Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity

Pijnenburg, Annick; Honig, Wiel; Heyden, J.A.M. van der; Rossum, J. M. van

doi:10.1016/0014-2999(76)90299-5

Cited by 547 publications

(144 citation statements)

References 31 publications

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“…Since DA release in the ventral striatum is well known to be involved in psychostimulant-induced hyperlocomotion (Pijnenburg et al, 1976), we used microdialysis to sample DA levels in the ventral striatum and compared these to WT and KO responses in the home cage and OF. RMANOVA for within-subjects effects demonstrated a significant effect of time (F(4,44) ¼ 4.430, po0.004), but no significant time by genotype interaction.…”

Section: Brain Monoaminesmentioning

confidence: 99%

Novelty Seeking and Stereotypic Activation of Behavior in Mice with Disruption of the Dat1 Gene

Pogorelov

Rodriguiz

Insco

et al. 2005

Neuropsychopharmacol

137

116

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Disruption of the dopamine (DA) transporter (Dat1) gene in mice leads to a 50% reduction or complete elimination of Dat1 expression in striatum of respective heterozygous (HZ) and knockout (KO) mice. Compared to wild-type (WT) controls, extracellular DA is increased approximately two-and five-fold in the mutants. Although open field (OF) activity is similar for WT and HZ animals, it is enhanced for KO mice. The purpose of the present investigations was to study spontaneously emitted behaviors and to determine the behavioral and neurochemical mechanisms that may contribute to the hyperactivity of KO animals. Heterozygotes are less anxious than other genotypes and they engage in novelty-seeking behaviors that include increased time spent in the center of the OF, enhanced investigation of objects, and augmented free exploration of a novel environment. By comparison, KO mice display neophobia when initially exposed to novel conditions. Over time the anxiety-like response habituates and behaviors become activated and stereotyped; these responses are unrelated to exploration or novelty seeking. No alterations in extracellular DA levels or tissue contents from several brain regions are detected at the time of stereotypic activation of KO mice. By contrast, this behavior is accompanied by changes in serotonin metabolism in basal ganglia. This feature may contribute to the behavioral inflexibility of KO mice in different experimental contexts. Collectively, these findings suggest that disruption of the Dat1 gene in mice leads to two different phenotypes; one related to anxiety-reducing and novelty seeking, while the other has some homology to disorders with a stereotypical-perseverative spectrum.

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Section: Brain Monoaminesmentioning

confidence: 99%

Novelty Seeking and Stereotypic Activation of Behavior in Mice with Disruption of the Dat1 Gene

Pogorelov

Rodriguiz

Insco

et al. 2005

Neuropsychopharmacol

137

116

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“…The nucleus accumbens has been receiving increased attention, partly because of evidence implicating the mesolimbic dopamine projections to the nucleus accumbens in the control of motor activity (Pijnenburg et al, 1976;Kelly et al, 1975;Costall and Naylor, 1975). Injections of dopamine, L-DOPA, amphetamine or apomorphine into the nucleus accumbens stimulate locomotor activity in laboratory animals (Andrn and Jackson, 1975;Costall et al, 1976;1980;Pijnenburg et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

“…Injections of dopamine, L-DOPA, amphetamine or apomorphine into the nucleus accumbens stimulate locomotor activity in laboratory animals (Andrn and Jackson, 1975;Costall et al, 1976;1980;Pijnenburg et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

The hypomotility elicited by small doses of apomorphine seems exclusively mediated by dopaminergic systems in the nucleus accumbens

Radhakishun

Ree

1987

European Journal of Pharmacology

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The reduction of motor activity elicited in rats by a subcutaneous injection of a small dose of apomorphine was reversed by pretreatment of the nucleus accumbens with haloperidol (10 pg), sulpiride (10 pg) or desenkephalin--f-endorphin (DE),E) (100 pg or 10 ng). These doses of the compounds did not change motor activity in placebo-treated rats. Pretreatment of the nucleus caudatus with the same neuroleptics or DE'rE did not diminish the effect of subcutaneously administered low doses of apomorphine. A small dose of apomorphine decreased motor activity when it was injected directly into the nucleus accumbens. This effect was dose dependently antagonized by subcutaneous pretreatment with DE~,E. It is suggested that the hypoactivity elicited by small doses of apomorphine is exclusively mediated by dopaminergic systems in the nucleus accumbens.

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“…This suggests that DA in NAc mediates hyperlocomotion, whereas DA in the dorsal striatum mediates stereotypies. In fact selective injections of amphetamine within the NAc [103] as well as in the ventrolateral striatum [104] induce hyper-locomotion, whereas injections in the dorsal striatum produce stereotypies [104-106]. …”

Section: Methamphetamine-induced Behavioural Effectsmentioning

confidence: 99%

The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity

Ferrucci

Giorgi

Bartalucci

et al. 2013

Current Neuropharmacology

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The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focuses on the modulation exerted by central NE pathways on the behavioural and neurotoxic effects produced by the psychostimulant methamphetamine, essentially the modulation of the activity of mesencephalic dopamine (DA) neurons. In fact, although NE in itself mediates some behavioural effects induced by methamphetamine, NE modulation of DA release is pivotal for methamphetamine-induced behavioural states and neurotoxicity. These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters.

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Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity

Cited by 547 publications

References 31 publications

Novelty Seeking and Stereotypic Activation of Behavior in Mice with Disruption of the Dat1 Gene

Novelty Seeking and Stereotypic Activation of Behavior in Mice with Disruption of the Dat1 Gene

The hypomotility elicited by small doses of apomorphine seems exclusively mediated by dopaminergic systems in the nucleus accumbens

The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity

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