Effects of Catalpol on Alzheimer’s Disease and Its Mechanisms

Abstract

Alzheimer’s disease (AD) is a degenerative disease of the central nervous system characterized by memory loss and cognitive dysfunction. With the increasing aging of the population, the incidence of AD and the number of patients are also increasing year by year, causing more and more heavy burdens to the family and society. Catalpol, an iridoid glycoside compound, is one of the main active components of Rehmannia glutinosa. At present, a large number of experimental studies in vivo and in vitro have confirmed that catalpol has antioxidant, anti-inflammatory, antiapoptotic, and other neuroprotective effects, and it plays a significant role in the prevention and treatment of AD, with very small side effects and high safety. Therefore, it may be an ideal drug for the treatment of AD. Based on this, the role and mechanism of catalpol in AD will be comprehensively reviewed in the following.

Immune-boosting effect of Yookgong-dan against cyclophosphamide-induced immunosuppression in mice

“…A series of studies have already demonstrated the immunopotentiating and modulating effects of catalpol against Rehmannia glutinosa (Gaertn.) Steud [ [49] , [50] , [51] ], α-pinene against Angelica gigas Nakai [ [52] , [53] , [54] , [55] ] and loganin and moroniside for Cornus officinalis Siebold & Zucc [ 56 , 57 ].…”

Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

“…It has wide pharmacological activities on the blood, immune, endocrine, cardiovascular, and nervous systems [31]. Catalpol, an iridoid glycoside compound in Rehmannia root, has antioxidant, antiinflammatory, antiapoptotic, and neuroprotective effects [32].…”

The Mechanism of Catalpol to Improve Oxidative Damage of Dermal Fibroblasts Based on Nrf2/HO-1 Signaling Pathway

“… 8 Recent studies have proven that it has multiple pharmacological effects such as antioxidant, anti-inflammatory, anti-tumor, neuroprotective, hypoglycemic, etc. 9 , 10 In recent years, many studies have focused on the mechanism of catalpol’s hypoglycemic and anti-tumor actions in vivo and in vitro. 9 , 11 , 12 However, the intervention’s effect on dermal fibroblasts’ function is still unclear.…”