Effects of Calcium and Vitamin D Co-supplementation on the Lipid Profile: A Systematic Review and Meta-analysis

Morvaridzadeh, Mojgan; Agah, Shahram; Alibakhshi, Pooya; Heydari, Hafez; Hoseini, Ava Sadat; Palmowski, Andriko; Toupchian, Omid; Abdollahi, Shima; Rezamand, Gholamreza; Heshmati, Javad

doi:10.1016/j.clinthera.2021.07.018

Cited by 14 publications

(11 citation statements)

References 63 publications

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“…Further, vitamin D can positively affect lipid profile by increasing calcium absorption (Reid, 2004). Indeed, Morvaridzadeh et al. (2021) reported that co-supplementation of vitamin D and calcium positively affects TG, TC and HDL-C.…”

Section: Discussionmentioning

confidence: 99%

The effects of vitamin D and omega-3 co-supplementation on lipid profile in adults: a systematic review and meta-analysis

Zamani,

Sohrabi,

Aghakhani

et al. 2024

NFS

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Purpose Previous research indicates that vitamin D and omega-3 co-supplementation may benefit overall health, but current evidence regarding its effects on lipid profile remains unclear. The present systematic review and meta-analysis aimed to examine the effects of vitamin D and omega-3 co-supplementation on lipid profile (total cholesterol [TC], low-density lipoprotein [LDL], triglyceride [TG] and high-density lipoprotein [HDL]) in adults. Design/methodology/approach In this systematic review and meta-analysis, relevant studies were obtained by searching the PubMed, Scopus and Web of Science databases (from inception to January 2022). Weighted mean differences and 95% confidence intervals were estimated via a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods. Findings Pooled analysis of six randomized controlled trials (RCTs) revealed that vitamin D and omega-3 co-supplementation yielded significant reductions in TG (p = 0.631). A pooled analysis of five trials indicated a significant association between omega-3 and vitamin D treatment and reductions in TC (p = 0.001) and LDL (p = 0.001). Although, pooled analyses of omega-3 and vitamin D did not significantly affect HDL. Originality/value The findings suggest that vitamin D and omega-3 co-supplementation lowers TG, TC and LDL in adults. Future, large-scale, RCTs on various populations are needed to elucidate further beneficial effects of vitamin D and omega-3 co-supplementation on lipid profile and establish guidelines for clinical practice.

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Section: Discussionmentioning

confidence: 99%

The effects of vitamin D and omega-3 co-supplementation on lipid profile in adults: a systematic review and meta-analysis

Zamani,

Sohrabi,

Aghakhani

et al. 2024

NFS

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show abstract

“…Another study analyzed patients with chronic kidney disease and found a reduction in total cholesterol and triglycerides in patients treated with vitamin D and no effect on HDL and LDL [ 130 ]. When considering the general population, only three meta-analyses found an effect of supplementation on increasing HDL-cholesterol levels [ 131 , 132 , 133 ], although one of these found the effect only in patients treated for more than 26 weeks [ 133 ]. Three other studies observed a correlation between vitamin D supplementation and reduction in triglyceride levels, while two observed a correlation between vitamin D administration and reduced total cholesterol [ 131 , 133 , 134 ].…”

Section: Vitamin D and Erectile Dysfunction: Relationship With Hyperc...mentioning

confidence: 99%

“…When considering the general population, only three meta-analyses found an effect of supplementation on increasing HDL-cholesterol levels [ 131 , 132 , 133 ], although one of these found the effect only in patients treated for more than 26 weeks [ 133 ]. Three other studies observed a correlation between vitamin D supplementation and reduction in triglyceride levels, while two observed a correlation between vitamin D administration and reduced total cholesterol [ 131 , 133 , 134 ]. Finally, three meta-analyses observed the effects of LDL reduction in patients treated with vitamin D [ 133 , 134 , 135 ], although, in one of these, the reduction was observed only in patients treated with a daily dose of vitamin D greater than 400 IU [ 133 ].…”

Section: Vitamin D and Erectile Dysfunction: Relationship With Hyperc...mentioning

confidence: 99%

Mechanisms Suggesting a Relationship between Vitamin D and Erectile Dysfunction: An Overview

et al. 2023

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Vitamin D deficiency (VDD) and erectile dysfunction (ED) heavily burden the male population. The higher prevalence of both conditions in the elderly suggests a possible relationship between the two conditions. In addition, in vitro, animal, and human studies have revealed several mechanisms that may relate VDD to ED. The main mechanism by which vitamin D might exert its action on sexual function appears to be through the regulation of endothelial function. Indeed, VDD correlates with several markers of endothelial function. The action of vitamin D on the endothelium would be exercised both indirectly through its intervention in inflammatory processes and through the production of oxygen free radicals, and directly through the regulation of vascular stiffness, the production of nitric oxide, and the regulation of vessel permeability. Furthermore, the ubiquitous distribution of the vitamin D receptor in the human body means that this hormone can also exert a beneficial effect on erectile function by interfering with those comorbidities significantly associated with ED, such as hypertension, diabetes mellitus, hypercholesterolemia, chronic kidney disease, and hypogonadism. In this review, we thoroughly and carefully presented the evidence and mechanisms that would appear to relate vitamin D levels to erectile function. Furthermore, we have summarized the meta-analytic evidence for and against this association to provide a true representation of this topic. Data published to date suggest that low levels of vitamin D could contribute to worsening erectile function through several mechanisms. Therefore, vitamin D levels should be measured in patients with ED and maintained at adequate levels by specific supplementation in case of deficiency. However, the low quality and heterogeneity of clinical trials evaluating the effects of vitamin D administration on erectile function and ED-associated comorbidities do not allow for a univocal conclusion, and indicate the need for further studies to analyze these aspects.

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“…Cholecalciferol (Vitamin D3) is a native vitamin D obtained by food ingestion that has various roles in the metabolism of the musculoskeletal, respiratory, endocrine, renal, cardiovascular, and immune systems J Pharm Sci Clin Res, 2024, 01 34 (Sosa andGómez, 2020). Previous scoping studies have analyzed the effect of vitamin D on lipid profiles, which found that vitamin D and calcium have a beneficial effect on total cholesterol (TC), triglycerides (TG), and HDL-C using placebo-controlled randomized controlled trials (RCTs) (Morvaridzadeh et al, 2021). Another review found that vitamin D administration in postmenopausal women reduces triglycerides, but LDL-C, HDL-C, and TC changes are negligible (Zhang et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Cholecalciferol Effects on Lipid Profile of Experimental Animals: A Scoping Review

Veonika,

Wiboworini,

Muthmainah

2024

J. Pharm. Sci. Clin. Res.

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Vitamin D is an essential nutrient that has various beneficial effects on the human body. The results of cholecalciferol supplementation are varied, and there has yet to be a comprehensive review regarding its effect on animal models. Therefore, this scoping review aims to summarize the evidence regarding the effect of cholecalciferol (vitamin D3) supplementation on the lipid profiles of animal subjects. PubMed, Scopus, and DOAJ were searched for original research articles published until 2022. Studies were included if they were experimental studies, cholecalciferol was used as a supplement, and the changes in the lipid profile were analyzed. A total of 260 articles were collected, of which 250 articles were excluded, and 10 articles were included for qualitative synthesis. All studies used oral routes to supplement cholecalciferol with various doses and duration ranging from several weeks to several months. Most studies reported reduced lipid parameters in serum or organ-specific animals supplemented with cholecalciferol. As conclusion, cholecalciferol reduces lipid content in animal subjects and may have a beneficial effect on populations with metabolic diseases such as diabetes and dyslipidemia. Further research is required to explore the mechanism of how cholecalciferol affects the lipid profiles of experimental animals.

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Effects of Calcium and Vitamin D Co-supplementation on the Lipid Profile: A Systematic Review and Meta-analysis

Cited by 14 publications

References 63 publications

The effects of vitamin D and omega-3 co-supplementation on lipid profile in adults: a systematic review and meta-analysis

The effects of vitamin D and omega-3 co-supplementation on lipid profile in adults: a systematic review and meta-analysis

Mechanisms Suggesting a Relationship between Vitamin D and Erectile Dysfunction: An Overview

Cholecalciferol Effects on Lipid Profile of Experimental Animals: A Scoping Review

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