Effects of Chemical and Heat Treatments on Surface Characteristics and Biocompatibility of Titanium-Niobium Alloys

Abstract

Alkali solution-and heat-treatments were employed to modify the surfaces of Ti-6Al-4V, Ti-40Nb-1Hf and Ti-30Nb-1Fe-1Hf alloys, and then the surface characteristics and the biocompatibility of the treated alloys were analyzed. The formation of porous surfaces that contain numerous nano-pores and irregular cracks, together with the increase in hydroxyl, TiO 2 and Nb 2 O 5 contents in the surface layer of the treated Ti40Nb-1Hf and Ti-30Nb-1Fe-1Hf alloys, have been found to enhance biocompatibility which was evaluated by the osteoblast cell culture in vitro. In addition, the biocompatibility of both Ti-40Nb-1Hf and Ti-30Nb-1Fe-1Hf alloys are comparable to that of Ti-6Al-4V alloy. Alkali solutionand heat-treatments are believed to enhance bone-bonding ability of both Ti-40Nb-1Hf and Ti-30Nb-1Fe-1Hf alloys, and therefore are useful for surface modification practice.

Surface Modification of Titanium and its Alloys for the Enhancement of Osseointegration in Orthopaedics

“…The biocompatibility of the treated surfaces was evaluated through cell studies. The results ensured that the biocompatibility and bone bonding were improved after the alkali-heat treatment compared with the untreated samples 59 . Lee et al 60 inserted the alkali-heat treated and untreated pure Ti, Ti-6Al-4V alloy implants in the mice.…”

Effect of Nb addition on anodic behavior of Ti alloy in electrolyte containing calcium and phosphorus

“…8(d)) shows that the binding energy of Ca 2+ 2p3/2 and Ca 2+ 2p1/2 peaks appeared at 347.8 and 351.4 eV, respectively. The P 2p XPS spectrum shows that the peaks at 133.8 eV and 134.6 eV can be identified as HPO 4 2− (Fig. 8(e)).…”

“…7(d) shows the P XPS spectrum. In the P 2p spectrum, the peaks at 133.8 eV and 134.6 eV are mainly associated with P 5+ (HPO 4 2 − ).…”

“…This Ti-30Nb-1Fe-1Hf alloy has relatively high strength and low elastic modulus (UTS: 914 MPa, 0.2% proof stress: 862 MPa and E: 62 GPa) [2]. In addition, surface modification techniques, such as plasma treating [3], alkali treatment [4], sol-gel processes [5], plasma spray [6] and anodic oxidation [7], are generally applied to Ti implants to improve their biological performance. For example, anodic oxidation on Ti implants in the Ca-and P-containing electrolyte has been shown to effectively improve bone response in vivo [8,9] and in vitro [10,11].…”

http://www.omicsgroup.org/journals/polyolefin-from-commodity-to-specialty-2169-0022-1000e111.php?aid=47818

“…Ti-6Al-4V (Ti64) has been use for biomaterials due to its good biocompatibility [1][2][3]. Therefore, the combination use with the conventional stainless steel of SUS316L (SUS) is increasing due to accidental misuse in emergency cases or necessary choice of stainless wire to tie up bone fragments in complicated fracture and femoral mid shaft fracture after Total Hip Arthroplasty.…”