Effects of central orexin A on gonadotropins and progesterone secretion in ewes during the luteal phase of the estrous cycle and during anestrus

​Localization of Orexin and its Receptor in Corpus Luteum and in vitro Effect of Orexin on Progesterone Production from Luteal Cells in Buffalo

“…It is well known fact that the corpus luteum, ephemeral endocrine structure that grows after ovulation, exerts a crucial role in the hormonal events occurring during the estrous cycle. In vitro studies on the effects of orexin in luteal cells of ovary has been carried out earlier in swine Nitkiewicz et al (2014), Ragioniei et al (2018 and in ewes Kirsz et al (2019). In these studies, it was observed that orexin affects steroidogenesis in ovarian cells and the effects varies with concentration.…”

“…The OXA and its receptors in luteal cells and their role in P 4 production was recorded by Mesen et al (2015). In ewes, centrally administrated OXA decreased the secretion of progesterone in the luteal phase (Kirsz et al, 2019). Effect of orexin on P4 secretion from luteal cells of rats (Cataldi et al, 2012) and swine (Basini et al, 2018) has been recorded.…”

Ingestive Peptides – An Emerging Tool for Diagnostics and Therapeutics: A Review

“…Orexin-A can regulate the reproductive system in ewes. It reduces the plasma level of LH, FSH and progesterone under natural physiological conditions (intact, non-steroid-primed ewes) (Kirsz et al 2019). The orexinic system can engage in placental growth and development and in the regulation of its steroidogenic capacity through endocrine, paracrine and/or autocrine mechanisms (Dall'Aglio et al 2012).…”