Effects of Chailong Jieyu Pill on Behavior, Monoamine Neurotransmitters, and Corticosteroid Receptors in a Rat Model of Anxiety Disorder

Feng, Guangkui; Ma, Xiao‐Jun; Chen, Yin-yi; Bian, Guangrong; Yang, Chao; Gu, Baodong

doi:10.1155/2018/5489215

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…81,82 In the in vivo study, the levels of DA and 5-HT in the serum, hippocampus, mPFC, and amygdala of mice in the anxious state were higher than those of the control mice. These results are in agreement with several studies on different anxiety models, which confirmed elevated 5-HT and DA levels 83 EPM, 84 and uncertain empty bottle stimulation 85 induced anxious rodents. In addition, in vivo data demonstrated that this abnormal increase in 5-HT and DA levels was restored after treatment with RC extract, validating the predicted important role of dopaminergic synapses and serotonergic synapses in C. chinensis Franch.…”

Section: Discussionsupporting

confidence: 93%

Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis

Qi¹,

Ni²,

Xia³

et al. 2022

DDDT

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Background: Serious mental illness is a disease with complex etiological factors that requires multiple interventions within a holistic disease system. With heat-clearing and detoxifying effects, Coptis chinensis Franch. is mainly used to treat serious mental illness. Aim of the Study:To explore the underlying mechanisms and therapeutic effect by which Coptis chinensis Franch. treats serious mental illnesses at a holistic level. Methods: A viable network pharmacology approach was adopted to obtain the potential active ingredients of Coptis chinensis Franch., and serious mental illnesses-related targets and signaling pathways. The interactions between crucial target HTR2A and constituents were verified by molecular docking, and the dynamic behaviors of binding were studied by molecular dynamics simulation. In addition, the anti-anxiety effect of Rhizoma Coptidis (the roots of Coptis chinensis Franch.) extract on lipopolysaccharide-stimulated mice was verified. The anxiety-like behavior was measured through the elevated plus-maze test, light-dark box test, and open field test. Radioimmunoassays detected the levels of interleukin-1β, tumor necrosis factor-α, interleukin-10, interleukin-4, 5-hydroxytryptamine, and dopamine in the serum, hippocampus, medial prefrontal cortex, and amygdala. Meanwhile, immunohistochemistry protocols for the assessment of neuronal loss (neuron-specific nuclear protein) and synaptic alterations (Synapsin I) were performed in the hippocampus. Results: Based on scientific analysis of the established networks, serious mental illnesses-related targets mostly participated in the calcium signaling pathway, cyclic adenosine monophosphate signaling pathway, mitogen-activated protein kinase signaling pathway, serotonergic and dopaminergic synapse. Molecular docking and molecular dynamics simulation studies illustrated that berberine, epiberberine, palmatine, and coptisine presented favorable binding patterns with HTR2A. The in vivo experiments confirmed that Rhizoma Coptidis extract ameliorated anxiety-like behaviors by improving the survival of neurons, regulating synaptic plasticity, and inhibiting neuroinflammation. Conclusion:These findings in the present study led to potential preventative and therapeutic strategies for serious mental illnesses with traditional Chinese medicine.

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Section: Discussionsupporting

confidence: 93%

Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis

Qi¹,

Ni²,

Xia³

et al. 2022

DDDT

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“…For understanding the mechanism of action of a TCM formula at the systems level, it is essential to integrate the molecular mechanism into the system-wide mechanism of action. The representative TCM formulas in depression treatment are, but no limited to, Xiao-Yao-San (Chen et al, 2008), Kai-Xin-San (Fu et al, 2020), Jie-Yu-Wan (Feng et al, 2018), Shu-Yu-San (Chen et al, 2012), Chaihu-Jia-Longgu-Muli-Tang (Li et al, 2011), and so on. CUMS, chronic unpredictable mild stress; CSDS, chronic social defeat stress; CMS, chronic mild stress; SDM, social defeat model; CORT, corticosterone; CUS, chronic unpredictable stress; WKT, Wistar Kyoto; LPS, lipopolysaccharides.…”

Section: The Hpa Axismentioning

confidence: 99%

Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems

Huang

Cheng

et al. 2020

Front. Pharmacol.

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Depression is a multigenetic or multifactorial syndrome. The central neuron system (CNS)orientated, single target, and conventional antidepressants are insufficient and far from ideal. Traditional Chinese Medicine (TCM) has historically been used to treat depression up till today, particularly in Asia. Its holistic, multidrug, multitarget nature fits well with the therapeutic idea of systems medicine in depression treatment. Over the past two decades, although efforts have been made to understand TCM herbal antidepressants at the molecular level, many fundamental questions regarding their mechanisms of action remain to be addressed at the systems level in order to better understand the complicated herbal formulations in depression treatment. In this Mini Review, we review and discuss the mechanisms of action of herbal antidepressants and their acting targets in the pathological systems in the brain, such as monoamine neurotransmissions, hypothalamic-pituitary-adrenal (HPA) axis, neurotropic factor brain-derived neurotrophic factor (BDNF) cascade, and glutamate transmission. Some herbal molecules, constituents, and formulas are highlighted as examples to discuss their mechanisms of action and future directions for comprehensive researches at the systems level. Furthermore, we discuss pharmacological approaches to integrate the mechanism of action from the molecular level into the systems level for understanding of systems pharmacology of TCM formulations. Integration of the studies at the molecular level into the systems level not only represents a trend in TCM study but also promotes our understanding of the system-wide mechanism of action of herbal antidepressant formulations.

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“…In addition, people with poor physique often have a longer course of disease. In fact, the stagnation of liver-Qi and stagnation of Qi are crucial for the onset of this disease [ 6 ]. Thus, in TCM, the stagnation of the liver-Qi syndrome type and liver stagnation transforming into the fire type are common.…”

Section: Introductionmentioning

confidence: 99%

Altered Default Mode Network and Salience Network Functional Connectivity in Patients with Generalized Anxiety Disorders: An ICA‐Based Resting‐State fMRI Study

Xiong

Guo

Shi

2020

Evidence-Based Complementary and Alternative Medicine

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This study aimed to explore the role of the default mode network (DMN) and salience network (SN) in the assessment of pathophysiology of generalized anxiety disorder (GAD) through analyzing the characteristics of internal function connectivity (FC) and to investigate the relationship of FC with Hamilton anxiety (HAMA) scale scores in untreated GAD patients during a resting-state functional magnetic resonance imaging (rs-fMRI). Rs-fMRI and HAMA scale scoring were performed in 51 GAD patients (31 GAD patients with liver stagnation transforming into fire type and 20 GAD patients with stagnation of liver-Qi syndrome type) and 20 healthy controls. Spearman correlation analysis was performed to assess the association between HAMA scores and abnormal brain FC. Compared with healthy controls, the FC of the right medial prefrontal gyrus of the DMN and the right superior temporal gyrus of the SN increased significantly in the GAD patients (P<0.001). However, the FC of the left middle frontal gyrus and bilateral medial superior frontal gyrus of the SN reduced significantly in the GAD patients with stagnation of liver-Qi syndrome type as compared with healthy controls and GAD patients with liver stagnation transforming into fire type (P<0.001). There was no relationship between abnormal brain FC and HAMA scores. In conclusion, the FC of the DMN and SN may be abnormal in the GAD patients at the resting state. The aberrant FC of some crucial brain regions of these networks may contribute to the pathophysiology of GAD.

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Effects of Chailong Jieyu Pill on Behavior, Monoamine Neurotransmitters, and Corticosteroid Receptors in a Rat Model of Anxiety Disorder

Cited by 10 publications

References 13 publications

Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis

Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis

Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems

Altered Default Mode Network and Salience Network Functional Connectivity in Patients with Generalized Anxiety Disorders: An ICA‐Based Resting‐State fMRI Study

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