Effects of cell death-induced proliferation on a cell competition system

Finding a Direct method for a Dynamic process: the DD (Direct and Dynamic) Cell-Tox method

“…Previous studies observed that exposure of a toxic compound to a cell population can be accompanied not only by cell death but also by cell proliferation (known as compensatory proliferation) [16,17]. This situation can be even more pronounced in heterogeneous cell populations; certain cell types can be induced to die while other cell types can be induced to proliferate [16,17].…”

“…Previous studies observed that exposure of a toxic compound to a cell population can be accompanied not only by cell death but also by cell proliferation (known as compensatory proliferation) [16,17]. This situation can be even more pronounced in heterogeneous cell populations; certain cell types can be induced to die while other cell types can be induced to proliferate [16,17]. In complex models such as the liver can be particularly striking, where dying hepatocytes (which make up 80% of the liver) can induce fibroblast proliferation through compensatory proliferation [18,19].…”

Modelling of Tissue Invasion in Epithelial Monolayers

“…To model the competition for space between two cell populations, it is also necessary to include a turnover of cells through stochastic cell birth and death events [ 9 , 12 ]. A crucial factor that regulates cell proliferation is cell growth factor [ 27 , 28 ], so that the probability of cell proliferation for individual cells increases with the cell area [ 29 ].…”

“…Theoretical models are ideal tools to assess the main mechanisms of the competitive cell invasion phenomenon [ 8 ]. Various models have been developed to study the cell competition process, including differential equations of predator–prey interactions [ 7 , 9 ], continuous mechanical models of cell proliferation and death [ 4 , 10 ], the vertex model of the evolution of cell turnover and local topology dynamics [ 11 ], and the cellular Potts model (CPM) of regulation of mechanical contact-dependent competition [ 12 ]. However, it remains elusive how cellular properties affect the speed of cell competition in which winner cells occupy the space following loser cells’ apoptosis.…”

Cell competition: Bridging the scales through cell-based modeling

“…To fill this gap, theoretical frameworks are required to assess how these cellular mechanisms can indeed affect the long-term survival of a cell population. These include continuous models based on differential equations and preypredator interactions 11,12 , continuous models testing the effect of mechanical pressure on cell survival [13][14][15] or cell-based model testing the role of compensatory growth 16 . However, these frameworks either fail to integrate cellular scale information (e.g.…”