Effects of childhood adversity trajectories on mental health outcomes in late adolescence: The buffering role of parenting practices in Taiwan

Lee, Miaw Chwen; Huang, Nicole; Chen, Chuan Yu

doi:10.1016/j.chiabu.2020.104705

Cited by 11 publications

(10 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In childhood and adolescence, ELS is not only associated with the heightened risk of adverse health problems [26][27][28][29][30][31][32], including physical illnesses such as headache [33] and asthma [34] but also mental illnesses such as depression, non-suicidal self-injury (NSSI) [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. A meta-analysis that examined the association between ELS and depression in adolescents found that the association between childhood abuse/neglect and depression was much stronger in adolescents than in adults [50].…”

Section: Introductionmentioning

confidence: 99%

Dissecting early life stress-induced adolescent depression through epigenomic approach

Ochi

Dwivedi

2022

Mol Psychiatry

View full text Add to dashboard Cite

Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric disorders in later life. Previous studies have suggested that ELS can cause profound changes in gene expression through epigenetic mechanisms, which can lead to psychiatric disorders in adulthood; however, studies on epigenetic modifications associated with ELS and psychiatric disorders in adolescents are limited. Moreover, how these epigenetic modifications can lead to psychiatric disorders in adolescents is not fully understood. Commonly, DNA methylation, histone modification, and the regulation of noncoding RNAs have been attributed to the reprogramming of epigenetic profiling associated with ELS. Although only a few studies have attempted to examine epigenetic modifications in adolescents with ELS, existing evidence suggests that there are commonalities and differences in epigenetic profiling between adolescents and adults. In addition, epigenetic modifications are sex-dependent and are influenced by the type of ELS. In this review, we have critically evaluated the current evidence on epigenetic modifications in adolescents with ELS, particularly DNA methylation and the expression of microRNAs in both preclinical models and humans. We have also clarified the impact of ELS on psychiatric disorders in adolescents to predict the development of neuropsychiatric disorders and to prevent and recover these disorders through personalized medicine.

show abstract

Section: Introductionmentioning

confidence: 99%

Dissecting early life stress-induced adolescent depression through epigenomic approach

Ochi

Dwivedi

2022

Mol Psychiatry

View full text Add to dashboard Cite

show abstract

“…Interventions to reduce stress may help decrease the risk of MDD. Additionally, positive parenting practices and peer social support can provide potentially valuable resilience strategies [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients

Tao

Zhang

et al. 2022

BMC Psychiatry

View full text Add to dashboard Cite

Objective We aimed to investigate the effect of differentially methylated genes and chronic childhood stress on the development of depressive symptoms in Chinese adolescents, as well as to test whether methylation at baseline can be used as a predictor of remission at follow-up after six weeks of treatment. Methods After recruiting 87 MDD patients and 53 healthy controls, we compared demographic and baseline clinical characteristics. The Childhood Chronic Stress Questionnaire was used to assess stress caused by early-life events. MDD patients underwent six weeks of treatment, and response to treatment was assessed using the Beck Depression Inventory-II. In addition, four MDD patients and five controls were randomly chosen for genome-wide methylation analysis. Results The gene RPS6KA5 showed significant methylation differences between the two groups. Severity of chronic childhood stress was significantly associated with increased risk of depression in adolescents, but not with treatment response. Baseline RPS6KA5 methylation can predict remission after six weeks of treatment. We did not observe any interaction between RPS6KA5 methylation and chronic childhood stress. Conclusions Our results suggest that RPS6KA5 methylation can be used as a predictor of response to treatment in adolescent MDD patients. Here we offer new evidence for the role of epigenetics in early response to treatment of depression. Trial registration ChiCTR, ChiCTR2000033402, 31/05/2020, http://www.chictr.org.cn/index.aspx

show abstract

“…We performed a systematic review that focused on the relationship between childhood adversities, such as parental divorce, parental death, parental substance abuse, parental hospitalization, parental criminality, residential instability, household living on public assistance, and parental migration (left behind children). 10 The outcome was mental health based on the WHO ICD 10 classification of Mental and Behavioral Disorders, depression, anxiety disorder, stress, suicide, and behavioral disorder due to alcohol, drugs, and smoking. However, it does not limit it to other mental health disorders.…”

Section: Methodsmentioning

confidence: 99%

“… 9 Children feel loss of support, loss of affection, decrease in cognitive stimulation, also social interaction is disrupted. 10 Parents with these conditions also tend to be frustrated and uncontrolled, so the role of parents cannot be maximized. 11 Further, it also leads to childhood adversities (CA).…”

Section: Introductionmentioning

confidence: 99%

“…13 Several studies regarding the relationship between childhood adversities and mental health have been published and well-documented. 10,[14][15][16] There was one study related to the meta-analysis about the effect of parental divorce on mental health among children. 17 So, the aim of this study was to conduct a systematic review of the relationship between childhood adversities and mental health problems.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Childhood adversities and mental health problems: A systematic review

Juwariah

Suhariadi

Soedirham

et al. 2022

Journal of Public Health Research

View full text Add to dashboard Cite

The number of mental health problems in children and adolescents has been increasing. One of the causes of mental health problems is trauma in the family, such as childhood adversities. The aim of this study was to review the relationship between childhood adversities and mental health problems. The method in this study was a systematic review using three databases: CINAHL, PubMed, and SCOPUS. The results of the review were reported according to the PRISMA guidelines. The keywords used in this study were mental health or mental illness or mental disorder or psychiatric illness AND adolescents or teenagers or teenagers or youth AND parental divorce or parental separation OR parental death or parental loss or parentally bereaved. The inclusion criteria for the articles were English language and published from 2017 to 2021. This study recorded 477 articles, screened according to the topic, and then the final articles were 35. The results of the systematic review showed evidence that childhood adversities were related to mental health problems according to the ICD-10 diagnosis, ADHD and personality disorders, depression, post-traumatic, smoking behavior, and alcohol abuse, and distress. Interventions for children with childhood adversities were needed to prevent mental health disorders.

show abstract

Effects of childhood adversity trajectories on mental health outcomes in late adolescence: The buffering role of parenting practices in Taiwan

Cited by 11 publications

References 72 publications

Dissecting early life stress-induced adolescent depression through epigenomic approach

Dissecting early life stress-induced adolescent depression through epigenomic approach

RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients

Childhood adversities and mental health problems: A systematic review

Contact Info

Product

Resources

About