Effects of Castration, Estrogen, and Androgen Administration

Lee, Chung; Jesik, C

doi:10.1007/978-1-4612-5476-8_20

Cited by 10 publications

(2 citation statements)

References 57 publications

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“…The reagents used for those assays were anti-17␤-estradiol antiserum (Biogenesis, Sandown, NH), which was obtained by immunization of rabbits with 17␤-estradiol 6-(O-carboxymethyl)-oxime-bovine serum albumin and which shows an identical cross-reactivity to estrone, [2,4,6, ; 86.5 Ci/mmol; NEN) and 5␣-dihydrotestosterone (DHT; Sigma Chemical Co.). For the estrogen binding study, we used 17␤-estradiol (E 2 ; Nacalai Tesque Co.), 17␤-estradiol 3-sulfate (E 2 3-S), ␤-estradiol 3-sulfate-17-glucuronide (E 2 3-S-17-G), ␤-estradiol 17-(␤-D-glucuronide) (E 2 17-G), estrone 3-sulfate (E 1 3-S), and estriol 3-sulfate (E 3 3-S) ergosterol (ERG) (all products of Sigma Chemical Co.).…”

Section: Reagentsmentioning

confidence: 99%

“…For this reason, a decrease in the concentration of androgens in the blood due, e.g., to castration, leads to loss of the prostate epithelial cells' ability to differentiate and the atrophy of cells [5,6]. Androgens are also known to play a key role in the onset and progression of BPH, and for this reason antiandrogens and 5 ␣-reductase inhibitors are widely employed in the treat-ment of this disease.…”

Section: Introductionmentioning

confidence: 98%

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Effects of Mepartricin, a polyene macrolide agent, on fecal excretion and serum concentration of estrogen and number of prostatic estrogen receptors in immature rats

Shakutou¹,

Bandoh²,

Yoshinaka³

et al. 1999

Prostate

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Section: Reagentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Effects of Mepartricin, a polyene macrolide agent, on fecal excretion and serum concentration of estrogen and number of prostatic estrogen receptors in immature rats

Shakutou¹,

Bandoh²,

Yoshinaka³

et al. 1999

Prostate

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Development of a model for the induction of estrogen‐related prostatic hyperplasia in the dog and its response to the aromatase inhibitor 4‐hydroxy‐4‐androstene‐3,17‐dione: Preliminary results

Habenicht¹,

Schwarz²,

Schweikert³

et al. 1986

The Prostate

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Although the presence of the testes is an absolutely necessary prerequisite for benign prostatic hyperplasia (BPH) to occur, the role of androgens in the cause of BPH is still controversial. There are increasing signs for a decisive role of estrogens in that connection. We treated castrated beagle dogs of known age with androstenedione (an androgen that can be aromatized) and with the aromatase inhibitor 4-hydroxyandrostendione. Six or 9 months of treatment with androstenedione resulted in a BPH characterized by typical androgenic effects--ie, hyperplasia and hypertrophy of the epithelium--and by typical estrogenic effects--, stimulation of the stroma, especially of the smooth muscles, and cystic enlargement of the tubules. These estrogen-related effects could be clearly antagonized by the simultaneous treatment with the aromatase inhibitor 4-hydroxyandrostenedione. The hyperplastic effects on the epithelium were also partly antagonized by the aromatase inhibitor. Our preliminary results further strengthen the effectiveness of aromatase inhibitors as an alternative treatment of human BPH, which is thought to be predominantly a stromal disease.

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Synergic inhibitory effects of the aromatase inhibitor 1‐methyl‐androsta‐1, 4‐diene‐3, 17‐dione and the antiandrogen cyproterone acetate on androstenedione‐ induced hyperplastic effects in the prostates of castrated dogs

Habenicht¹,

Etreby²

1987

The Prostate

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We examined whether the induction of estrogen-related hyperplastic changes in the prostate (ie, activation and stimulation of the stroma, especially of the smooth muscle) of castrated beagle dogs was reproducible. The effectiveness of the aromatase inhibitor 1-methyl-androsta-1, 4-diene-3, 17-dione (1-Methyl-ADD) in antagonizing such estrogen-related alterations was investigated in comparison with a combined treatment of 1-Methyl-ADD and the antiandrogen CPA. These studies have demonstrated the suitability of the androstenedione model for testing the efficacy of aromatase inhibitors. In addition, it has been demonstrated that an aromatase inhibitor in combination with an antiandrogen can synergically inhibit the glandular and stromal components of the prostate.

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Effects of Castration, Estrogen, and Androgen Administration

Cited by 10 publications

References 57 publications

Effects of Mepartricin, a polyene macrolide agent, on fecal excretion and serum concentration of estrogen and number of prostatic estrogen receptors in immature rats

Effects of Mepartricin, a polyene macrolide agent, on fecal excretion and serum concentration of estrogen and number of prostatic estrogen receptors in immature rats

Development of a model for the induction of estrogen‐related prostatic hyperplasia in the dog and its response to the aromatase inhibitor 4‐hydroxy‐4‐androstene‐3,17‐dione: Preliminary results

Synergic inhibitory effects of the aromatase inhibitor 1‐methyl‐androsta‐1, 4‐diene‐3, 17‐dione and the antiandrogen cyproterone acetate on androstenedione‐ induced hyperplastic effects in the prostates of castrated dogs

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