Effects of ceruletide on the dopamine receptor-adenylate cyclase system in striatum and frontal cortex of rats chronically treated with haloperidol

Hatta, Yuko; Hatta, Shinichi; Saito, Toshikazu

doi:10.1007/bf02244642

Cited by 12 publications

(1 citation statement)

References 52 publications

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“…This system is of particular relevance, as all DA receptors are either positively or negatively linked to it. Increased cerebrospinal fluid cAMP levels have been observed in SCZ, 67 whereas normalization of these levels has been associated with AP treatment 67,68 and response to AP treatment. 69 The effect of D3 on this system has been derived through in vitro experiments.…”

Section: Drd3 Polymorphisms and Clozapine Responsementioning

confidence: 41%

Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant

et al. 2009

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D2 blockade has been implicated in having a central role in antipsychotic response. However, treatment refractoriness, in spite of complete D2 blockade, as well as the efficacy of clozapine (CLZ) in a portion of this patient population, indicates the involvement of other factors as well. Several lines of evidence suggest a role for D3. Furthermore, an earlier meta-analysis by Jönsson et al. (2003) (n ¼ 233) suggested a role for genetic variation in the D3 gene. Relevant to this study, Jönsson et al. found the Ser allele of the D3 serine-to-glycine substitution at amino acid position 9 (Ser9Gly) polymorphism to be associated with worse CLZ response compared with the Gly allele. In this study, we attempt to validate these findings by performing a meta-analysis in a much larger sample (n ¼ 758). Eight other variants were also tested in our own sample to explore the possible effect of other regions of the gene. We report a negative but consistent trend across individual studies in our meta-analysis for the DRD3 Ser allele and poor CLZ response. A possible minor role for this single-nucleotide polymorphism cannot be disregarded, as our sample size may have been insufficient. Other DRD3 variants and haplotypes of possible interest were also identified for replication in future studies.

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Section: Drd3 Polymorphisms and Clozapine Responsementioning

confidence: 41%

Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant

et al. 2009

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Effects of ceruletide on perioral movements and the dopamine receptor-adenylate cyclase system in rats chronically treated with fluphenazine

1996

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The effects of repeated administration of ceruletide (100 micrograms/kg/perday, i.p. for 3 days) on perioral movements and the striatal dopamine receptor adenylate cyclase system were examined in rats chronically treated with fluphenazine enanthate (FPZ) (25 mg/kg i.m. every 3 weeks for 30 weeks) and sesame oil-treated (control) rats. After the tenth injection of fluphenazine, the rats started to display five types of perioral movements (teeth chattering, chewing, tongue protrusion, mouth opening and perioral tremors). Moreover, increases in SCH23390 binding and spiperone binding to striatal membranes, were found in the FPZ-treated rats. Furthermore, dopamine receptor-coupled adenylate cyclase activity was potentiated in striatal membranes. High amplitude EMG discharges (8-10 Hz), recorded from the masseter in the FPZ-treated rats occurred concurrently with perioral tremors. Repeated ceruletide (CLT) injections abolished perioral movements, and reversed both the elevated SCH23390 binding and the dopamine stimulated adenylate cyclase (AC) activity to the control level. The effect of CLT on perioral movements, D1 receptors and dopamine-stimulated AC activity continued for 6 days after the final CLT injection. These findings suggest that systemically administered CLT affects the D1 receptor adenylate cyclase system and that an increase of the D1 receptor mechanism may play an important role in the pathogenesis of tardive dyskinesia.

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An increase in [ 3 H]SCH23390 binding in the cerebral cortex of postmortem brains of chronic schizophrenics

Domyo

Kurumaji

Toru

2001

Journal of Neural Transmission

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Abnormalities in neural transmission of dopamine play an important role in development of schizophrenia. Dopamine 1 (D1)-like receptors in 16 areas of the cerebral cortex were measured in the postmortem brains of 13 schizophrenics and 10 controls, using [3H]SCH23390 as a ligand for receptor binding. The specific [3H]SCH23390 bindings were statistically significantly increased in the medial and inferior cortex (Brodmann Area (BA) 20 & 21) and superior parietal cortex (BA 7) of schizophrenic patients, compared to those of the controls. The increases were also marked in the cerebral cortices of off-drug cases of patients with schizophrenia, who had not received antipsychotic drugs for more than 40 days before death. These results suggest that there are changes in dopaminergic transmission through the D1 receptors in the parieto-temporal cortex of schizophrenia, and that the altered functions are involved in the pathophysiology of the disease.

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Effects of ceruletide on the dopamine receptor-adenylate cyclase system in striatum and frontal cortex of rats chronically treated with haloperidol

Cited by 12 publications

References 52 publications

Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant

Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant

Effects of ceruletide on perioral movements and the dopamine receptor-adenylate cyclase system in rats chronically treated with fluphenazine

An increase in [ 3 H]SCH23390 binding in the cerebral cortex of postmortem brains of chronic schizophrenics

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