Effects of carbamazepine and two of its metabolites on the non-biting midge Chironomus riparius in a sediment full life cycle toxicity test

Heye, Katharina; Becker, Dennis; Eversloh, Christian Lütke; Durmaz, Vedat; Ternes, Thomas A.; Oetken, Matthias; Oehlmann, Jörg

doi:10.1016/j.watres.2016.03.071

Cited by 54 publications

(18 citation statements)

References 52 publications

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“…Carbamazepine is an antiepileptic with a long half‐life, allowing its persistence and detection in aquatic ecosystems, and permitting its transfer along the food chain due to its ability to bio accumulate . Problems like mortality, emergence, and fertility of mosquitoes with semi‐ground larvae, oxidative stress in molluscs, and ecotoxicological problems in fish are also given in the literature. In 2007, the consumption of CBZ in Brazil reached 30.4 tons, thanks to the free distribution in the Pharmaceutical Assistance list of the Unified Health System, and the approval of its use by the National Health Surveillance Agency (ANVISA) .…”

Section: Introductionmentioning

confidence: 99%

Presence of Anthropogenic Markers in Water: A Case Study of the Guaporé River Watershed, Brazil

Bastos

Santos

Lima

et al. 2018

CLEAN Soil Air Water

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Southern Brazil is an agricultural region that is experiencing strong growth in both cereal and animal production. The intensification of agricultural practices, as well as the growing urbanization in this region, also generates strong anthropogenic pressures on the aquatic environment. In Brazil, the lack of sewage treatment and the wide use of waste (liquid or solid) for the fertilization of soils are likely to favor the spread of pharmaceuticals in the surrounding environment. Considering the benefits of the determination of anthropogenic markers in the environment, the study aimed to monitor the presence of carbamazepine (CBZ) and sucralose (SCR) in the Guaporé River, representative of a southern Brazilian rural watershed. Both carbamazepine and sucralose are measured in water by polar organic chemical integrative samplers (POCIS) (CBZ: lower than limit of detection (< LOD) to 746 μg g−1 and SCR:

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Section: Introductionmentioning

confidence: 99%

Presence of Anthropogenic Markers in Water: A Case Study of the Guaporé River Watershed, Brazil

Bastos

Santos

Lima

et al. 2018

CLEAN Soil Air Water

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“…The development time was also delayed as a result of DDX exposure (Figure ); for example, the times until 20% emergence of the midges were 31 and 45 d for the negative control and treatment L4, respectively. Delayed emergence would increase the chance for midge larvae being preyed on and impede the mating of the adults because of an extended time gap for the emergence of male and female midges, which in turn would induce undesirable outcomes on the population level (Forbes and Cold ; Heye et al ) and eventually affect the structure and function of the ecosystems (Sibley et al ).…”

Section: Resultsmentioning

confidence: 99%

Full–Life Cycle Toxicity Assessment of Sediment‐Bound DDT and Its Degradation Products on Chironomus dilutus

You

2019

Enviro Toxic and Chemistry

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Because of its hydrophobicity and persistence, dichlorodiphenyltrichloroethane (DDT) is ubiquitous in sediments and poses significant risk to benthic organisms. Therefore, it is imperative to evaluate the long‐term toxicity of DDT. However, limited information is available on its chronic toxicity to benthic invertebrates. Full–life cycle toxicity of sediment‐bound DDT to Chironomus dilutus was assessed. Median lethal concentrations (with 95% confidence limits) of DDT and its degradation products (DDX) to C. dilutus were 334 (165–568), 21.4 (11.2–34.3), and 7.50 (4.61–10.6) nmol/g organic carbon after 10‐, 20‐, and 63‐d exposure, respectively. In addition, median effect concentrations of DDX were 20.0 (15.0–25.3), 7.13 (4.10–10.5), and 8.92 (3.32–15.1) nmol/g organic carbon for growth, emergence, and reproduction, respectively. A toxicity spectrum was established to visually summarize chronic effects of DDX to midges. In addition, DDT degraded to dichlorodiphenyldichloroethane (DDD) and dichlorodiphenyldichloroethylene (DDE) during sediment aging, and their toxicity differed from that of the parent compound. Predicted toxic units of DDX in porewater were utilized to distinguish between toxicity from DDT and that of DDD and DDE. The results showed that DDD was the main contributor to the toxicity in C. dilutus. To improve the accuracy of sediment risk assessment of DDT, the composition of DDX should be considered. Environ Toxicol Chem 2019;38:2698–2707. © 2019 SETAC

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“…Challenges in the determination of ecotoxicity posed by the diversity of PhACs to be tested are further complicated by the large number of potentially exposed wildlife species and their specific target affinity and by the variety of toxicological endpoints that might be affected (Arnold et al ; Kostich and Länge ). Pharmaceutical metabolites and their potential ecotoxic effects are even less understood, and some studies have already shown metabolites’ toxicity to wildlife species to be often similar to or even worse than that of the parent compound (Heye et al ; Han and Lee ).…”

Section: Resultsmentioning

confidence: 99%

Modeling pharmaceutical emissions and their toxicity‐related effects in life cycle assessment (LCA): A review

Emara¹,

Lehmann²,

Siegert³

et al. 2018

Integr Envir Assess & Manag

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Over the last few decades, worldwide detection of active pharmaceutical ingredients (APIs) in aquatic environments and the associated toxicological effects on wildlife and human health have become a matter of public and scientific debate. While life cycle assessment (LCA) and life cycle impact assessment (LCIA) models are increasingly used to assess the potential eco-and human-toxicological effects of chemical emissions, few studies have looked into the issue of modeling pharmaceutical emissions specifically and their toxicity-related effects in an LCA context. This paper reviews the state of the art to inventory and characterize API emissions in LCA with the goal to identify relevant gaps and challenges. A search for 208 environmentally relevant APIs in 2 life cycle inventory (LCI) databases revealed a meager representation of this group of chemicals. Similarly, the LCIA model USEtox was found to include characterization factors (CFs) for less than 60 APIs. First approaches to model API emissions in LCA were identified on the basis of an examination of 40 LCA case studies in the pharmaceutical sector and in the field of wastewater treatment. Moreover, CFs for 79 additional APIs, expressing their ecotoxicity and/or human toxicity potential, were gathered from literature. An analysis of the variability of API-CFs in different LCIA models showed a variation of about 2-3 orders of magnitude. Based on the review results, 3 main gaps in the modeling and characterization of API emissions in an LCA context were identified: (1) incomplete modeling of API flows and API emissions along the life cycle of human pharmaceuticals, especially during their use and end-of-life phase, (2) limited API coverage in existing LCIA toxicity models, and (3) missing pharma-specific impact pathways (e.g., endocrine disruption and antibiotic resistance) in existing LCIA models. Recommendations to tackle these gaps are provided, and priority action steps are discussed. Integr Environ Assess Manag 2019;15:6-18. C 2018 SETAC

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Effects of carbamazepine and two of its metabolites on the non-biting midge Chironomus riparius in a sediment full life cycle toxicity test

Cited by 54 publications

References 52 publications

Presence of Anthropogenic Markers in Water: A Case Study of the Guaporé River Watershed, Brazil

Presence of Anthropogenic Markers in Water: A Case Study of the Guaporé River Watershed, Brazil

Full–Life Cycle Toxicity Assessment of Sediment‐Bound DDT and Its Degradation Products on Chironomus dilutus

Modeling pharmaceutical emissions and their toxicity‐related effects in life cycle assessment (LCA): A review

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