2002
DOI: 10.1016/s0014-2999(02)01305-5
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Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat

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Cited by 114 publications
(98 citation statements)
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“…In a murine model of OVA-induced chronic obstructive pulmonary disease, A2a activation reduced influx of leukocytes into the BAL. Similar to our findings, pretreatment with CGS-21680 also reduced LPS-induced PMN infiltration (58,59) and cytokine release into the alveolar airspace, although not statistically significant in one study (59).…”
Section: Discussionsupporting
confidence: 90%
“…In a murine model of OVA-induced chronic obstructive pulmonary disease, A2a activation reduced influx of leukocytes into the BAL. Similar to our findings, pretreatment with CGS-21680 also reduced LPS-induced PMN infiltration (58,59) and cytokine release into the alveolar airspace, although not statistically significant in one study (59).…”
Section: Discussionsupporting
confidence: 90%
“…Immunosuppressive and anti-inflammatory properties observed after activation of A 2A receptors in the airways are well documented. Indeed, it was recently shown that the treatment with CGS21680, a selective agonist of the adenosine A 2A receptor, attenuates acute carrageenan-induced pleural and lung inflammation [33] and allergic pulmonary inflammation in rats [13]. Some studies also demonstrated that A 2A receptor activation may cause suppression of the recruitment of T lymphocytes to the lungs [34,35].…”
Section: Discussionmentioning
confidence: 99%
“…The potential role of adenosine triphosphate and adenosine in the pathogenesis of asthma has been supported by the bronchoconstrictor effects observed after their topical administration in the airways of patients with asthma and chronic obstructive pulmonary disease but not in those of healthy subjects [9][10][11][12]. In contrast, experimental data demonstrated that adenosine and its analogues have also been shown to exert protective and anti-inflammatory effects in the airways, reducing the leukocyte cell count in bronchoalveolar lavage fluid (BALF) and decreases airway remodelling in murine models of asthma, an effect related to adenosine A 2 receptors activation [13,14].…”
Section: Introductionmentioning
confidence: 99%
“…The antiinflammatory and tissue-protective properties of A 2A R agonists have not yet been adequately tested in clinical trials because the A 2A R has a widespread tissue and cell-type distribution, and therefore, activating this receptor might lead to unwanted side effects. The A 2A R activation mediates inhibition of platelet aggregation, hypotension and a variety of effects within the central nervous system [10,39,41]. In this respect, considering the low concentration of the A 2A R agonist and the inability of the A 2B R antagonist to penetrate the cell membrane as well as the blood-brain barrier, the concept of the agonist/antagonist combination could overcome these therapy limiting side effects.…”
Section: Discussionmentioning
confidence: 99%