Effects of carrageenan, PVP and tumour-bearer serum on immunity induced by excision or mitomycin C-treated tumour cells in mice

Kearney, R; Wu, Rong; Orr, F. W.

doi:10.1038/bjc.1979.116

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Similar observations have been made by others (Kearney et al, 1979) who demonstrated that carrageenan abolished the weak immunity for H1 tumor cells produced by previous excision of the tumor but had no effect on the stronger immunity induced by mitomycin-C-treated H1 cells. The tumor growth in carrageenan-treated tumor-excised mice was significantly greater than the growth in carrageenan-treated normal mice.…”

Section: Discussionsupporting

confidence: 88%

“…The tumor growth in carrageenan-treated tumor-excised mice was significantly greater than the growth in carrageenan-treated normal mice. They (Wu and Kearney, 1979) have also suggested that the stimulation of the growth of small tumor inocula by tumor fragments or non-viable cells was due to the reduced clearing of viable tumor cells by macrophages and that carrageenan stimulated tumor growth by removing macrophages. Thus it is possible that macrophages are required for non-specific tumor-cell clearance and that carrageenan simply reduces this function.…”

Section: Discussionmentioning

confidence: 99%

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Non‐specific cytotoxic cells generated in vitro in response to a weakly immunogenic murine adenocarcinoma. In vivo correlations

Pope¹,

Justice²,

Sarma³

et al. 1981

Intl Journal of Cancer

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Tumor 85 adenocarcinoma cells, which are very weakly immunogenic for C3H/HeN (C3H) mice, provide a model tumor system for studying the parameters of induction of a cell-mediated immune response which does not appear to be a traditional cytotoxic T-cell or NK-cell response. Mice pre-immunized with irradiated tumor 85 cells are protected about 50% of the time from a challenge of viable tumor 85 cells although it is never possible to protect 100% of the immunized mice. Optimal protection is observed in mice immunized with 10(6) irradiated tumor 85 cells 14 days prior to challenge. Protection is also observed if mice are immunized with Protection is also observed if mice are immunized with 3H or C3HfeB/HeN (C3Hf) tumors originally induced by the same carcinogen as that used to induce tumor 85. The injection of carrageenan 1 h before challenge completely reverses the protection observed in immunized mice and and tumors grow faster in carrageenan-treated immunized mice than in normal mice. Two populations of cells obtained from cultures of spleen cells stimulated by tumor 85 cells appear to prevent tumor growth in vivo. One population, which is cytotoxic for tumor 85 cells in vitro, is nylon-wool-adherent and expresses Thy 1.2. The second population, which is not observed to be cytotoxic in a 51Cr release assay, is phagocytic.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Non‐specific cytotoxic cells generated in vitro in response to a weakly immunogenic murine adenocarcinoma. In vivo correlations

Pope¹,

Justice²,

Sarma³

et al. 1981

Intl Journal of Cancer

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Modulation of anti‐tumour immunity induced by syngeneic mitomycin C‐treated murine tumour cells

Kearney

Harrop

1984

Intl Journal of Cancer

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Experiments were performed to examine the kinetics of delayed-type hypersensitivity (DTH) to mitomycin-C-treated syngeneic murine fibrosarcomas inoculated into the footpads of mice. Evidence is presented to show that a "strongly" antigenic tumour, designated H7, elicits consecutive waves of footpad swelling in both primary and secondary responses. Periods of anti-tumour resistance coincided with the expression of each successive wave of footpad swelling in normal and immune mice. The down-regulation of the response, between the successive peaks of footpad swelling, was accompanied by active tumour growth. In contrast, the non-cross-reacting "weakly" antigenic tumour, designated H1, induced footpad swelling which was expressed only once after either primary or secondary sensitization. Unlike that induced by the "strongly" antigenic H7 tumour, the anti-tumour immunity to the H1 tumour was not sustained beyond its initial specific phase. Consequently, H1 tumour cells which survived the initial phase of anti-tumour immunity appeared to encounter no further resistance. Thus the distinctive feature of the "weakly" antigenic H1 tumour was its inability to sustain consecutive waves of tumour resistance as exhibited by the "strongly" antigenic H7 tumour. It is proposed that "weakly" and "strongly" antigenic tumours are distinguished by their different abilities to down-regulate the anti-tumour immune response. The "weakly" antigenic tumour induces specific immunity which is rapidly down-regulated while that induced by the "strongly" antigenic tumour is sustained by successive waves of anti-tumour activity of diminishing intensity. Suppression of some but not all waves of footpad swelling occurred in mice with growing H7 tumours.

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Host modification on the skin allograft assay

Kemeny

Sugarbaker

1982

Journal of Surgical Research

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Effects of carrageenan, PVP and tumour-bearer serum on immunity induced by excision or mitomycin C-treated tumour cells in mice

Cited by 4 publications

References 20 publications

Non‐specific cytotoxic cells generated in vitro in response to a weakly immunogenic murine adenocarcinoma. In vivo correlations

Non‐specific cytotoxic cells generated in vitro in response to a weakly immunogenic murine adenocarcinoma. In vivo correlations

Modulation of anti‐tumour immunity induced by syngeneic mitomycin C‐treated murine tumour cells

Host modification on the skin allograft assay

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