Effects of calorie restriction with n-3 long-chain polyunsaturated fatty acids on metabolic syndrome severity in obese subjects: A randomize-controlled trial

Lee, Hsiu Chuan; Cheng, Wen Yi; Hsu, Yi Hao; Su, Hsiu Yueh; Huang, Brian E T G; Lin, Yen‐Kuang; Chan, Wing P.; Su, Chien‐Tien; Huang, Shih‐Yi

doi:10.1016/j.jff.2015.01.040

Cited by 19 publications

(16 citation statements)

References 45 publications

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“…This pilot study was primarily conducted to analyse plasma protein profiles by using plasma samples of middle-aged women with MetS obtained from a cohort study [15,16]. A brief description of the selection criteria and study design follows.…”

Section: Methodsmentioning

confidence: 99%

Effects of Caloric Restriction with Protein Supplementation on Plasma Protein Profiles in Middle-Aged Women with Metabolic Syndrome—A Preliminary Open Study

Chang

Tung

Lin

et al. 2019

JCM

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Background: Clinical studies have demonstrated that higher protein intake based on caloric restriction (CR) alleviates metabolic abnormalities. However, no study has examined the effects of plasma protein profiles on caloric restriction with protein supplementation (CRPS) in metabolic syndrome (MetS). Therefore, using a proteomic perspective, this pilot study investigated whether CRPS ameliorated metabolic abnormalities associated with MetS in middle-aged women. Methods: Plasma samples of middle-aged women with MetS in CR (n = 7) and CRPS (n = 6) groups for a 12-week intervention were obtained and their protein profiles were analysed. Briefly, blood samples from qualified participants were drawn before and after the dietary treatment. Anthropometric, clinical, and biochemical variables were measured and correlated with plasma proteomics. Results: In results, we found that body mass index, total body fat, and fasting blood glucose decreased significantly after the interventions but were not different between the CR and CRPS groups. After liquid chromatography–tandem mass spectrometry analysis, the relative plasma levels of alpha-2-macroglobulin (A2M), C4b-binding protein alpha chain (C4BPA), complement C1r subcomponent-like protein (C1RL), complement component C6 (C6), complement component C8 gamma chain (C8G), and vitamin K-dependent protein S (PROS) were significantly different between the CRPS and CR groups. These proteins are involved in inflammation, the immune system, and coagulation responses. Moreover, blood low-density lipoprotein cholesterol levels were significantly and positively correlated with C6 plasma levels in both groups. Conclusions: These findings suggest that CRPS improves inflammatory responses in middle-aged women with MetS. Specific plasma protein expression (i.e., A2M, C4BPA, C1RL, C6, C8G, and PROS) associated with the complement system was highly correlated with fasting blood glucose (FBG), blood lipids (BLs), and body fat.

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Section: Methodsmentioning

confidence: 99%

Effects of Caloric Restriction with Protein Supplementation on Plasma Protein Profiles in Middle-Aged Women with Metabolic Syndrome—A Preliminary Open Study

Chang

Tung

Lin

et al. 2019

JCM

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“…We selected the study population from a previous study that contained 188 volunteers who met the diagnostic criteria for metabolic syndrome32. In the previous study, all participants were randomly assigned into one of four calorie-restriction diet groups to determine the effects of different diet regimens in patients with metabolic syndrome.…”

Section: Methodsmentioning

confidence: 99%

Reproducibility and Repeatability of Computer Tomography-based Measurement of Abdominal Subcutaneous and Visceral Adipose Tissues

Lee¹,

Hsiao²,

Yang

et al. 2017

Sci Rep

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Excessive accumulation of abdominal adipose tissue is a widely recognized as a major feature of obesity, and it can be quantified by dual-energy x-ray absorptiometry (DXA). However, in a phantom study, the inter- and intra-instrument reliability of DXA remains unpredictable. Thus, we attempted to determine the precision of estimates from computer tomography-based measurements and analysis with AZE Virtual Place software. To determine the inter-rater reproducibility and intra-rater repeatability of adipose tissue area estimates, we used the automatic boundary-tracing function of the AZE Virtual Place to generate cross-sectional areas of subcutaneous and visceral adipose tissues from the abdomen of reconstructed CT images. The variability of inter-rater and intra-rater estimates expressed as the coefficient of variation ranged from 0.47% to 1.43% for subcutaneous adipose tissue and 1.08% to 2.20% for visceral adipose tissue; the optimal coefficient of variation of the fat rate calculation ranged from 0.55% to 1.13%, respectively. There was high and significant correlation between adipose tissue areas as estimated in 40 obese subjects by two raters or repeatedly on 20 obese subjects by either rater. This indicates excellent reproducibility and repeatability via a computer tomography-based measurement of abdominal subcutaneous and visceral adipose tissues.

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“…Weight reduction data appear more encouraging when ω-3PUFA integration and calorie restriction are combined, but it is problematic to draw deductions due to the diversity of calorie limit programs in dissimilar trials. Combined ω-3PUFAs supplementation and calorie restriction compared to calorie restriction alone or replacement of saturated fatty acids determined a major amelioration in insulin resistance and reduction of TGs [ 68 , 69 ]. ω-3PUFAs could decrease body weight, thereby improving the metabolic profile through various mechanisms: alteration in adipokines release; modification of gene expression in adipose tissue; adipokine-mediated or adipokine-connected pathways; variation in carbohydrate metabolism; appetite suppression; rise in fat oxidation; intensification in energy expenditure (probably by thermogenesis); initiation of mechanisms related to muscle anabolism; and, lastly, epigenetic actions.…”

Section: The Antiobesity Effects Of ω-Pufasmentioning

confidence: 99%

ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer

2020

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Recently, nutraceutical bioactive compounds in foods have been discovered for their potential health benefits regarding the prevention of chronic disorders, such as cancer, and inflammatory, cardiovascular, and metabolic diseases. Dietary omega-3 polyunsaturated fatty acids (ω-3PUFAs), including alpha-linolenic acid, docosapentaenoic acid, and eicosapentaenoic acid, are mostly attractive. They are available for the customers worldwide from commonly used foods and/or as components of commercial food supplements. The anti-inflammatory and hypotriglyceridemic effects of these fatty acids are well known, whereas pro-inflammatory properties have been recognized in their dietary counterparts, the ω-6PUFAs. Both ω-3 and ω-6PUFAs contribute to the production of lipid mediators such as endocannabinoids that are notably involved in control of food intake, energy sensing, and food–related disorders. In this review, we present ω-3 and ω-6PUFAs and their derivatives, endocannabinoids; discuss the anti-obesity effects of ω-3PUFAs; their roles in inflammation and colorectal cancer development; and how their action can be co-preventative and co-therapeutic.

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Effects of calorie restriction with n-3 long-chain polyunsaturated fatty acids on metabolic syndrome severity in obese subjects: A randomize-controlled trial

Cited by 19 publications

References 45 publications

Effects of Caloric Restriction with Protein Supplementation on Plasma Protein Profiles in Middle-Aged Women with Metabolic Syndrome—A Preliminary Open Study

Effects of Caloric Restriction with Protein Supplementation on Plasma Protein Profiles in Middle-Aged Women with Metabolic Syndrome—A Preliminary Open Study

Reproducibility and Repeatability of Computer Tomography-based Measurement of Abdominal Subcutaneous and Visceral Adipose Tissues

ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer

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