Effects of carvedilol on oxidative stress in polymorphonuclear and mononuclear cells in patients with essential hypertension

Yasunari, Kenichi; Maeda, Kensaku; Nakamura, Munehiro; Watanabe, Takanori; Yoshikawa, Junichi; Asada, Akira

doi:10.1016/j.amjmed.2003.10.029

Cited by 60 publications

(42 citation statements)

References 23 publications

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“…Details show in our previous publication. 6,[18][19][20] Carotid arteries were evaluated using a Nemiopremium compact (TOSHIBA Co., Tokyo, Japan) and a 7.5 MHz probe. After the subject had rested for at least 10 min in the supine position with the neck in slight hyperextension, we examined an optimal visualization of the common carotid artery (CCA), carotid bulb, and extracranial internal and external carotid arteries bilaterally.…”

Section: Methodsmentioning

confidence: 99%

Carotid artery intima-media thickness and reactive oxygen species formation by monocytes in hypertensive patients

et al. 2006

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Carotid artery intima-media thickness (IMT) is a widely accepted index for assessing atherosclerosis, and is known to be a risk indicator for cardiovascular and cerebrovascular events. Oxidative stress and inflammation are also known to play critical roles in the pathogenesis of vascular events. We studied the association between IMT and inflammatory markers, such as oxidative stress in polymorphonuclear leukocytes (PMNs) and mononuclear cells (MNCs) in 156 patients with essential hypertension. Reactive oxygen species (ROS) formation by PMNs and MNCs was measured by gated flow cytometry. CRP and traditional risk factors, such as age, gender, body mass index, hemoglobin A 1c , and total cholesterol were also measured. The subjects were divided into a plaque group (max-IMTX1.1 mm, n ¼ 40), and a nonplaque group (max-IMTo1.1 mm, n ¼ 116). ROS formation by MNCs was significantly increased in the plaque group when compared with the nonplaque group (Po0.0001). Multiple regression analysis revealed a significant correlation between IMT and ROS formation by MNCs (r ¼ 0.407, Po0.0001), or CRP (r ¼ 0.216, P ¼ 0.0029) or hemoglobinA1c (r ¼ 0.158, P ¼ 0.0270) or age (r ¼ 0.157, P ¼ 0.0447). No significant correlation was observed between IMT and ROS formation by PMNs. These results suggest that carotid artery IMT may be affected by increased ROS formation by MNCs, and that increased ROS formation by MNCs may be related to the development of atherosclerosis. We propose that ROS formation by MNCs is a marker for prediction of carotid atherosclerosis.

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Section: Methodsmentioning

confidence: 99%

Carotid artery intima-media thickness and reactive oxygen species formation by monocytes in hypertensive patients

et al. 2006

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“…After 3 months of nonpharmacologic, β-blocker, or angiotensin receptor blocker treatment, oxidized/reduced glutathione ratio and malondialdehyde were significantly reduced, and this was further reduced after 12 months in a subgroup of patients. Yasunari et al [20] demonstrated that both carvedilol and propranolol reduced oxidative stress in patients with essential hypertension, although the effect was greater with carvedilol. Napoli et al [21] demonstrated that treatment with the sulfhydryl angiotensin-converting enzyme inhibitor zofenopril induced sustained reduction of systemic oxidative stress and improved the NO pathway in patients with essential hypertension.…”

Section: Oxidative Stressmentioning

confidence: 99%

Endothelial dysfunction: its role in hypertensive coronary disease

Bolad

Delafontaine

2005

Current Opinion in Cardiology

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Purpose of review-Coronary artery disease is the major cause of death worldwide. Hypertension is a major risk factor for developing coronary disease. It is now recognized that endothelial dysfunction is an early marker of coronary artery disease before structural changes to the vessel wall are apparent on angiography or intravascular ultrasound and that it has a prognostic value in predicting cardiovascular events in hypertensive patients. This review addresses recent developments in hypertension-induced endothelial dysfunction.Recent findings-Hyperaldosteronism causes endothelial dysfunction independent of high blood pressure. Exaggerated exercise blood pressure response has been related to endothelial dysfunction. Cyclosporin-A-induced endothelial dysfunction is related to reduced cholesterol content in caveolae. Chronic kidney disease induces changes in caveoli-1 and thus contributes to the reduced nitric oxide bioavailability, and causes oxidative stress independent of the high blood pressure. Asymmetric dimethylarginine plays a role in endothelial dysfunction in hypertensive patients independent of insulin resistance. 20-Hydroxyeicosatetraenoic acid is an independent predictor of hypertension in postmenopausal women. Endothelial dysfunction precedes and predicts the development of hypertension in postmenopausal women. Oral treatment with Larginine improves endothelial dysfunction in hypertensives and lowers the blood pressure.Summary-The pathophysiology of endothelial dysfunction in hypertension is multifactorial. Recent findings have contributed to our understanding of mechanisms of endothelial dysfunction and support a role for early intervention to prevent irreversible vascular and organ damage.

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“…Су-ществуют данные о позитивном воздействии препаратов этой группы на индекс аугментации. Установлено, что вазодилатирующие БАБ (небиволол и карведилол), по-вышая синтез оксида азота, вызывают расширение артерий и снижение ОПСС, что позволяет нивелировать прирост отражённой волны [10,11].…”

Section: Discussionunclassified