Effects of carob-bean gum thickened formulas on infants’ reflux and tolerance indices

Abstract

Formula A (i.e., 0.33 g/100 mL of cold galactomannans) was effective in reducing certain pH-monitoring indices of uncomplicated GER, increased body weight and was well-tolerated by infants.

Nutritional Management of Gastroesophageal Reflux Among Infants in the Philippines: Insights From Real-World Evidence

“…intestinal disorders in early life [1]. The results of this observational survey are consistent with the findings of previous clinical studies on anti-regurgitation infant milk formulas containing the same thickening agents [18,19]. A randomized and partly double-blind clinical trial compared the same infant milk formula at 0.33 g/100 mL of cold CBG (formula A, Frisolac ® AR) with two other formulas at 0.45 g/100 mL of cold or hot CBG (formulas B and C).…”

“…A randomized and partly double-blind clinical trial compared the same infant milk formula at 0.33 g/100 mL of cold CBG (formula A, Frisolac ® AR) with two other formulas at 0.45 g/100 mL of cold or hot CBG (formulas B and C). Formula A was shown to be more effective in decreasing the occurrence of reflux episodes and improving clinical symptoms of GER (decreased night cough, crying and frequency of vomiting) after 2 weeks of intervention [18]. Also in a prospective, double-blind, randomized cross-over trial conducted in 115 formula-fed infants (2 weeks to 5 months old), a formula containing CBG at 0.33 g/L and hydrolyzed protein was more effective in reducing the number and volume of regurgitations compared to another formula containing a nonhydrolyzed protein and less CBG (0.33 g/L) [11].…”

CAROB (Ceratonia siliqua): HEALTH, MEDICINE, CHEMISTRY

“…102 Carob extracts are being studied in recent years for gastroprotective activities, and they were found highly active, so far. [155][156][157][158][159] Most studies were done in vivo after induction of gastric disorder in animals. These diorders were induced by various chemicals such as ethanol, hydrochloric acid, sodium chloride or dextran sulfate sodium.…”

“…159 A general structure of Carob galactomannan, polysaccharide composed of mannose in major chain, with galactose branching, is shown in figure 6 (short form). Carob phytoestrogens were found active in bone recovery.…”

Functional polysaccharides of carob fruit: a review

“…Miglena Georgieva et al [63] examined the effect of carob bean gum thickened-formulas on reflux and tolerance indices in infants with gastroesophageal reflux. In the study, fifty-six eligible infants (1–6 months old) were randomly allocated to receive a formula with either 0.33 g/100 mL (Formula A) or 0.45 g/100 mL (Formula B) of cold soluble carob bean gum galactomannans, respectively, or a formula with 0.45 g/100 mL of hot soluble carob bean gum galactomannans (Formula C) for 2 weeks.…”