Effects of Chebulic Acid on Advanced Glycation Endproducts-Induced Collagen Cross-Links

Lee, Jun-Young; Oh, Jun Gu; Kim, Jin Sook; Lee, Kwang Won

doi:10.1248/bpb.b14-00034

Cited by 18 publications

(15 citation statements)

References 21 publications

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“…Plausible role of Tab.Dtox-OD (Tab.of Terminalia chebula) in Diabetes mellitus Chebulagic acid from drug Terminalia chebula is alone potent antidiabetic with its reversible and non-competitive Alpha glucosidase inhibitory effect [24] as well as antihyperlipidemic, tissue glycogen content reducing and in vitro release of insulin [25]. Many reports have alluded to the potential role of AGEs in the development of diabetic complications [26][27][28]. simultaneously the protective role of Chebulagic acid against AGEs induced endothelial cell dysfunction was also reported [29].…”

Section: Discussionmentioning

confidence: 99%

“…Chebulagic acid is a more potent inhibitor cross-linking and breaker of collagen cross-linking [30] this will unquestionably lend a hand to revolutionize the future scenario of the D.M patients on the subject of microvascular as well as macrovascular complications. Three gallotannins (3)(4)(5) from Terminalia fruits acting as enhancers of both PPARα and PPARγ signaling increased insulin stimulated glucose uptake without inducing the adipogenesis [31]. Terminalia chebula is a potential source of natural antioxidants [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

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Unique Therapeutic Approach of Tab.Dibet-All (A Poly Herbomineral Formulation), Tab.Dtox-OD and Tab.Glybra in a Newly Diagnosed Case of Type-2 Diabetes Mellitus. A Case Report

Giri¹

2018

Endocrinol Metab Syndr

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Along with all the commonly known rationale; oxidative stress, reactive oxygen species (ROS), growing number of AGEs, accumulation and outbreak of Tridoshas. Throughout year plays decisive role in the development of Diabetes as well as its complications. In the present study, I have discussed about their effective and economical management based on the principles of Ayurveda in the form of distinctive line of treatment which includes Tab.Dibet-all (a poly herbomineral formulation), Tab. Dtox-OD and Tab Glybra. This trio is indistinguishable from allopathy drugs in terms of pharmacology. With so many benefits concealed inside; this line of treatment is having remarkable potential regarding antidibetic, antiglycating, antihyperlipidimic, rejuvinative and preventive/protective activities by the means of breaking cross-links of proteins induced by AGEs, inhibition of AGE formation, blockade of the AGE-RAGE interaction, suppression of RAGE expression and prevention from glycer-AGEs-induced ROS formation ensuring good control over intricate pathology of diabetes and thus protecting diabetics to a higher extent from the complications of diabetes slowly footing towards them. This is the most imperative thing regarding intricate and vague pathology like Diabetes mellitus Only the integrated approach towards this gruesome situation will going to help mankind. May this study of 'Tab. Dibet-all (a poly herbomineral formulation), Tab. Dtox-OD and Tab. Glybra' with its sovereign effects could serve as a light of hope towards search of ideal treatment of Diabetes mellitus type-2. This can be a supplementary remedy for type-1, hereditary and chronic diabetics also and unquestionably lend a hand to revolutionize the future scenario of these tribulations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unique Therapeutic Approach of Tab.Dibet-All (A Poly Herbomineral Formulation), Tab.Dtox-OD and Tab.Glybra in a Newly Diagnosed Case of Type-2 Diabetes Mellitus. A Case Report

Giri¹

2018

Endocrinol Metab Syndr

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“…The inhibition assay was performed according to the method of Lee et al [ 21 ] with slight modifications. To confirm the inhibition of AGEs-BSA-induced cross-links to collagen by EU, 1 mg/mL of AGEs-BSA was incubated with or without AG or EU on collagen-coated 96-well plates at 37 °C for 24 h. The inhibitory ability of EU was detected using tetramethylbenzidine (TMB) as the substrate.…”

Section: Methodsmentioning

confidence: 99%

Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney

Hur

Choi

et al. 2018

Nutrients

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Eucommia ulmoides Oliv. (EU), also known as Du-Zhong, is a medicinal herb commonly used in Asia to treat hypertension and diabetes. Despite evidence of the protective effects of EU against diabetes, its precise effects and mechanisms of action against advanced glycation end-products (AGEs) are unclear. In this study, we evaluated the effects of EU on AGEs-induced renal disease and explored the possible underlying mechanisms using streptozotocin (STZ)-induced diabetic mice. STZ-induced diabetic mice received EU extract (200 mg/kg) orally for 6 weeks. EU treatment did not change blood glucose and glycated hemoglobin (HbA1c) levels in diabetic mice. However, the EU-treated group showed a significant increase in the protein expression and activity of glyoxalase 1 (Glo1), which detoxifies the AGE precursor, methylglyoxal (MGO). EU significantly upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) expression but downregulated that of receptor for AGE (RAGE). Furthermore, histological and immunohistochemical analyses of kidney tissue showed that EU reduced periodic acid–Schiff (PAS)-positive staining, AGEs, and MGO accumulation in diabetic mice. Based on these findings, we concluded that EU ameliorated the renal damage in diabetic mice by inhibiting AGEs formation and RAGE expression and reducing oxidative stress, through the Glo1 and Nrf2 pathways.

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“…The AGEs cross-link–breaking assay was performed according to the method described by Lee et al [ 40 ] with slight modifications. For the assay, 1 mg/mL peroxidase-labeled AGEs-BSA was pre-incubated on collagen-coated 96-well plates at 37 °C for 4 h. After 1 mM AG or S .…”

Section: Methodsmentioning

confidence: 99%

Spatholobus suberectus Ameliorates Diabetes-Induced Renal Damage by Suppressing Advanced Glycation End Products in db/db Mice

Hur

Choi

et al. 2018

IJMS

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Spatholobus suberectus (SS) is a medicinal herb commonly used in Asia to treat anemia, menoxenia and rheumatism. However, its effect of diabetes-induced renal damage and mechanisms of action against advanced glycation end-products (AGEs) are unclear. In this study, we evaluated the effects of SS on diabetes-induced renal damage and explored the possible underlying mechanisms using db/db type 2 diabetes mice. db/db mice were administered SS extract (50 mg/kg) orally for 6 weeks. SS-treated group did not change body weight, blood glucose and glycated hemoglobin (HbA1c) levels. However, SS treatment reversed diabetes-induced dyslipidemia and urinary albumin/creatinine ratio in db/db mice. Moreover, SS administration showed significantly increased protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), which is a transcription factor for antioxidant enzyme. SS significantly upregulated glyoxalase 1 (Glo1) and NADPH quinine oxidoreductase 1 (NQO1) expression but reduced CML accumulation and downregulated receptor for AGEs (RAGE). Furthermore, SS showed significant decrease of periodic acid–Schiff (PAS)-positive staining and AGEs accumulation in histological and immunohistochemical analyses of kidney tissues. Taken together, we concluded that SS ameliorated the renal damage by inhibiting diabetes-induced glucotoxicity, dyslipidemia and oxidative stress, through the Nrf2/antioxidant responsive element (ARE) stress-response system.

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Effects of Chebulic Acid on Advanced Glycation Endproducts-Induced Collagen Cross-Links

Cited by 18 publications

References 21 publications

Unique Therapeutic Approach of Tab.Dibet-All (A Poly Herbomineral Formulation), Tab.Dtox-OD and Tab.Glybra in a Newly Diagnosed Case of Type-2 Diabetes Mellitus. A Case Report

Unique Therapeutic Approach of Tab.Dibet-All (A Poly Herbomineral Formulation), Tab.Dtox-OD and Tab.Glybra in a Newly Diagnosed Case of Type-2 Diabetes Mellitus. A Case Report

Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney

Spatholobus suberectus Ameliorates Diabetes-Induced Renal Damage by Suppressing Advanced Glycation End Products in db/db Mice

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