Effects of carprofen on the integrity and barrier function of canine colonic mucosa

Abstract

Carprofen increased in vitro conductance and permeability to mannitol in canine colonic mucosa. Carprofen resulted in sloughing of cells and erosion of the colonic mucosa. These findings suggested that carprofen can compromise the integrity and barrier function of the colonic mucosa of dogs.

Carprofen for perioperative analgesia causes early anastomotic leakage in the rat ileum

“…Recent incidental reports suggest that carprofen administration to dogs alters functions of platelets, which are relevant to the repair sequence [17]. Also, carprofen has been shown to compromise the integrity and barrier function of the gastrointestinal mucosa in dogs [18]. The present data, which expand on a previous short communication [5] unequivocally demonstrate that carprofen can interfere significantly with anastomotic integrity in the rat small bowel.…”

In vitro effect of carprofen and meloxicam on the conductance and permeability to mannitol and the histologic appearance of the gastric mucosa of dogs

“…38 In that study, 38 mild epithelial sloughing was observed in 5 of 63 (7.9%) sections, moderate sloughing was observed in 17 of 63 (27.0%) sections, and severe sloughing was observed in 41 of 63 (65.0%) sections. 38 In that study, 38 mild epithelial sloughing was observed in 5 of 63 (7.9%) sections, moderate sloughing was observed in 17 of 63 (27.0%) sections, and severe sloughing was observed in 41 of 63 (65.0%) sections.…”

“…38 In that study, 38 mild epithelial sloughing was observed in 5 of 63 (7.9%) sections, moderate sloughing was observed in 17 of 63 (27.0%) sections, and severe sloughing was observed in 41 of 63 (65.0%) sections. 38 It was suggested that sloughing of cells and erosions likely contributed to an increase in electrical conductance and permeability recorded in carprofen-treated sections, compared with findings in untreated control samples. 38 Edema was not evident in 16 of 63 (25.4%) sections but was rated mild in 37 (58.7%) and moderate in 10 (15.9%) sections.…”

“…38 It was suggested that sloughing of cells and erosions likely contributed to an increase in electrical conductance and permeability recorded in carprofen-treated sections, compared with findings in untreated control samples. 38 In the study reported here, the epithelium was intact (without erosions) in most of the control sections (11/12 sections had mild or minimal sloughing) and edema was not detected in the control sections. Sloughing of cells from the surface epithelium, sloughing of cells within the mucosal glands, and edema in the colonic mucosa of rats after 60 minutes of immersion in an Ussing chamber was detected in another study.…”

“…No sloughing of cells was detected within the mucosal glands in 39 of 63 (61.9%) treated sections; sloughing to some extent was detected in 38.1% of sections. 38 In the present study, histologic examination of all sections of gastric mucosa at the end of the experiment was performed to verify viability and preservation of structural integrity in the control sections and to compare the histologic findings from the carprofen-and meloxicam-treated sections. 38 It was suggested that sloughing of cells and erosions likely contributed to an increase in electrical conductance and permeability recorded in carprofen-treated sections, compared with findings in untreated control samples.…”