Effects of cefuroxime axetil combined with Xingpi Yanger granules on the serum gastrin, motilin, and somatostatin levels in children with upper respiratory tract infection accompanied by diarrhea: results of a randomized trial

Abstract

Background: The purpose of the study was to investigate the effects of cefuroxime axetil combined with Xingpi Yanger granules on the treatment of upper respiratory tract infection accompanied by diarrhea and on serum gastrin (GAS), motilin (MOT), and somatostatin (SS) levels in children. Methods:In total, 124 children with upper respiratory tract infection accompanied by diarrhea admitted to the department of pediatrics in our hospital from May 2019 to May 2020 were selected and divided into a study group (n=62) and a reference group (n=62), according to admission number. The reference group children received routine treatment, while the children in the study group were treated with cefuroxime axetil combined with Xingpi Yanger granules. After treatment, each clinical index of the children in both groups was detected to evaluate the clinical efficacy of the different treatment methods.Results: There were no significant differences in gender ratio, average age, mean body temperature, mean duration of diarrhea, average weight, or place of residence between the 2 groups (P>0.05); the total clinical effective rate after treatment in the study group was significantly higher than that in the reference group (P<0.05); the dehydration correction time, antipyretic time, antidiarrheal time, and total treatment time in the study group were all significantly lower than those in the reference group (P<0.001); the serum GAS and MOT levels at T1, T2, and T3 in the study group were significantly lower than those in the reference group (P<0.001), whereas the SS levels at T1, T2, and T3 in the study group were significantly higher than those in the reference group (P<0.001); and the incidence of adverse reactions of the children in the study group was significantly lower than that in the reference group (P<0.05).Conclusions: Cefuroxime axetil combined with Xingpi Yanger granules can significantly lower serum GAS, MOT, and SS levels and shorten treatment time in children with upper respiratory tract infection accompanied by diarrhea, with significant clinical efficacy and high safety, and is thus worthy of application and promotion.

Prediction model of stress ulcer after laparoscopic surgery for colorectal cancer established by machine learning algorithm

“…GAS is a potent hormone that promotes gastric acid secretion. The increase in GAS level may be related to sympathetic nerve excitation caused by trauma, continuous contraction of gastric mucosal blood vessels, vagus nerve choline fiber excitation caused by increased intracranial pressure, use of a strong dose of dehydrating agent and catabolic disorder[ 16 ]. Studies have found that when the level of serum GAS in critically ill patients increases, it will increase gastric acid secretion, resulting in transient small intestinal dysfunction and decreased gastric emptying capacity and gastric pyloric sphincter tension.…”

Influencing mechanism of cupping moxibustion on gastrointestinal function and immune function in patients with functional diarrhea

“…The brain-gut axis is the connecting channel between the gastrointestinal neuroendocrine and the central nervous system, which is closely related to the pathogenesis of functional diarrhea (23). GAS, MLT, and CCK are also in close relation to gastrointestinal function, among which GAS can improve the blood flow of gastric mucosa and enhance gastrointestinal motility (24). MLT can induce the release of pepsin and accelerate gastrointestinal motility and emptying (25)(26)(27).…”

The influence of herbal medicine on serum motilin and its effect on human and animal model: a systematic review

“…In eight of the nine studies, herbal medicines were used alone, and in the remaining study (Ren et al, 2021), herbal medicines and an antibiotic (cefuroxime) were used in combination. Seven studies were conducted on patients with GI diseases or symptoms, one included patients with psychiatric symptoms, and the remaining included healthy individuals.…”

“…Herbal formulas have been used as alternatives to Western medicine for treating GI symptoms such as constipation, diarrhea, and dyspepsia (Zhang et al, 2013;Zhang and Guo, 2015;Ren et al, 2021). Furthermore, several herbal medicines have been reported to affect plasma MLN levels.…”