Effects of catechin on a rodent model of autism spectrum disorder: implications for the role of nitric oxide in neuroinflammatory pathway

Mehta, Rishab; Bhandari, Ranjana; Kuhad, Anurag

doi:10.1007/s00213-021-05941-5

Cited by 17 publications

(8 citation statements)

References 79 publications

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“…In BTBR mice, the 5-AIQ treatment significantly prevented self-grooming and marble burying behaviors and ameliorated neuroimmune dysfunctions (Ahmad et al, 2020). Similarly, the benefits to RRBs were reported in the study of the administration of catechin hydrate and pioglitazone in VPA-induced rats (Mirza and Sharma, 2019a;Mehta et al, 2021) and sulforaphane in BTBR mice (Nadeem et al, 2019b). They corrected immune dysfunction and oxidant-antioxidant imbalance in periphery and brain in mice.…”

Section: Preclinical Pharmacological Studiesmentioning

confidence: 67%

Repetitive Restricted Behaviors in Autism Spectrum Disorder: From Mechanism to Development of Therapeutics

2022

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Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social communication, social interaction, and repetitive restricted behaviors (RRBs). It is usually detected in early childhood. RRBs are behavioral patterns characterized by repetition, inflexibility, invariance, inappropriateness, and frequent lack of obvious function or specific purpose. To date, the classification of RRBs is contentious. Understanding the potential mechanisms of RRBs in children with ASD, such as neural connectivity disorders and abnormal immune functions, will contribute to finding new therapeutic targets. Although behavioral intervention remains the most effective and safe strategy for RRBs treatment, some promising drugs and new treatment options (e.g., supplementary and cell therapy) have shown positive effects on RRBs in recent studies. In this review, we summarize the latest advances of RRBs from mechanistic to therapeutic approaches and propose potential future directions in research on RRBs.

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Section: Preclinical Pharmacological Studiesmentioning

confidence: 67%

Repetitive Restricted Behaviors in Autism Spectrum Disorder: From Mechanism to Development of Therapeutics

2022

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“…are crucial to exclude any factors that may confound our positive results in regard to the behavioral improvements provided by APG and/or ARP, such as changes in locomotor activity. Interestingly, our results are in agreement with numerous previous preclinical studies carried out in experimental rodents and in which different types of compounds belonging to the flavonoids, e.g., baicalin, genistein, naringenin, quercetin, hesperetin, catechin, anthrocyanin, epigallocatechin-3-gallate, and luteolin, were able to ameliorate several behavioral ASD-like deficits and mitigate the disturbed levels of oxidative stress in the brains of tested animals, e.g., CAT, MDA, SOD, and GSH [ 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. Also, our observations agree with the results obtained for APG in a pervious study in which APG provided neuroprotective, anti-amyloidogenic, and neurotrophic effects in an Alzheimer’s disease mouse model, signifying the capability of APG to improve the cognitive functions of tested animals [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Apigenin Alleviates Autistic-like Stereotyped Repetitive Behaviors and Mitigates Brain Oxidative Stress in Mice

Jayaprakash,

Isaev,

Yang

et al. 2024

Pharmaceuticals

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Studying the involvement of nicotinic acetylcholine receptors (nAChRs), specifically α7-nAChRs, in neuropsychiatric brain disorders such as autism spectrum disorder (ASD) has gained a growing interest. The flavonoid apigenin (APG) has been confirmed in its pharmacological action as a positive allosteric modulator of α7-nAChRs. However, there is no research describing the pharmacological potential of APG in ASD. The aim of this study was to evaluate the effects of the subchronic systemic treatment of APG (10–30 mg/kg) on ASD-like repetitive and compulsive-like behaviors and oxidative stress status in the hippocampus and cerebellum in BTBR mice, utilizing the reference drug aripiprazole (ARP, 1 mg/kg, i.p.). BTBR mice pretreated with APG (20 mg/kg) or ARP (1 mg/g, i.p.) displayed significant improvements in the marble-burying test (MBT), cotton-shredding test (CST), and self-grooming test (SGT) (all p < 0.05). However, a lower dose of APG (10 mg/kg, i.p.) failed to modulate behaviors in the MBT or SGT, but significantly attenuated the increased shredding behaviors in the CST of tested mice. Moreover, APG (10–30 mg/kg, i.p.) and ARP (1 mg/kg) moderated the disturbed levels of oxidative stress by mitigating the levels of catalase (CAT) and superoxide dismutase (SOD) in the hippocampus and cerebellum of treated BTBR mice. In patch clamp studies in hippocampal slices, the potency of choline (a selective agonist of α7-nAChRs) in activating fast inward currents was significantly potentiated following incubation with APG. Moreover, APG markedly potentiated the choline-induced enhancement of spontaneous inhibitory postsynaptic currents. The observed results propose the potential therapeutic use of APG in the management of ASD. However, further preclinical investigations in additional models and different rodent species are still needed to confirm the potential relevance of the therapeutic use of APG in ASD.

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“…One study reported that catechin inhibited the gene expression of pro-inflammatory cytokines IL-1β and IL-6, and enhanced the gene expression of anti-inflammatory cytokines IL-4 and IL-10 [91]. At a behavioral level, catechin (25, 50, and 100 mg/kg administered orally for 11 to 25 days) was associated with significant improvement in behavioral manifestations of sociability, stereotypy, anxiety, depression, novelty, repetitive, and perseverative behaviors in rodents [92]. Another study showed that β-catechin increased life-span in a senescence accelerated mouse model of aging [93].…”

Section: The Role Of Immunomodulatory Mechanismsmentioning

confidence: 92%

Natural Polyphenols—Resveratrol, Quercetin, Magnolol, and β-Catechin—Block Certain Aspects of Heroin Addiction and Modulate Striatal IL-6 and TNF-α

ElShebiney

Elgohary

El-Shamarka

et al. 2023

Toxics

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We have examined the effects of four different polyphenols in attenuating heroin addiction using a conditioned place preference (CPP) paradigm. Adult male Sprague Dawley rats received heroin (alternating with saline) in escalating doses starting from 10 mg/kg, i.p. up to 80 mg/kg/d for 14 consecutive days. The rats were treated with distilled water (1 mL), quercetin (50 mg/kg/d), β-catechin (100 mg/kg/d), resveratrol (30 mg/kg/d), or magnolol (50 mg/kg/d) through oral gavage for 7 consecutive days, 30 min before heroin administration, starting on day 8. Heroin withdrawal manifestations were assessed 24 h post last heroin administration following the administration of naloxone (1 mg/kg i.p). Heroin CPP reinstatement was tested following a single dose of heroin (10 mg/kg i.p.) administration. Striatal interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) were quantified (ELISA) after naloxone-precipitated heroin withdrawal. Compared to the vehicle, the heroin-administered rats spent significantly more time in the heroin-paired chamber (p < 0.0001). Concomitant administration of resveratrol and quercetin prevented the acquisition of heroin CPP, while resveratrol, quercetin, and magnolol blocked heroin-triggered reinstatement. Magnolol, quercetin, and β-catechin blocked naloxone-precipitated heroin withdrawal and increased striatal IL-6 concentration (p < 0.01). Resveratrol administration was associated with significantly higher withdrawal scores compared to those of the control animals (p < 0.0001). The results of this study show that different polyphenols target specific behavioral domains of heroin addiction in a CPP model and modulate the increase in striatal inflammatory cytokines TNF-α and IL-6 observed during naloxone-precipitated heroin withdrawal. Further research is needed to study the clinical utility of polyphenols and to investigate the intriguing finding that resveratrol enhances, rather than attenuates naloxone-precipitated heroin withdrawal.

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Effects of catechin on a rodent model of autism spectrum disorder: implications for the role of nitric oxide in neuroinflammatory pathway

Cited by 17 publications

References 79 publications

Repetitive Restricted Behaviors in Autism Spectrum Disorder: From Mechanism to Development of Therapeutics

Repetitive Restricted Behaviors in Autism Spectrum Disorder: From Mechanism to Development of Therapeutics

Apigenin Alleviates Autistic-like Stereotyped Repetitive Behaviors and Mitigates Brain Oxidative Stress in Mice

Natural Polyphenols—Resveratrol, Quercetin, Magnolol, and β-Catechin—Block Certain Aspects of Heroin Addiction and Modulate Striatal IL-6 and TNF-α

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