Effects of caudate nuclei or frontal cortex ablations in cats. II. Sleep-wakefulness, EEG, and motor activity

Villablanca, Jaime R.; Marcus, Robert J.; Olmstead, Charles E.

doi:10.1016/0014-4886(76)90279-x

Cited by 85 publications

(21 citation statements)

References 37 publications

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“…1). These animals, as well as kittens with frontal pole removal (afrontals) and sham midline penetration lesions, were studied through juvenile age or adulthood.Similar qualitative deficits and behavioral pecularities to those seen in adult acaudate cats [1,[3][4][5] were observed. Generally, the changes were less marked and more transient.…”

supporting

confidence: 66%

“…We postulate that the caudate participates in (a) processing of sensory inputs in an apparently inhibitory manner such that the imbalance created by its absence pro duces a hyperreactive, stimulus-bound, sticky and perseverative animal; several electrophysiological reports support this hypotheses [2]; (b) initia tion of complex motor performances such that its absence produces the akinetic type manifestations seen [1,2; Buclnvald et al, this symposium]: (c) control of arousal and general motor activity CNS processes also in an inhibitory manner such that its absence produces motor hyperactivity and hyposomnia [3], and (d) control of 'affective' type behaviors such that its absence determines the stereotyped friendliness and docility of the ap proaching syndrome.…”

mentioning

confidence: 99%

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Effects of Caudate Nuclei Removal in Kittens

Villablanca¹,

Olmstead²

1979

Stereotact Funct Neurosurg

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supporting

confidence: 66%

mentioning

confidence: 99%

Effects of Caudate Nuclei Removal in Kittens

Villablanca¹,

Olmstead²

1979

Stereotact Funct Neurosurg

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“…Concurrently, the same region and also the adjacent olfactory tubercle reportedly contain neurons that discharge more frequently during wakefulness than during non-rapid-eye-movement sleep (23,25). In addition, the septum and orbitofrontal cortex, which were also implicated in the sleep-wake regulating system (26,27), are located in the surrounding region. Furthermore, cholinergic and GABAergic (GABA = y-taminobutyric acid) neurons are spread widely along the ventral surface in this vicinity without being organized into a compact nucleus (28).…”

Section: Discussionmentioning

confidence: 99%

Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain.

Matsumura¹,

Nakajima²,

Osaka³

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

128

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The site of action for the sleep-promoting effect of prostaglandin (PG) D2 was extensively examined in the brain of adult male rats (n = 231). PGD2 was administered at 100 pmol/0.2 pI per min for 6 hr (2300-0500 hr) through chronically implanted microdialysis probes or infusion cannulae. Among the administrations of PGD2 by dialysis probes (n = 176), only those (n = 8) to a ventro-rostral part of the basal forebrain by the probes implanted on the midline consistently increased slow-wave sleep (SWS), by 51 ± 6 min (mean ± SEM) above the baseline value (111 ± 11 min). Since this area is separated by a cleft into right and left regions, the results were interpreted to mean that, through this cleft, PGD2 diffused in the subarachnoid space over the adjacent ventral surface, where it had the effect ofpromoting sleep. When PGD2 was directly infused into the subarachnoid space (n = 55), extraordinary increases exceeding 90 min were consistently attained for the SWS at sites located between 0.5 and 2 mm rostral to the bregma and between 0 and 1.2 mm lateral to the midline defined according to the stereotaxic coordinates adopted from the brain atlas of Paxinos and Watson [Paxinos, G. & Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates (Academic, San Diego)]. Thus, we demarcated a "PGD2-sensitive, sleep-promoting zone" within this region in the ventral surface of the rostral basal forebrain. During the bilateral infusion of PGD2 into the subarachnoid space of this zone, the hourly mean SWS level of the nocturnal animals (n = 6) in the night reached the maximum at the second hour of the infusion period; this maximum hourly SWS level, corresponding to the daytime level of the same animals, lasted until the end of PGD2 infusion.Prostaglandin D2 (PGD2) has been postulated as one of the endogenous sleep-promoting substances in rats and other mammals including humans (1). PGD2 has been implicated in the physiological regulation of sleep by the fact that sleep in rats was markedly suppressed by intracerebroventricular (2) or intravenous (3) administration of inorganic selenium compounds, which are inhibitors of PGD synthase (EC 5.3.99.2), the enzyme responsible for the synthesis of PGD2 in the rat brain (4).The preoptic area (POA) has long been proposed as a sleep center since the experimental study by Nauta in 1946 (5). The site of action for the sleep-promoting effect of PGD2 has been postulated to be located in or near the POA since an increase in the amount of sleep was first demonstrated with PGD2 in 1982 by a microinjection study (6). Subsequent studies in monkeys (7) and rats (8) also supported the assumption that the site of action is located in a rostral and ventral region, adjacent to the third cerebral ventricle; however, the exact site of action has not yet been clearly defined.In this paper, the site most effective in promoting sleep with PGD2 administration was extensively studied by use of the microdialysis technique and the continuous infusion method. The results clearly define the site of action ...

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“…Furthermore, basal ganglia might also regulate the activity of the reticular core via their projections to the pontine and mesencephalic reticular formation. In favour of the role of basal ganglia in SWS regulation, it should be remembered that the mechanical removal of the striatum (caudate nucleus) causes long-lasting insomnia in cats (Villablanca et al 1976). In contrast, low-frequency electrical stimulation of the caudate nucleus induces EEG synchronization and behavioural inhibition (Siegel and Wang 1974).…”

Section: Slow-wave Sleepmentioning

confidence: 99%

Functional neuroimaging of normal human sleep by positron emission tomography

Maquet

2000

Journal of Sleep Research

566

312

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Functional neuroimaging using positron emission tomography has recently yielded original data on the functional neuroanatomy of human sleep. This paper attempts to describe the possibilities and limitations of the technique and clarify its usefulness in sleep research. A short overview of the methods of acquisition and statistical analysis (statistical parametric mapping, SPM) is presented before the results of PET sleep studies are reviewed. The discussion attempts to integrate the functional neuroimaging data into the body of knowledge already acquired on sleep in animals and humans using various other techniques (intracellular recordings, in situ neurophysiology, lesional and pharmacological trials, scalp EEG recordings, behavioural or psychological description). The published PET data describe a very reproducible functional neuroanatomy in sleep. The core characteristics of this ‘canonical’ sleep may be summarized as follows. In slow‐wave sleep, most deactivated areas are located in the dorsal pons and mesencephalon, cerebellum, thalami, basal ganglia, basal forebrain/hypothalamus, prefrontal cortex, anterior cingulate cortex, precuneus and in the mesial aspect of the temporal lobe. During rapid‐eye movement sleep, significant activations were found in the pontine tegmentum, thalamic nuclei, limbic areas (amygdaloid complexes, hippocampal formation, anterior cingulate cortex) and in the posterior cortices (temporo‐occipital areas). In contrast, the dorso‐lateral prefrontal cortex, parietal cortex, as well as the posterior cingulate cortex and precuneus, were the least active brain regions. These preliminary studies open up a whole field in sleep research. More detailed explorations of sleep in humans are now accessible to experimental challenges using PET and other neuroimaging techniques. These new methods will contribute to a better understanding of sleep functions.

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Effects of caudate nuclei or frontal cortex ablations in cats. II. Sleep-wakefulness, EEG, and motor activity

Cited by 85 publications

References 37 publications

Effects of Caudate Nuclei Removal in Kittens

Effects of Caudate Nuclei Removal in Kittens

Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain.

Functional neuroimaging of normal human sleep by positron emission tomography

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