Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid‐based bone scaffolds under hydrolytic conditions

Donate, Ricardo; Monzón, Mario; Alemán‐Domínguez, María Elena; Rodrı́guez-Esparragón, Francisco

doi:10.1002/jbm.b.35162

“…Kunststoffkomposite enthalten neben den Polymeren Füllstoffe wie Calciumphosphat oder Calciumcarbonat. Biokompatibilitätsuntersuchungen zeigen verbesserte pH‐Charakteristika dieser Kunststoffkomposite gegenüber den reinen Polymeren [24–27].…”

Section: Stand Des Wissensunclassified

Antibacterial polymer composites for implants made of polylactide and polyetheretherketone with zinc oxide: Properties, degradation and efficacy

Rode,

Oehler,

Brauch

et al. 2023

Materialwissenschaft Werkst

0

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Das Ziel dieser Studie war, zur Infektionsvermeidung einen antibakteriellen Wirkstoff in Implantate aus Kunststoff zu integrieren und das Alterungsverhalten dieser Kunststoffkomposite in physiologischer Lösung in Abhängigkeit von Füllstoffart und ‐anteil sowie der Prozessparameter zu untersuchen. Der bereits beim Compoundieren in den Kunststoff eingearbeitete Wirkstoff soll im Körper über einen langen Zeitraum wirksam bleiben. Unter Variation der Prozessbedingungen in der Schmelzeverarbeitung wurden Kunststoffkomposite aus einem biodegradierbaren Polylactid (PLA) mit Tricalciumphosphat (TCP) und Zinkoxid (ZnO) als antibakteriellem Wirkstoff versetzt. In ein nichtabbaubares Polyetheretherketon (PEEK) wurden Hydroxylapatit (HAP) und Zinkoxid eingearbeitet. Die Werkstoffeigenschaften der Kunststoffkomposite wurden charakterisiert und in Hinblick auf ihr in‐vitro‐Verhalten untersucht. Die Untersuchungen erfolgten durch Gelpermeationschromatographie (GPC), Differenzialkalorimetrie (DSC), Zugprüfungen, Erfassung der Massenänderung während der Einlagerung und den Colony Forming Units Test (CFU). Über die untersuchte Einlagerungsdauer von 9 Monaten in phosphatgepufferter Salzlösung (PBS) bei 37 °C zeigten die Kunststoffkomposite eine antibakterielle Wirksamkeit gegenüber Escherichia coli.

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“…Green nanopolymer-based green nanocomposites have been applied in various biomedical applications [166], [167]. For application in drug delivery, nanomaterial degradation under hydrolytic conditions has been found indispensable [168], [169]. The synthesis, compatibility, hydrophobicity, degradation, in-situ erosion, etc.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Degradable Green Polymers, Green Nanopolymers and Green Nanocomposites Derived from Natural Systems: Statistics and Headways

Kausar,

Ahmad

2023

NH

0

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Nowadays, actively researching and developing degradable green materials are efficient means to move towards the future advanced technologies and industries. In this article, we review the state of the art in important aspects of degradable green polymers especially green nanopolymers from natural sources and derived nanomaterials. Consequently, the fundamentals, cataloguing and properties of degradable green polymers or green nanopolymers obtained from natural resources have been presented. Green nanopolymers and derivative green nanocomposites are natural degradable materials. In this article, we also deliver numerous technological applications of the degradable green nanopolymers and derived materials such as transient electronics, film/coating and membrane/packaging, environmental protection and sustainability, and biomedical applications. The resulting green nanocomposites have been found effective to resolve current ecological issues. Moreover, the challenges and future of the natural degradable green nanopolymers and green nanocomposites have been investigated. However, the research and advancement of technical degradable materials with industrial and commercial applications yet have along way to go.

show abstract

“…Green nanopolymer-based green nanocomposites have been applied in various biomedical applications [166], [167]. For application in drug delivery, nanomaterial degradation under hydrolytic conditions has been found indispensable [168], [169]. The synthesis, compatibility, hydrophobicity, degradation, in-situ erosion, etc.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Degradable Green Polymers, Green Nanopolymers and Green Nanocomposites Derived from Natural Systems: Statistics and Headways

Kausar

¹

,

Ahmad

²

2023

Nano-Horizons

1

0

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Nowadays, actively researching and developing degradable green materials are efficient means to move towards the future advanced technologies and industries. In this article, we review the state of the art in important aspects of degradable green polymers especially green nanopolymers from natural sources and derived nanomaterials. Consequently, the fundamentals, cataloguing and properties of degradable green polymers or green nanopolymers obtained from natural resources have been presented. Green nanopolymers and derivative green nanocomposites are natural degradable materials. In this article, we also deliver numerous technological applications of the degradable green nanopolymers and derived materials such as transient electronics, film/coating and membrane/packaging, environmental protection and sustainability, and biomedical applications. The resulting green nanocomposites have been found effective to resolve current ecological issues. Moreover, the challenges and future of the natural degradable green nanopolymers and green nanocomposites have been investigated. However, the research and advancement of technical degradable materials with industrial and commercial applications yet have a long way to go.

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Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid‐based bone scaffolds under hydrolytic conditions

Cited by 8 publications

References 76 publications

Antibacterial polymer composites for implants made of polylactide and polyetheretherketone with zinc oxide: Properties, degradation and efficacy

Antibacterial polymer composites for implants made of polylactide and polyetheretherketone with zinc oxide: Properties, degradation and efficacy

Degradable Green Polymers, Green Nanopolymers and Green Nanocomposites Derived from Natural Systems: Statistics and Headways

Degradable Green Polymers, Green Nanopolymers and Green Nanocomposites Derived from Natural Systems: Statistics and Headways

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