Effects of Chenopodium album Linne on Gastritis and Gastric Cancer Cell Growth

Kim, Pitna; Jeong, Choon Sik

doi:10.4062/biomolther.2011.19.4.487

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…28,29 Fasted ICR mice were orally treated with HAD-B (200 mg/kg) or ranitidine (40 mg/kg) for 3 times (twice/day). Thirty minutes later after the last administration, 400 lL of 60% ethanol in 150 mM HCl was administered orally.…”

Section: Etoh/hcl-induced Gastritismentioning

confidence: 99%

HangAmDan-B, an Ethnomedicinal Herbal Mixture, Suppresses Inflammatory Responses by Inhibiting Syk/NF-κB and JNK/ATF-2 Pathways

Moh

Kim

et al. 2013

Journal of Medicinal Food

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HangAmDan-B (HAD-B) is a powdered mixture of eight ethnopharmacologically characterized folk medicines that is prescribed for solid masses and cancers in Korea. In view of the finding that macrophage-mediated inflammation is a pathophysiologically important phenomenon, we investigated whether HAD-B modulates inflammatory responses and explored the associated molecular mechanisms. The immunomodulatory activity of HAD-B in toll-like receptor-activated macrophages induced by lipopolysaccharide (LPS) was assessed by measuring nitric oxide (NO) and prostaglandin E2 (PGE2) levels. To identify the specific transcription factors (such as nuclear factor [NF]-jB and signaling enzymes) targeted by HAD-B, biochemical approaches, including kinase assays and immunoblot analysis, were additionally employed. HAD-B suppressed the production of PGE2 and NO in LPS-activated macrophages in a dose-dependent manner. Furthermore, the extract ameliorated HCl/EtOH-induced gastritis symptoms. Moreover, HAD-B significantly inhibited LPS-induced mRNA expression of inducible NO synthase and cyclooxygenase (COX)-2. Interestingly, marked inhibition of NF-jB and activating transcription factor was observed in the presence of HAD-B. Data from direct kinase assays and immunoblot analysis showed that HAD-B suppresses activation of the upstream signaling cascade involving spleen tyrosine kinase, Src, p38, c-Jun N-terminal kinase, and transforming growth factor b-activated kinase 1. Finally, kaempferol, but not quercetin or resveratrol was identified as a bioactive compound in HAD-B. Therefore, our results suggest that HAD-B possesses anti-inflammatory activity that contributes to its anticancer property.

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Section: Etoh/hcl-induced Gastritismentioning

confidence: 99%

HangAmDan-B, an Ethnomedicinal Herbal Mixture, Suppresses Inflammatory Responses by Inhibiting Syk/NF-κB and JNK/ATF-2 Pathways

Moh

Kim

et al. 2013

Journal of Medicinal Food

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Effects of dietary supplementation with fermented Chenopodium album L. on growth, nutrient digestibility, immunity, carcase characteristics and meat quality of broilers

Xie

Wang

et al. 2021

Italian Journal of Animal Science

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Modulation of the pharmacokinetics, therapeutic and adverse effects of NSAIDs by Chinese herbal medicines

Fong

Efferth

Zuo

2014

Expert Opinion on Drug Metabolism & Toxicology

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While majority of CHMs demonstrated effectiveness in alleviating NSAIDs-induced adverse effects and potentiating the therapeutic effects, this review provides insights for development of CHMs as add-on medications to NSAIDs therapies. However, since limited information was from well-designed clinical trials, the findings are not yet conclusive and more clinical studies are warranted to provide guidance for healthcare professionals. In future, researches on interactions between NSAIDs and CHMs are expected to grow and modern approaches such as pharmacogenomics might enhance the throughput and accuracy of identifying clinically relevant interactions.

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Effects of Chenopodium album Linne on Gastritis and Gastric Cancer Cell Growth

Cited by 3 publications

References 22 publications

HangAmDan-B, an Ethnomedicinal Herbal Mixture, Suppresses Inflammatory Responses by Inhibiting Syk/NF-κB and JNK/ATF-2 Pathways

HangAmDan-B, an Ethnomedicinal Herbal Mixture, Suppresses Inflammatory Responses by Inhibiting Syk/NF-κB and JNK/ATF-2 Pathways

Effects of dietary supplementation with fermented Chenopodium album L. on growth, nutrient digestibility, immunity, carcase characteristics and meat quality of broilers

Modulation of the pharmacokinetics, therapeutic and adverse effects of NSAIDs by Chinese herbal medicines

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