Effects of Calcium dobesilate on horses with an increased signal intensity in the navicular bone in fat suppressed images on MRI: Pilot study

Janssen, İmke; Mair, T. S.; Reardon, Richard; Weaver, Martin; Fricker, C; Kremer, Felina; Lischer, Christoph

doi:10.21836/pem20110605

Cited by 8 publications

(2 citation statements)

References 30 publications

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“…Da knochenödem-ähnliche Veränderungen aber durch eine gesteigerte Osteoklastenaktivität ausgelöst werden können, erscheint die Anwendung von Biphosphonaten durchaus sinnvoll. Janssen et al (2012) (Hofmann et al 1993). Eine deutliche Verbesserung der Belastung bzw.…”

Section: Dieunclassified

Bone oedema like lesion of the second phalanx causing a non-weight bearing lameness in a 4 years old Trakehnen mare

Helweg¹,

Metzemacher²,

Schulze³

et al. 2014

PHK

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Bone marrow oedema like lesions (BMELLs) are described in both human athletes and sport horses. Most commonly runners and track and field athletes are affected. BMELLs are described in young military recruits at the beginning of their training, too. While all kinds of sport horses are affected, BMELLs are described most commonly in racehorses. Like in humans the bones of the distal limb are affected the most. BMELLs in the horse are described for the navicular bone, the middle phalanx and the metacarpal and metatarsal bone. The diagnosis is based on scintigraphical and MRI findings. In humans, the treatment depends on the severity of clinical, radiological and MR findings. Rest and reduced training is part of every treatment regime. Surgical treatment like bone drilling is described for severe cases. A correlation between BMELLs and osteoarthritis is discussed. This article describes a young dressage horse with a non-weight bearing lameness of sudden onset. Because clinical and radiological findings did not explain the lameness conclusively the horse underwent low field MR imaging (0,27T). On STIR images in sagittal and frontal planes a hyperintense focus with a hypointense rim was seen in the bone marrow in the dorsomedial part of the second phalanx. A corresponding hypointense focus was seen on T2*-weighted gradient echo sequences. On T2-weighted spin echo sequences the bone marrow appeared normal. The horse was treated with a Robert Jones bandage, NSAIDs for 14 days, disodium clodronate for ten days and box rest over a period of eight weeks. After that, the horse was walked at hand for four weeks. Fourteen weeks after the sudden onset of the lameness the horse was sound and started light dressage work.

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Section: Dieunclassified

Bone oedema like lesion of the second phalanx causing a non-weight bearing lameness in a 4 years old Trakehnen mare

Helweg¹,

Metzemacher²,

Schulze³

et al. 2014

PHK

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“…Calcium dobesilate (calcium 2,5-dihydroxybenzene sulphonate; CD; Figure 1a) is a synthetic venoactive drug used in veterinary medicine to treat equine navicular disease (Janssen et al, 2011). CD was investigated in a rabbit knee model of osteoarthritis (OA) where favourable effects on pressure dynamics in subchondral bone of osteoarthritic joints were found suggesting CD may be useful for medical management of OA by reducing bone marrow oedema (Miles et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Novel holistic pharmacokinetic model applied to plasma and urine concentrations of 2,5‐dihydroxybenzene sulphonate following administrations of calcium dobesilate and etamsylate to exercised horses

Paine

Harding²,

Waller³

et al. 2023

Vet Pharm & Therapeutics

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Calcium dobesilate (CD) is a synthetic venoactive drug used in veterinary medicine to treat equine navicular disease. Etamsylate is a haemostatic agent used in horses for the treatment of exercise‐induced pulmonary haemorrhage. Both etamsylate and CD dissociate in the circulatory system with 2,5‐HBSA as the active drug. The aim of the research was to be able to provide detection time (DT) advice from pharmacokinetic (PK) studies in Thoroughbred horses to better inform trainers, and their veterinary surgeons, prescribing these substances for treatment of Thoroughbred racehorses. Two (pilot study) and six (final study) horses were given 28 and 9 repeated dose of CD (3 mg/kg BID) respectively. Two horses were each given a single intravenous (IV) dose of etamsylate (10 mg/kg). Plasma and urine 2,5‐HBSA concentrations were measured by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The CD pilot study revealed that steady state could be reached with a few days and that 2,5‐HBSA in plasma and urine shows instability during storage at −20°C but appears stable at −80°C. A novel holistic non‐linear mixed‐effects three‐compartmental PK model was developed that described both plasma and urine concentrations of 2,5‐HBSA, from either CD or etamsylate administration. Typical values for 2,5‐HBSA clearance and bioavailability were 2.0 mL/min/kg and 28% respectively. Using the parameters obtained from this PK model, in conjunction with methodology developed by Toutain, afforded a possible screening limit (SL) that can regulate for a DT of 3 days in urine; however, a corresponding SL in plasma would be below current levels of detection. However, it is the responsibility of the individual racing authorities to apply their own risk management with regard to SLs and DTs.

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Role of increased tissue pressure in the pathophysiology of osteoarthritis

Fricker

Stuker²,

Schawalder

2012

Z. Rheumatol.

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Osteoarthritis is characterized by increased internal pressure in the subchondral bone tissue as well as in the joint capsule. In analogy to the pathophysiological mechanism of venous compartment syndrome it is demonstrated that the increased pressure is maintained by high protein edema and initiates a vicious circle. Drug-induced resorption of the osmotically active proteins leads to elimination of the high protein edema and is able to interrupt the pathophysiological process.

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Effects of Calcium dobesilate on horses with an increased signal intensity in the navicular bone in fat suppressed images on MRI: Pilot study

Cited by 8 publications

References 30 publications

Bone oedema like lesion of the second phalanx causing a non-weight bearing lameness in a 4 years old Trakehnen mare

Bone oedema like lesion of the second phalanx causing a non-weight bearing lameness in a 4 years old Trakehnen mare

Novel holistic pharmacokinetic model applied to plasma and urine concentrations of 2,5‐dihydroxybenzene sulphonate following administrations of calcium dobesilate and etamsylate to exercised horses

Role of increased tissue pressure in the pathophysiology of osteoarthritis

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