Effects of Chinese herbal cataplasm Xiaozhang Tie on cirrhotic ascites

Feng, Xing; Tan, Youwen; Yan, Gong; Zhang, Jianjun; Shi, Zhaohong; Tan, Shanzhong; Feng, Nianping; Liu, Chenghai

doi:10.1016/j.jep.2011.10.040

Cited by 18 publications

(10 citation statements)

References 13 publications

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“…In the present study, XZT increased both 24 h urine and fecal water output, which contributed to its effect on ascites. Increases in diarrhea and fecal water content are also associated with gastrointestinal motility, and in a previous study, we observed that XZT could increase excretion and defecation, alleviating abdominal distention (Xing et al, 2012), and the results suggested that this finding was related to gastrointestinal motility. In the present study, the model rats had ascites and a delayed intestinal transit rate, but XZT ameliorated intestinal motility disorder in vivo and in vitro and increased fecal water content in the models, indicating that XZT action on ascites may be associated with the regulation of gastrointestinal motility.…”

Section: Discussionsupporting

confidence: 54%

“…The manufacturing procedures for the XZT and blank poultices were detailed by Xing et al (2012). XZT was extracted through ultrasonication in an aqueous solution of methanol, and essential oils were obtained using a hydrodistillation method.…”

Section: Compositional Analysis Of Xztmentioning

confidence: 99%

“…Our clinical trials indicated that XZT increased urine output and reduced the amount of ascites in patients with cirrhotic ascites without obvious side effects. In particular, after the initial application, it increased exhaust and defecation, improved appetite, and alleviated abdominal distention (Xing et al, 2012), suggesting that it could improve patients' gastrointestinal motility by acting on ascites.…”

Section: Introductionmentioning

confidence: 99%

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Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal

et al. 2020

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Section: Discussionsupporting

confidence: 54%

Section: Compositional Analysis Of Xztmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal

et al. 2020

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“…Traditional Chinese medicine (TCM) has a long history and rich experiences in treating cirrhotic ascites and, nowadays, is widely applied in clinical practice as a complementary and alternative approach. For example, Xiaozhang Tie - an adjuvant to the primary therapy of cirrhotic ascites - is safe and shows a remarkable efficacy on relieving abdominal distention [6]. …”

Section: Introductionmentioning

confidence: 99%

Serum Metabolomic Characteristics of Patients with Liver Cirrhotic Ascites

Yang¹,

Zheng²,

Feng³

et al. 2015

Integr Med Int

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Chronic hepatitis B is a common and frequently encountered disease in our country, the final outcome of which develops into liver cirrhosis and primary liver cancer.It was the aim of this study to provide a theoretical basis for the early diagnosis and treatment of liver cirrhosis. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS) is used to analyze endogenous bioactive substance change in healthy controls and patients with liver cirrhotic ascites. A metabolic fingerprint spectrum was established for the analysis. The results show that metabolic profiling of the serum indicates significant differences between the controls and the patients. Except for the tyrosine content which was decreased in the serum, the other 12 amino acids and 8 conjugated bile acids were significantly increased compared to controls (p < 0.01). Additionally, the 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) of serum were significantly decreased in the patients with liver cirrhotic ascites. In conclusion, the lysophosphatidylcholines C18:0, C18:2 and C16:1 are potential biomarkers. Moreover, the bile acid metabolism, amino acid metabolism and 5-HT as well as 5-HIAA metabolites are significantly changed in patients with cirrhotic ascites. These endogenous metabolites are potential biomarkers used for the diagnosis and treatment of liver fibrosis and cirrhosis.

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“…Euphorbia kansui contains 12 ingenols, as well as other active compounds including: sesquiterpenoids, triterpenoids, and euphols, which may all contribute to the biological activity of Euphorbia kansui [37–39]. Euphorbia kansui has been used for thousands of years for the treatment of fluid retention [40], cancer [41], and acities [42] in traditional Chinese herbal medicine. An oral dose of Euphorbia kansui results in minimal toxicity, mainly gastro-intestinal symptoms, such as diarrhea [43].…”

Section: Introductionmentioning

confidence: 99%

Euphorbia Kansui Reactivates Latent HIV

2016

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While highly active anti-retroviral therapy has greatly improved the lives of HIV infected individuals, these treatments are unable to eradicate the virus. Current approaches to reactivate the virus have been limited by toxicity, lack of an orally available therapy, and limited responses in primary CD4+ T cells and in clinical trials. The PKC agonist ingenol, purified from Euphorbia plants, is a potent T cell activator and reactivates latent HIV. Euphorbia kansui itself has been used for centuries in traditional Chinese medicine to treat ascites, fluid retention, and cancer. We demonstrate that an extract of this plant, Euphorbia kansui, is capable of recapitulating T cell activation induced by the purified ingenol. Indeed, Euphorbia kansui induced expression of the early T cell activation marker CD69 and P-TEFb in a dose-dependent manner. Furthermore, Euphorbia kansui reactivated latent HIV in a CD4+ T cell model of latency and in HIV+ HAART suppressed PBMC. When combined with the other latency reversing agents, the effective dose of Euphorbia kansui required to reactive HIV was reduced 10-fold and resulted in synergistic reactivation of latent HIV. We conclude that Euphorbia Euphorbia kansui reactivates latent HIV and activates CD4+ T cells. When used in combination with a latency reversing agent, the effective dose of Euphorbia kansui is reduced; which suggests its application as a combination strategy to reactivate latent HIV while limiting the toxicity due to global T cell activation. As a natural product, which has been used in traditional medicine for thousands of years, Euphorbia kansui is attractive as a potential treatment strategy, particularly in resource poor countries with limited treatment options. Further clinical testing will be required to determine its safety with current anti-retroviral therapies.

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Effects of Chinese herbal cataplasm Xiaozhang Tie on cirrhotic ascites

Cited by 18 publications

References 13 publications

Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal

Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal

Serum Metabolomic Characteristics of Patients with Liver Cirrhotic Ascites

Euphorbia Kansui Reactivates Latent HIV

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