1972
DOI: 10.1172/jci107041
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Effects of carbon tetrachloride on albumin synthesis

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1977
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Cited by 16 publications
(8 citation statements)
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“…It has also been shown that the decrease in liver TOD activity by CCl 4 intoxication is due to inhibition of liver protein synthesis by the toxicant [Maki et al, 1965;Sato and Maruyama, 1972]. In the present study, liver TDO activity was found to decrease with the progression of liver injury in rats given CCl 4 , although the serum level of albumin, the liver synthesis of which is known to be inhibited by the toxicant [Smuckler et al, 1961;Rothschild et al, 1972], decreased at a progressed stage of the liver injury. Post-administration of melatonin at pharmacological doses did not ameliorate either the decreases in liver TDO activity or serum albumin concentration found at a progressed stage of CCl 4 -induced acute liver injury.…”
Section: Discussionsupporting
confidence: 42%
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“…It has also been shown that the decrease in liver TOD activity by CCl 4 intoxication is due to inhibition of liver protein synthesis by the toxicant [Maki et al, 1965;Sato and Maruyama, 1972]. In the present study, liver TDO activity was found to decrease with the progression of liver injury in rats given CCl 4 , although the serum level of albumin, the liver synthesis of which is known to be inhibited by the toxicant [Smuckler et al, 1961;Rothschild et al, 1972], decreased at a progressed stage of the liver injury. Post-administration of melatonin at pharmacological doses did not ameliorate either the decreases in liver TDO activity or serum albumin concentration found at a progressed stage of CCl 4 -induced acute liver injury.…”
Section: Discussionsupporting
confidence: 42%
“…It is known that inhibition of protein synthesis occurs in the damaged liver of rats intoxicated once with CCl 4 [Smuckler et al, 1961;Faber et al, 1971;Rothschild et al, 1972;Poli et al, 1979]. It has been shown that liver TDO activity decreases with the development of liver injury in rats with a single CCl 4 intoxication [Maki et al, 1965;Magus and Fouts, 1968;Sato and Maruyama, 1972;Ohta et al, 1997b].…”
Section: Discussionmentioning
confidence: 99%
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“…Incubations were performed as noted in Fig. 3 (32), and carbon tetrachloride toxicity (33). Munro and coworkers (29,30) (32,33,36) observed that disaggregation of membrane-bound polysomes accompanies the depression of albumin synthesis.…”
Section: Resultsmentioning
confidence: 99%
“…It has been established both in vivo and in vitro that amino acid supply plays a unique role in regulating protein synthesis (28)(29)(30)(31)(32). This is particularly important in patients with uremia, because it has been concluded that derangements of hepatic protein synthesis in this syndrome are secondary to dietary protein deficiency (2).…”
Section: Discussionmentioning
confidence: 99%