A mass of aberrant tissue that has grown as a result of excessive, autonomous, and uncontrolled cell proliferation is known as a cancer, neoplasm, or tumour. The loss of the cell's regulatory system and an aberrant chromosome or DNA mutation are both contributing factors to this condition. Neoplasm refers to new growth, and neoplasia refers to the process of cell proliferation. Oncology, which derives from the Greek words oncos, which means tumour, and logos, which means study, is the area of medicine that deals with the thorough examination of a neoplasm (tumour), as well as its growth, diagnosis, and treatment. Generally, all malignant tumours are referred to as cancer. A safe and effective alternative for the treatment of tumours that produce granular exocytosis (perforin and granzymes) and death and do not respond to conventional treatment, cancer immunotherapy has emerged in recent years as two primary pathways implicated in CL-mediated tumour cell death. Treatments, including various ligand kinds, are briefly discussed before a comprehensive analysis of high aggressiveness. New immune modulators include immunotherapy, CTLA-4 blockers (cytotoxic T-lymphocytes unsupervised), and drugs involved in cell death during immunological cancer. Due to metastases from neighbouring organs and coexisting conditions such cirrhosis and chronic hepatitis, primary liver cancer is challenging to precisely diagnose after death. By altering the base rate or by influencing risk modification by sex and age, trends in diagnostic accuracy may have an impact on estimates of the radiation risk for liver cancer.