involved in the protection against O 2 •− and H 2 O 2 .…”

Section: Discussionsupporting

confidence: 86%

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Sayed¹,

Soliman²,

Fahmy³

et al. 2013

Afr. J. Pharm. Pharmacol.

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The efficacy of Coelatura aegyptiaca shell powder (CES, 500 mg/kg BW) was evaluated as a calcium supplement in ovariectomized (OVX) rats for ten weeks of treatment. The biochemical components and the antioxidant properties of the shell powder were determined. The bone mineral density (BMD), bone mineral content (BMC), calcium (Ca) and phosphorus (P) contents in serum and bone, serum total alkaline phosphatase (TALP) and bone alkaline phosphatase (BALP), serum calcitonin and parathyroid (PTH) hormones were determined. Furthermore, some of the oxidative stress markers [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant capacity (TAC)] were estimated in bone. The current study revealed that CES contained 19.38% Ca, 0.315% P as well as some of antioxidant amino acids which have a potent antioxidant activity against 1,1-diphenylpicrylhydrazyl (DPPH) free radical. Administration of CES to OVX rats increased BMD, BMC, tibial Ca and P contents and BALP activity, as compared to OVX rats. An ameliorative effect was recorded in the levels of calcitonin, PTH, MDA, SOD, GPx and TAC subsequent to CES administration to OVX rats.This ameliorative effect of CES powder against osteoporosis may be attributed to its antioxidant efficacy and/or to its Ca content. In conclusion, CES may have the potential to develop a clinically useful anti-osteoporotic agent, since its effect was comparable with alendronate (6.5 mg/kg BW/week).

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Section: Discussionsupporting

confidence: 86%

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Sayed¹,

Soliman²,

Fahmy³

et al. 2013

Afr. J. Pharm. Pharmacol.

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“…Although DF is well known for its analgesic and anti-inflammatory properties [33], its adverse effects have also been equally reported [37]. Sct abets lipid peroxidation, and therefore has a favourable effect on the endogenous antioxidant system [38]. Unlike Sct, there are incongruent reports about the effect of N-3 on oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Effects of single or combined administration of salmon calcitonin and omega-3 fatty acids vs. diclofenac sodium in sodium monoiodoacetate-induced knee osteoarthritis in male Wistar rats

Adeyemi

Olayaki

2017

Journal of Basic and Clinical Physiology and Pharmacology

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Background: There is a continuous search for a better therapy in osteoarthritis (OA) management. Therefore, this study investigated the effects of salmon calcitonin (Sct) and/or omega-3 fatty acids (N-3) relative to diclofenac sodium (DF) in induced knee osteoarthritic male Wistar rats. Methods:The 40 rats that were used in this study were divided into 8 groups (n = 5 rats), viz: Normal control; OA control; OA + N-3; OA + Low dose of Sct (Sct.Lw); OA + High dose of Sct (Sct.Hi); OA + N-3 + SCt.Lw; OA + N-3 + Sct.Hi; and, OA + DF. OA was induced with 4 mg of sodium monoiodoacetate in 40 μL of saline. The solution was injected into the left knee joint space of anaesthetised rats. Sct was administered at 2.5 and 5.0 IU/kg b.w. (im), whereas N-3 and DF were administered at 200 and 1 mg/kg b.w. (p.o.), respectively. Treatments commenced 9 days after the induction of OA, and they lasted for 28 days. Results: Sct and/or N-3 significantly reduced c-telopeptide of type 1 collagen (CTX-1), collagen type 2 α-1 (C2M), malondialdehyde (MDA), uric acid (UA), and interleukin-6 (IL-6), but, significantly increased superoxide dismutase (SOD) after OA induction. Both therapies had additive effects on C2M, MDA, SOD, and catalase (CAT), but, nonadditive actions on UA, IL-6, and CTX-1. Like the Sct and N-3, DF significantly reduced CTX-1, C2M, UA, and IL-6. However, it had no significant effect on SOD and MDA, even though it significantly reduced CAT activity. None of the therapies had significant effect on total alkaline phosphatase activity, except N-3 + Sct.Lw. Conclusions:The combined, and sometimes the single administration of Sct and N-3 proved to be better therapies in OA management than DF.

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“…Oxidative stress has played a part in the development of osteoporosis 26 . Reactive oxygen species has oxygen-containing molecules that are produced during normal metabolism.…”

Section: Discussionmentioning

confidence: 99%

Type ii osteoporosis pathogenesis as a result of secondary edentulous

Oleksiy¹,

Vitaliy²,

Yevhen³

et al. 2017

Bangladesh J Med Sci

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Purpose:The main sign of osteoporosis is a significant decrease of bone mass that is caused by imbalance between resorption and osteogenesis. There are two main factors that contribute to the genesis of this illness. All these factors bring todecrease of thickness of bone and its destruction doesn't depend on their combination. Therefore, our objective was to study the changes in the alveolar bones of elderly people in secondary edentulous. Material and Methods: For deeper study of morphological changes in segments of teeth we have conducted pathological researches of biopsy material of dead patients at the Center of Pathological Studies of the Sumy Medical University. The first group of patients included n=7 who died of various somatic abnormalities and had no significant atherosclerotic lesions. The second group includes segments of teeth and jaws of patients n=7 who died from complications of atherosclerosis In our studies, we used: Histological study; Fluorescence microscopy; Immunohistochemistry; Microphotography and image analysis; Mathematical calculations. Results: Based on the statistical analysis we can see a downward trend in the number of osteocytes in trabeculae of the periapical third part of the tooth at atherosclerosis 26.85±7.44; P=0.05. We can also see the dependence of trabecular thinning of toothless area of the alveolar bone 226.57±70.53; P=0.02 from losing of teeth against the background of atherosclerosis with hypertension. The osteopontin expression and fluorescencetion of toothless bone area also tend to decrease in atherosclerosis and hypertension 42.81±16.24; P=0.048. Conclusion: The cause of tooth loss is difficult to determine, since it is not clear whether it is due to osteoporosis or some forms of periodontitis in patients. The bone resorption has actived by reactive oxygen species both during atherosclerosis. Through our research found out that in order to reduce changes in the toothless bone we should reduce the pressure on chewing toothless alveolar sprout by dental implants.

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Effects of Calcitonin, Risedronate, and Raloxifene on Erythrocyte Antioxidant Enzyme Activity, Lipid Peroxidation, and Nitric Oxide in Postmenopausal Osteoporosis

Cited by 63 publications

References 40 publications

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Effects of single or combined administration of salmon calcitonin and omega-3 fatty acids vs. diclofenac sodium in sodium monoiodoacetate-induced knee osteoarthritis in male Wistar rats

Type ii osteoporosis pathogenesis as a result of secondary edentulous

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