Effects of Certain Triazenes on Chick Embryos and on Tumors Explanted to the Chorioallantois.

Dagg, C. P.; Karnofsky, David A.; Stock, C. Chester; Lacon, Corinne R.; Roddy, Jacqueline

doi:10.3181/00379727-90-22074

Cited by 20 publications

(4 citation statements)

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“…The application of dcHSA‐Gd‐Dox was studied in vivo in tumor xenografts grown on the chorioallantoic membrane (CAM) of fertilized chick eggs as a preclinical in vivo model ( Figure A). Because of its simplicity and direct accessibility, the CAM is an attractive preclinical in vivo model with proven applicability in tumor‐related research to explore, for example, tumor biology, growth, and angiogenesis . It enables rapid screening of substances with reliable assessment of substance activity, distribution, and toxicity in an in vivo environment and it has been widely implemented for the evaluation of drug delivery and kinetics of, for example, drug conjugates, prodrugs, or nanoparticles .…”

Section: Resultsmentioning

confidence: 99%

High‐Contrast Magnetic Resonance Imaging and Efficient Delivery of an Albumin Nanotheranostic in Triple‐Negative Breast Cancer Xenografts

Hafner

Raabe

et al. 2019

Advanced Therapeutics

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Triple-negative breast cancer (TNBC) is a fast growing and strong metastasizing tumor, which presents almost no cellular receptors that can be addressed by targeted therapeutics. In addition, TNBC is often characterized by high tumor grading, fast growth rates, and early metastasis. Therefore, multifunctional drug carriers allowing efficient drug delivery and bioimaging to treat and track TNBC tissue in vivo would be highly desirable. A human serum albumin-based polyethylene glycol copolymer (dcHSA-Gd-Dox) is synthesized combining multiple copies of the chemotherapeutic drug doxorubicin and gadolinium (III) (Gd(III))-based magnetic resonance imaging (MRI) contrast agent. The biodegradable albumin-based nanocarriers reveal high-contrast tumor imaging and efficient drug delivery in a preclinical TNBC xenograft model, where the xenografts are grown on the chorioallantoic membrane of fertilized chick eggs. dcHSA-Gd-Dox is injected intravenously, and the distribution of the compound is monitored by MRI and inductively coupled optical plasma emission spectrometry. dcHSA-Gd-Dox is rapidly taken up into MDA-MB-231 cells and exhibits significant cytotoxic efficacy. dcHSA-Gd-Dox combines high tissue enrichment with low systemic toxicity and high-contrast MRI rendering it an attractive nanotheranostic for TNBC.

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Section: Resultsmentioning

confidence: 99%

High‐Contrast Magnetic Resonance Imaging and Efficient Delivery of an Albumin Nanotheranostic in Triple‐Negative Breast Cancer Xenografts

Hafner

Raabe

et al. 2019

Advanced Therapeutics

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“…Teratogenic activity for 3,3-dimethyl-1-phenyltriazene on chicken embryos [3] and antitumor activity of this compound for sarcoma 180 and leukemia strains L 82, 1210, and 5471 [4,5] were demonstrated first in 1955. 1-(4-Tolyl)-and 1-(4-nitrophenyl)-3,3-dimethyltriazenes were tested on these same strains [4,5].…”

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confidence: 97%

“…2 Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of Armenia, Yerevan, Armenia. 3 Deceased. [11 -14].…”

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confidence: 99%

Antitumor activity of imidazole derivatives: dacarbazine and the new alkylating agent imidazene (Review)

Iradyan

Stepanyan

et al. 2010

Pharm Chem J

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The physicochemical properties and antitumor activity of dacarbazine, its analogs, and the new alkylating agent imidazene are reviewed. It is shown that the activity of dacarbazine is superior to most of its analogs. Imidazene exhibits an advantage over dacarbazine with respect to both stability and activity and can be used for the treatment of malignant melanoma and sarcoma of soft tissues and in combined chemotherapy.

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“…After such human tumors have grown in the conditioned animal, they can be passed serially in the embryonated egg (Dagg et at., 1955;Harris, 1958). The implanted and embryonated egg offers a biological system which serves as a primary screen for new antitumor agents.…”

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confidence: 99%

Hadacidin, a New Growth-Inhibitory Substance in Human Tumor Systems

Kaczka¹,

Gitterman²,

Dulaney³

et al. 1962

Biochemistry

115

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Effects of Certain Triazenes on Chick Embryos and on Tumors Explanted to the Chorioallantois.

Cited by 20 publications

References 0 publications

High‐Contrast Magnetic Resonance Imaging and Efficient Delivery of an Albumin Nanotheranostic in Triple‐Negative Breast Cancer Xenografts

High‐Contrast Magnetic Resonance Imaging and Efficient Delivery of an Albumin Nanotheranostic in Triple‐Negative Breast Cancer Xenografts

Antitumor activity of imidazole derivatives: dacarbazine and the new alkylating agent imidazene (Review)

Hadacidin, a New Growth-Inhibitory Substance in Human Tumor Systems

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