Effects of cerestat and NBQX on functional and morphological outcomes in rat focal cerebral ischemia

Pitsikas, Nikolaos; Brambilla, Alessandro; Besozzi, C; Bonali, P.; Fodritto, F.; Grippa, Nicoletta; Scandroglio, Anna Mara; Borsini, Franco

doi:10.1016/s0091-3057(00)00469-x

Cited by 13 publications

(8 citation statements)

References 18 publications

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“…Following HI, the p‐Akt/t‐Akt and p‐GSK‐3β/t‐GSK‐3β levels decreased significantly in our vehicle control group, which indicates that these molecules play an important role in the pathology of HI. The reduction of p‐Akt and p‐GSK‐3β levels was found to cause an increase in cleaved caspase‐3 levels indicating the involvement of apoptotic signaling . Our results verified that TDZD‐8 reduced brain injury following HI injury in neonatal mice and support that pretreatment with TDZD‐8 elicited neuroprotection through restoring p‐Akt/t‐Akt and p‐GSK‐3β/t‐GSK‐3β levels which led to suppression of cleaved caspase‐3‐mediated apoptotic signaling.…”

Section: Discussionsupporting

confidence: 80%

“…The reduction of p-Akt and p-GSK-3β levels was found to cause an increase in cleaved caspase-3 levels indicating the involvement of apoptotic signaling. 44,45 Our results verified that TDZD-8 reduced brain injury following HI injury in neonatal mice and support that pretreatment with TDZD-8 elicited neuroprotection through restoring p-Akt/t-Akt and p-GSK-3β/t-GSK-3β levels which led to suppression of cleaved caspase-3-mediated apoptotic signaling.…”

Section: Discussionsupporting

confidence: 77%

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GSK‐3β inhibitor TDZD‐8 reduces neonatal hypoxic‐ischemic brain injury in mice

et al. 2017

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 77%

GSK‐3β inhibitor TDZD‐8 reduces neonatal hypoxic‐ischemic brain injury in mice

et al. 2017

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“…Every time that its injured paw slipped between the wire as it moved along the grid with a weight‐bearing step was recorded as a foot‐fault. The total number of steps ( n = 30) and the number of foot‐faults for the injured hindlimb were counted (Pitsikas et al. , 2001; Zhang et al.…”

Section: Methodsmentioning

confidence: 99%

Embryonic and adult stem cells promote raphespinal axon outgrowth and improve functional outcome following spinal hemisection in mice

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Rupa

Garbossa³

et al. 2009

Eur J of Neuroscience

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Spinal cord injury (SCI) often results in permanent neurological deficits below the injury site. Serotonergic raphespinal projections promote functional recovery after SCI, but spontaneous regeneration of most severed axons is limited by the glial cyst and scar that form at the lesion site. Stem cell (SC) transplantation offers a promising approach for inducing regeneration through the damaged area. Here we compare the effects of transplantation of embryonic neural precursors (NPs) or adult mesenchymal SCs, both of which are potential candidates for SC therapy. The spinal cord was hemisected at the L2 neuromer in adult mice. Two weeks post-injury, we transplanted neural precursors or mesenchymal SCs into the cord, caudal to the hemisection. Injured mice without a graft served as controls. Mice were tested for functional recovery on a battery of motor tasks, then killed and analysed for survival of grafted cells, for effects of engraftment on the local cellular environment and for the sprouting of serotonergic axons. Both types of SCs survived and were integrated into the host tissue, but only the NPs expressed neuronal markers. All transplanted animals displayed an increased number of serotonin-positive fibres caudal to the hemisection, compared with untreated mice. And both cell types led to improved motor performance. These results point to a therapeutic potential for such cell grafting.

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“…The test has been used in animal models of ischemic injury (Modo et al, 2000;Pitsikas et al, 2001;Lubics et al, 2005), spinal cord lesion (Himes et al, 2006), and pyramidotomy (Starkey et al, 2005). Although the main concern in these cases was to observe the asymmetry of foot failure from inaccurate paw placement leading to slipping through the grid, the footfault test has potential use in the 0165-0270/$ -see front matter © 2008 Elsevier B.V. All rights reserved.…”

Section: Introductionmentioning

confidence: 99%