Effects of chelated Zn/Cu/Mn on redox status, immune responses and hoof health in lactating Holstein cows

Abstract

To evaluate the effects of chelated Zn/Cu/Mn on redox status, immune responses and hoof health in lactating Holstein cows, 48 head in early lactation were divided into healthy or lame groups according to their gait score. Cows were fed the same amount of Zn/Cu/Mn as sulfate salts or in chelated forms for 180 days, and foot-and-mouth disease (FMD) vaccine was injected at day 90. The results showed that lame cows had lower antioxidant function, serum Zn/Mn levels, hair Cu levels, and hoof hardness. Moreover, increased antioxidant status, FMD antibody titers, serum and hair levels of Zn/Cu/Mn, and hoof hardness and decreased milk fat percent and arthritis biomarkers were observed in cows fed chelated Zn/Cu/Mn. In summary, supplementation with chelated Zn/Cu/Mn improved antioxidant status and immune responses, reduced arthritis biomarkers, and increased accumulation of Zn/Cu/Mn in the body and hoof hardness in dairy cows.

Corium molecular biomarkers reveal a beneficial effect on hoof transcriptomics in peripartal dairy cows supplemented with zinc, manganese, and copper from amino acid complexes and cobalt from cobalt glucoheptonate

“…The changes in expression of oxidative stress-related genes at the level of hoof tissue agree with the systemic biomarkers measured in these cows (Batistel et al, 2016). Clearly, these systemic and local events could increase the susceptibility of the cows to develop lameness (Zhao et al, 2015a). More research is needed to determine the extent to which oxidative stress plays a role in lameness and how dietary trace minerals help prevent it.…”

IGF1 Knockdown Hinders Myocardial Development through Energy Metabolism Dysfunction Caused by ROS-Dependent FOXO Activation in the Chicken Heart

“…iNOS is an oxidative stress (free radical) that utilizes nitric oxide, which can be produced when cells are stimulated and activated. The cells can form a complex antioxidant enzyme defense system, which mainly includes SOD, CAT, GSH, and so on, to protect the body from peroxidative damage [26,31]. SOD can eliminate free radicals in the body and protect cells from free radical damage.…”

Biodisponibilidad de minerales que lados y no que lados: una revisión sistemática

“…Como resultado, hubo aumento de la fagocitosis, concentración de Cu en la leche y mayor respuesta inmunológica en el grupo que suplementó los minerales en la forma quelada. En coincidencia con estos resultados Zhao et al 18 , suplementando los mismos minerales en vacas, demostraron la mayor biodisponibilidad de los MQ a través de una mejor actividad de las enzimas antioxidantes: glutatión reducida, superóxido dismutasa, glutatión peroxidasa y metalotioneína; mayor concentración sérica de los minerales, mejora del sistema inmunológico y síntesis de queratina.…”