Effects of Chicken MHC Haplotype on Resistance to Distantly Related Infectious Bronchitis Viruses

The Chicken MHC: Insights into Genetic Resistance, Immunity, and Inflammation Following Infectious Bronchitis Virus Infections

“…Using UCD 331 (B2) and UCD 335 (B19) as an IBV resistant-susceptible pair of animal models, studies were performed to better understand the mechanism underlying genetic resistance to IBV [12,47]. In an attempt to elucidate the role of innate immune responses in resistant and susceptible birds challenged with two IBV genotypes, RNA sequencing was performed to assess gene expression in tracheas of B2 and B19 chickens [47].…”

“…Using UCD 331 (B2) and UCD 335 (B19) as an IBV resistant-susceptible pair of animal models, studies were performed to better understand the mechanism underlying genetic resistance to IBV [12,47]. In an attempt to elucidate the role of innate immune responses in resistant and susceptible birds challenged with two IBV genotypes, RNA sequencing was performed to assess gene expression in tracheas of B2 and B19 chickens [47]. The susceptible B19 line showed a high expression of genes related to inflammation and innate immunity, which potentially explains the more severe clinical signs and tracheal lesions in B19 compared with B2 [12,47].…”

“…To study disease resistance in chickens, MHC congenic chicken lines that share the same genetic background with differences exclusively in their MHC B locus have been developed [20][21][22][23]. Using these chicken lines as animal models, associations between MHC haplotypes and disease resistance or susceptibility have been described for several infectious pathogens, including coccidia [24,25], pathogenic bacteria [26][27][28][29], oncogenic viruses [30][31][32][33][34][35][36][37], and other viruses including IBV [38][39][40][41][42][43][44][45][46][47]. The main focus of the present review is IBV.…”

“…With some diseases, such as infectious bronchitis, high serum antibody levels elicited by vaccination do not necessarily correspond to protection [46,49,50]. Studying the genetic resistance to IBV determined by the chicken MHC is essential to better understand the mechanisms underlying resistance and, consequently, to use this knowledge to improve IBV prevention [6,9,12,39,42,44,46,47].…”

Host Antiviral Responses against Avian Infectious Bronchitis Virus (IBV): Focus on Innate Immunity

“…However, due to error-prone viral genome replication and poor cross-protection among IBV strains of different serotypes, current vaccines are inadequate to offer full protection [ 12 ]. Furthermore, the importance of chicken breed in IBV resistance was also discussed [ 2 ], and the MHC B locus was known to play a crucial role in susceptibility to the virus [ 13 ]. Detrimental local inflammatory responses in certain chicken breeds, for instance, 335/B19, might be associated with susceptibility to IBV [ 14 ].…”