Effects of Chichorium intybus on bilirubin

Hossain, Nassirian; Eslami, Saeedeh Tarvij

doi:10.1007/s12098-008-0033-6

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…In another study by Nassirian and Eslami the effect of chicory on neonatal jaundice was found to be insignificant (30). The effects of three traditional treatments (i.e., camel's thorn, flixweed, and sugar water) were evaluated at Ghaem Hospital in Mashhad, Iran, between 2005 and 2009 on 336 neonates.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Natural Products on Jaundice in Iranian Neonates

Fakhri

Farhadi

Mousavinasab

et al. 2019

Jundishapur J Nat Pharm Prod

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Context: Neonatal jaundice is the most common clinical problem in preterm and term neonates, and phototherapy is the most frequent treatment method for this condition. Researchers have long held that the use of natural products, especially medicinal plants, can reduce the incidence of neonatal jaundice, and in turn, the use of phototherapy in the treatment of neonatal jaundice in some countries including Iran. Objective: We aimed to carry out a systematic review on the effects of natural products on jaundice in Iranian neonates. Data Sources: Articles evaluating the effect of natural products on jaundice in Iranian neonates until the end of 2017 were searched using Google Scholar and IranMedex, SID, Magiran, IranDoc, Medlib, ScienceDirect, PubMed, Scopus, Cochrane, Embase, Web of Science, and Medline databases. Study Selection: Studies evaluating the effect of natural products on neonatal jaundice were included in the study. Studies were selected from the databases by screening titles, keywords and abstracts. Hence, all the articles which had the keywords in their titles, keywords or abstracts were selected. The inclusion criteria included: carrying out the study in Iran, being performed on neonates and using a natural product (herbal or non-herbal) to reduce neonatal jaundice. The articles that did not meet these criteria were excluded. Data Extraction: The ideal reporting items for systematic review and meta-analysis (PRISMA) checklist was used to evaluate the quality of the articles. Finally, a checklist was designed by the researchers to collect the data. The items of the checklist were the name of the first author of article, study objective, study setting, age, weight, number and gender of the neonates included, name, dose and frequency of the use of the natural product, route of delivery, and method of using the natural product (such as oral/nonoral). Results: The number of neonates enrolled in the 21 included studies was 2237. The effect of natural products on preventing neonatal jaundice was not statistically significant, but in some studies, the use of natural products in combination with phototherapy was found to be effective in the treatment of neonatal jaundice. Conclusions: The use of natural products for the prevention and treatment of neonatal jaundice requires further studies, but the usage of natural products such as medicinal plants like Cotoneaster with phototherapy could be possibly effective in reducing the duration of phototherapy and hospitalization.

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Section: Resultsmentioning

confidence: 99%

“…In the studies of Nassirian and Eslami (30) and Nabavizadeh et al (40), the effect of natural products on neonatal blood parameters was measured. Also, in studies performed using barley flour, barley flour was sprayed on the entire body of the neonates other than the face and cord (39).…”

Section: Discussionmentioning

confidence: 99%

Effect of Natural Products on Jaundice in Iranian Neonates

Fakhri

Farhadi

Mousavinasab

et al. 2019

Jundishapur J Nat Pharm Prod

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“…In agreement with the results of this study, Nassirian et al examined the effect of chicory essence on neonatal hyperbilirubinemia among 30 infants and reported that the differences in direct and indirect bilirubin levels were not significant in any of the groups. In addition, no significant difference was observed in the examination of term and preterm infants (15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Effect of Common Chicory Essence and Phototherapy on Serum Bilirubin Levels in Preterm Infants Admitted to Neonatal Intensive Care Unit: An In Vitro Study

et al. 2022

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: Jaundice is a common neonatal disorder that occurs in most term and preterm infants. Chicory or dandelion flower has long been used in the treatment of jaundice. This study aimed to investigate the effect of common chicory essence and phototherapy on serum bilirubin levels in preterm infants admitted to the neonatal intensive care unit (NICU) of Valiasr Hospital in Birjand, Iran. This in vitro study was conducted on preterm infants with gestational age of less than 37 weeks and weight less than 2500 g. Bilirubin levels in blood samples from 21 infants were measured before and after the addition of chicory essence or distilled water. Then, phototherapy was performed, and bilirubin levels were measured again. Data were analyzed using SPSS (version 21). The mean weight of infants was 1542.8 ± 453.5 g. In the chicory essence group, the mean total serum bilirubin was 5.29 ± 1.55 and 0.18 ± 0.07 mg/dL before and after the intervention, respectively (P < 0.001). The mean indirect serum bilirubin was 4.96 ± 1.59 and 0.18 ± 0.07 mg/dL before and after the intervention, respectively (P < 0.001). The mean changes in total bilirubin in the distilled water and chicory groups were 5.15 ± 1.70 and 5.43 ± 1.99 mg/dL, respectively (P = 0.62). The results showed that both distilled water and chicory essence decreased direct and total serum bilirubin concentrations. The indirect bilirubin changes were not significant, and there was no difference in the total bilirubin changes between the two groups. Totally, the chicory essence had no effect on reducing the serum bilirubin level in preterm infants.

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