Effects of changing from sevoflurane to desflurane on the recovery profile after sevoflurane induction: a randomized controlled study

The Effects of Switching from Sevoflurane to Short-Term Desflurane prior to the End of General Anesthesia on Patient Emergence and Recovery: A Randomized Controlled Trial

“…We observed no significant change in the MAP and HR after anesthetic switching, which is also consistent with previous reports [ 14 ]. A rapid increase in end-tidal desflurane concentration by >5% was found to induce a transient increase in the HR and blood pressure by inducing sympathetic nerve stimulation [ 24 ].…”

“…The result of this study is consistent with that of previous studies on the intraoperative switching use of inhalation anesthetic agents. Mikuni et al demonstrated that sevoflurane for anesthesia induction and switching to desflurane for anesthesia maintenance within 5 minutes after the induction improves the patients' emergence and recovery profile [ 14 ]. Compared with previous study, our study showed that patients could be awakened faster even though the much more extended use of sevoflurane (approximately 5 and 180 minutes, respectively) and relatively shorter use of desflurane (approximately 100 and 30 minutes, respectively).…”

“…Failure to do so may reflect abnormalities in the brain [ 15 ]. In addition, since it has been used as a primary outcome for the evaluation of patient emergence after anesthesia in many studies, it was used in this study as well [ 8 , 14 ].…”

“…Previous studies demonstrated that desflurane has a much lower solubility than sevoflurane and desfluraneanesthesia provides a much faster recovery profile than sevoflurane anesthesia in obese and elderly patients [10][11][12][13]. Switching sevoflurane-anesthesia to desflurane-anesthesia after endotracheal intubation also enhanced emergence and postoperative recovery in non-obese patients [14]. However, despite many studies demonstrating the impact of the longterm switch of inhalation agents, it is difficult to find previous studies investigating that of a short-term switch at the end of anesthesia.…”

Calling the patient's own name facilitates recovery from general anaesthesia: a randomised double‐blind trial

“…Eye opening is commonly used to assess a patient's responsiveness and return of consciousness during emergence from general anaesthesia . However, although patients first open their eyes when responding to a verbal command, they may be in a transitional state between consciousness and unconsciousness rather than in a fully awake state , so they commonly become unresponsive and unconscious again after first opening their eyes.…”