Effects of carbamazepine on the central nervous system of zebrafish at human therapeutic plasma levels

Yang, Weiwei; Bao, Yifan; Hao, Jiaoyang; Hu, Xialin; Xu, Ting; Yin, Daqiang

doi:10.1016/j.isci.2023.107688

Cited by 6 publications

(1 citation statement)

References 85 publications

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“…Approximately 28.6% of patients undergoing vigabatrin therapy exhibited visual field defects, as observed in a clinical setting . Carbamazepine is thought to impact the autonomic system by influencing the release and reuptake of acetylcholine . Therefore, it may be necessary to investigate potential negative effects of cardiac and respiratory disorders associated with seizures.…”

Section: Potential Side Effects Of Antiepileptic Drugsmentioning

confidence: 99%

Anticonvulsant Classes and Possible Mechanism of Actions

Abd-Allah,

El-Mohsen Anwar,

Mohammed

et al. 2023

ACS Chem. Neurosci.

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Epilepsy is considered one of the most common neurological disorders worldwide; it needs long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs, approximately 30% patients still suffer from drug-resistant epilepsy. Subsequently, searching for new anticonvulsants with lower toxicity and better efficacy is still in paramount demand. Using target-based studies in the discovery of novel antiepileptics is uncommon owing to the insufficient information on the molecular pathway of epilepsy and complex mode of action for most of known antiepileptic drugs. In this review, we investigated the properties of anticonvulsants, types of epileptic seizures, and mechanism of action for anticonvulsants.

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Section: Potential Side Effects Of Antiepileptic Drugsmentioning

confidence: 99%