Effects of chemical forms of gadolinium on the spleen in mice after single intravenous administration

Nakamura, Ryosuke; Takanezawa, Yasukazu; Ohshiro, Yuka; Uraguchi, Shimpei; Kiyono, Masako

doi:10.1016/j.bbrep.2022.101217

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…The level was highest for gadodiamide [ 62 ]. In mice, high doses were found in the kidneys after high-dose gadodiamide (7.49 nmol/g tissue) or gadobutrol (16.36 nmol/g tissue) administration, but no spleen enlargement was found after GBCA administration [ 63 ]. In subtotally nephrectomised rats, higher Gd levels 28 days after administration of gadobutrol or gadoterate versus gadoteridol were determined in the kidneys and liver.…”

Section: Introductionmentioning

confidence: 99%

Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward

van der Molen,

Quattrocchi,

Mallio

et al. 2023

Eur Radiol

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In 2014, for the first time, visible hyperintensities on unenhanced T1-weighted images in the nucleus dentatus and globus pallidus of the brain were associated with previous Gadolinium-based contrast agent (GBCA) injections and gadolinium deposition in patients with normal renal function. This led to a frenzy of retrospective studies with varying methodologies that the European Society of Magnetic Resonance in Medicine and Biology Gadolinium Research and Educational Committee (ESMRMB-GREC) summarised in 2019. Now, after 10 years, the members of the ESMRMB-GREC look backward and forward and review the current state of knowledge of gadolinium retention and deposition. Clinical relevance statement Gadolinium deposition is associated with the use of linear GBCA but no clinical symptoms have been associated with gadolinium deposition. Key Points • Traces of Gadolinium-based contrast agent-derived gadolinium can be retained in multiple organs for a prolonged time. • Gadolinium deposition is associated with the use of linear Gadolinium-based contrast agents. • No clinical symptoms have been associated with gadolinium deposition.

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Section: Introductionmentioning

confidence: 99%

Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward

van der Molen,

Quattrocchi,

Mallio

et al. 2023

Eur Radiol

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“…Nowadays, only small gadolinium-based organic molecules have been FDA-approved as positive contrast agents for nanomedicine . However, they suffer from several disadvantages, like potential biotoxicity, fast clearance from the body and thus short circulation times, as well as undesired accumulation of gadolinium ions in human tissues . To overcome these drawbacks, it is possible to incorporate paramagnetic ions inside size-tunable nanoparticles, exhibiting lower toxicity and increased retention within the body …”

Section: Resultsmentioning

confidence: 99%

From Nanothermometry to Bioimaging: Lanthanide-Activated KY₃F₁₀ Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine

Cressoni

Vurro

Milan

et al. 2023

ACS Appl. Mater. Interfaces

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Lanthanide-activated fluoride-based nanostructures are extremely interesting multifunctional tools for many modern applications in nanomedicine, e.g., bioimaging, sensing, drug delivery, and photodynamic therapy. Importantly, environmental-friendly preparations using a green chemistry approach, as hydrothermal synthesis route, are nowadays highly desirable to obtain colloidal nanoparticles, directly dispersible in hydrophilic media, as physiological solution. The nanomaterials under investigation are new KY 3 F 10 -based citrate-capped core@shell nanostructures activated with several lanthanide ions, namely, Er 3+ , Yb 3+ , Nd 3+ , and Gd 3+ , prepared as colloidal water dispersions. A new facile microwaveassisted synthesis has been exploited for their preparation, with significant reduction of the reaction times and a fine control of the nanoparticle size. These core@shell multifunctional architectures have been investigated for use as biocompatible and efficient contrast agents for optical, magnetic resonance imaging (MRI) and computerized tomography (CT) techniques. These multifunctional nanostructures are also efficient noninvasive optical nanothermometers. In fact, the lanthanide emission intensities have shown a relevant relative variation as a function of the temperature, in the visible and near-infrared optical ranges, efficiently exploiting ratiometric intensity methods for optical thermometry. Importantly, in contrast with other fluoride hosts, chemical dissolution of KY 3 F 10 citrate-capped nanocrystals in aqueous environment is very limited, of paramount importance for applications in biological fluids. Furthermore, due to the strong paramagnetic properties of lanthanides (e.g., Gd 3+ ), and X-ray absorption of both yttrium and lanthanides, the nanostructures under investigation are extremely useful for MRI and CT imaging. Biocompatibility studies of the nanomaterials have revealed very low cytotoxicity in dfferent human cell lines. All these features point to a successful use of these fluoride-based core@shell nanoarchitectures for simultaneous diagnostics and temperature sensing, ensuring an excellent biocompatibility.

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“…Nakamura et al, 2022 [29] BALB/c male mice treated with a single administration of Omniscan™ (gadodiamide), Gadovist ® (gadobutrol), or Gd (III) in the form of Gd(NO 3 ) 3 or GdCl 3…”

Section: Reference Study Design Main Findingsmentioning

confidence: 99%

“…Other plausible mechanisms underlying Gd (III) toxicity include blockage of adenosine diphosphate and adenosine triphosphate (ATP) hydrolysis through stimulation of angiotensin II AT1 receptors [78]; inhibition of ATP-permeable channels [106]; interference with the epithelial Na + -channel's activity [63]; downregulation of RhoA, mTORC1, and mTORC2 proteins [31]; and inhibition on both inward and outward ionic current through Gd (III) accumulation at the binding site of the Na + -Ca 2+ exchanger protein that carries the current [104]. It may also interfere with the mobilization of iron [29,67], as it has been associated with total iron-binding capacity (TIBC) decrease [75], and to increases in serum iron, ferritin [41,75,80], and transferrin saturation [75]. It also has an effect on the differentiation of mononuclear cells into ferroportin-expressing fibrocytic cells [67] and the differentiation of mononuclear cells into collagen-secreting cells, with increased expression of iron metabolism proteins and of angiogenic and osteoblast-lineage markers [73].…”

Section: Reference Study Design Main Findingsmentioning

confidence: 99%

Toxicity Mechanisms of Gadolinium and Gadolinium-Based Contrast Agents—A Review

Coimbra,

Rocha,

Sousa

et al. 2024

IJMS

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Gadolinium-based contrast agents (GBCAs) have been used for more than 30 years to improve magnetic resonance imaging, a crucial tool for medical diagnosis and treatment monitoring across multiple clinical settings. Studies have shown that exposure to GBCAs is associated with gadolinium release and tissue deposition that may cause short- and long-term toxicity in several organs, including the kidney, the main excretion organ of most GBCAs. Considering the increasing prevalence of chronic kidney disease worldwide and that most of the complications following GBCA exposure are associated with renal dysfunction, the mechanisms underlying GBCA toxicity, especially renal toxicity, are particularly important. A better understanding of the gadolinium mechanisms of toxicity may contribute to clarify the safety and/or potential risks associated with the use of GBCAs. In this work, a review of the recent literature concerning gadolinium and GBCA mechanisms of toxicity was performed.

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Effects of chemical forms of gadolinium on the spleen in mice after single intravenous administration

Cited by 7 publications

References 26 publications

Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward

Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward

From Nanothermometry to Bioimaging: Lanthanide-Activated KY₃F₁₀ Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine

Toxicity Mechanisms of Gadolinium and Gadolinium-Based Contrast Agents—A Review

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Effects of chemical forms of gadolinium on the spleen in mice after single intravenous administration

Cited by 7 publications

References 26 publications

Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward

Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward

From Nanothermometry to Bioimaging: Lanthanide-Activated KY3F10 Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine

Toxicity Mechanisms of Gadolinium and Gadolinium-Based Contrast Agents—A Review

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From Nanothermometry to Bioimaging: Lanthanide-Activated KY₃F₁₀ Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine