Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat

Gulec, Guldal; Isbil-Buyukcoskun, Naciye; Kahveci, Nevzat

doi:10.1016/j.npep.2010.02.002

Cited by 27 publications

(14 citation statements)

References 33 publications

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“…To test the possibility that VTA amylin receptor activation suppresses other motivated ingestive behaviors, water intake as well as intake of a non-nutritive sweetener are evaluated after VTA injection of an amylin receptor agonist. Finally, an important consideration is that some feeding-related peptides can induce anxiety-like behaviors in rodents (Anderberg et al, 2016; Gulec et al, 2010; To and Bagdy, 1999), and hypophagia can be induced by anxiety-like responses (Blasio et al, 2014; Strongman, 1965). Therefore, to rule out the possibility that the suppression of feeding/motivated behaviors by VTA amylin is due to anxiogenesis, the effect of VTA amylin receptor activation on anxiety-like behaviors is tested in two separate paradigms.…”

Section: Introductionmentioning

confidence: 99%

Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior

et al. 2017

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Amylin is produced in the pancreas and the brain, and acts centrally to reduce feeding and body weight. Recent data show that amylin can act in the ventral tegmental area (VTA) to reduce palatable food intake and promote negative energy balance, but the behavioral mechanisms by which these effects occur are not fully understood. The ability of VTA amylin signaling to reduce intake of specific palatable macronutrients (fat or carbohydrate) was tested in rats in several paradigms, including one-bottle acceptance tests, two-bottle choice tests, and a free-choice diet. Data show that VTA amylin receptor activation with the amylin receptor agonist salmon calcitonin (sCT) preferentially and potently reduces intake of fat, with more variable suppression of sucrose intake. Intake of a non-nutritive sweetener is also decreased by intra-VTA administration of sCT. As several feeding-related signals that act in the mesolimbic system also impact motivated behaviors besides feeding, we tested the hypothesis that the suppressive effects of amylin signaling in the VTA extend to other motivationally relevant stimuli. Results show that intra-VTA sCT reduces water intake in response to central administration of the dipsogenic peptide angiotensin II, but has no effect on ad libitum water intake in the absence of food. Importantly, open field and social interaction studies show that VTA amylin signaling does not produce anxiety-like behaviors. Collectively, these findings reveal a novel ability of VTA amylin receptor activation to alter palatable macronutrient intake, and also demonstrate a broader role of VTA amylin signaling for the control of motivated ingestive behaviors beyond feeding.

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Section: Introductionmentioning

confidence: 99%

Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior

et al. 2017

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“…Previous studies revealed that glucagon-like peptide 1 (Glp-1) acts directly through the Glp-1 receptor (GLP-1R) pathway to attenuate the effect of seizures [35]. Glp-1R deficient mice have enhanced seizure severity and neuronal excitability [36]. NPY was also known to be an important modulator of excitability in the central nervous system, and overexpression of NPY in the rat hippocampus could mediate anticonvulsant effect [37], [38].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Analysis of the Hippocampus in Novel Rat Model of Febrile Seizures

Wang

Yang

et al. 2014

PLoS ONE

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Febrile seizures (FS) are the most common type of convulsive events in infants and young children, but the precise underlying genetic mechanism remains to be explored. To investigate the underlying pathogenic factors in FS and subsequent epilepsy, alterations in gene expression between the two new strains of rats (hyperthermia-prone [HP] vs hyperthermia-resistant [HR]), were investigated by using the Whole Rat Genome Oligo Microarray. This process identified 1,140 differentially expressed genes (DEGs; 602 upregulated and 538 downregulated), which were analyzed to determine significant Gene Ontology (GO) categories, signaling pathways and gene networks. Based on the GO analyses, the modified genes are closely related to various FS pathogenesis factors, including immune and inflammatory responses and ion transport. Certain DEGs identified have not been previously examined in relation to FS pathogenesis. Among these genes is dipeptidyl peptidase 4 (DPP4), a gene closely linked to interleukin 6 (IL-6), which played a key role in the gene network analysis. Furthermore, sitagliptin, a DPP4 inhibitor significantly decreased epileptic discharge in rats, observed via electroencephalogram, suggesting an important role for DPP4 in FS. The effectiveness of sitagliptin in reducing seizure activity may occur through a mechanism that stabilizes cellular Ca2+ homeostasis. In addition, DPP4 expression may be regulated by DNA methylation. The hippocampal gene expression profiles in novel rat models of FS provides a large database of candidate genes and pathways, which will be useful for researchers interested in disorders of neuronal excitability.

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“…Physiologically, however, emotion and mood under fed conditions will be determined by the presence of a variety of gut hormones such as PYY, GLP-1 and GLP-2 that are released postprandially. Thus, GLP-1 has been found to enhance anxiety-related behaviour [141][142][143], while GLP-2 attenuates depression-like behaviour [144]. Gut hormones whose release from the enteroendocrine cells is likely to be regulated by the gut microbiota thus provide a constant stream of interoceptive input from the gut to the brain.…”

Section: Npy Pyy and Other Gut Peptides In The Interoceptive Regulatmentioning

confidence: 99%

Neuropeptides and the Microbiota-Gut-Brain Axis

Holzer

Farzi

2014

Advances in Experimental Medicine and Biology

373

290

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Neuropeptides are important mediators both within the nervous system and between neurons and other cell types. Neuropeptides such as substance P, calcitonin gene-related peptide and neuropeptide Y (NPY), vasoactive intestinal polypeptide, somatostatin and corticotropin-releasing factor are also likely to play a role in the bidirectional gut-brain communication. In this capacity they may influence the activity of the gastrointestinal microbiota and its interaction with the gutbrain axis. Current efforts in elucidating the implication of neuropeptides in the microbiota-gutbrain axis address 4 information carriers from the gut to the brain (vagal and spinal afferent neurons; immune mediators such as cytokines; gut hormones; gut microbiota-derived signalling molecules) and 4 information carriers from the central nervous system to the gut (sympathetic efferent neurons; parasympathetic efferent neurons; neuroendocrine factors involving the adrenal medulla; neuroendocrine factors involving the adrenal cortex). Apart from operating as neurotransmitters, many biologically active peptides also function as gut hormones. Given that neuropeptides and gut hormones target the same cell membrane receptors (typically G proteincoupled receptors), the two messenger roles often converge in the same or similar biological implications. This is exemplified by NPY and peptide YY (PYY), two members of the PP-fold peptide family. While PYY is almost exclusively expressed by enteroendocrine cells, NPY is found at all levels of the gut-brain and brain-gut axis. The function of PYY-releasing enteroendocrine cells is directly influenced by short chain fatty acids generated by the intestinal microbiota from indigestible fibre, while NPY may control the impact of the gut microbiota on inflammatory processes, pain, brain function and behaviour. Although the impact of neuropeptides on the interaction between the gut microbiota and brain awaits to be analysed, biologically active peptides are likely to emerge as neural and endocrine messengers in orchestrating the microbiotagut-brain axis in health and disease.

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Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat

Cited by 27 publications

References 33 publications

Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior

Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior

Transcriptome Analysis of the Hippocampus in Novel Rat Model of Febrile Seizures

Neuropeptides and the Microbiota-Gut-Brain Axis

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