Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins

Xue, Bin; Wang, Yuehua; Tian, Jinlong; Zhang, Weijia; Zang, Zhihuan; Cui, Hong; Zhang, Ye; Jiang, Qiao; Li, Bin; Liu, Rui Hai

doi:10.1016/j.foodchem.2021.130684

Cited by 12 publications

(4 citation statements)

References 40 publications

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Section: Resultsmentioning

confidence: 99%

“…In addition to the aforementioned studies, chitooligosaccharide-functionalized graphene oxide was fabricated and used as a nanocarrier to load blueberry anthocyanins and it showed improved bioaccessibility. 68 A combination of multiple encapsulation methods has also been used to encapsulate anthocyanins from grape skins. 69 Anthocyanins extracted from grape skin were encapsulated by sodium alginate-made hydrogels, followed by emulsion, spraydrying, or freeze-drying.…”

Section: Utilization Of Other Encapsulation Methodsmentioning

confidence: 99%

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Effects of encapsulation methods on bioaccessibility of anthocyanins: a systematic review and meta-analysis

2023

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Section: Resultsmentioning

confidence: 99%

Section: Utilization Of Other Encapsulation Methodsmentioning

confidence: 99%

Effects of encapsulation methods on bioaccessibility of anthocyanins: a systematic review and meta-analysis

2023

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“… b Di et al., 2018 ; Gong et al., 2019 ; Li, Gilbert et al., 2021 ; Liu, Du et al., 2021 ; Lyu et al., 2021 ; Mahajan et al., 2022 ; Peressini et al., 2020 ; Szwajgier et al., 2021 ; Tornero‐Martínez et al., 2019 ; Vamanu et al., 2020 ; Wu, Fu et al., 2021 ; Wu, Yuang et al., 2021 . c Ahmad & Gani, 2021 ; Vonghirundecha et al., 2022 ; Xue et al., 2022 . d Un et al., 2022 .…”

Section: In Vitro Gastrointestinal Digestion Enzymes Used In Products...unclassified

In vitro gastrointestinal digestion methods of carbohydrate‐rich foods

Dávila León,

González‐Vázquez,

Lima‐Villegas

et al. 2023

Food Science & Nutrition

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The trend toward healthier food products has led to an increase in the research of in vitro gastrointestinal digestion methods. Among the most used models, static models are the simplest. Most static models have three stages: oral, gastric, and intestinal, simulating the enzymatic, electrolyte, pH, temperature, and bile salt conditions. The studies that have taken the most notice are those related to antioxidant activity, followed by those dealing with proteins and carbohydrates using most of them static in vitro digestion models. The number of these studies has increased over the years, passing from 45 to 415 in a 10‐year period (2012–2023) and showing an interest in knowing the impact of food on human health. Nevertheless, published papers report different methodologies and analytical approaches. This review discusses the similarities and differences between the published static in vitro gastrointestinal digestion methods, with a focus on carbohydrates, finding that the most used protocol is Infogest, but with differences, mainly in the type of enzymes and their activity. Regarding in vitro gastrointestinal digestion of carbohydrates, many of the published studies are related to food and biomacromolecules, being the oral phase the most omitted, while the intestinal phase in the most diverse. Other methodologies to study the intestinal phase have been recommended, but the number of in vitro digestion studies using these methodologies (RSIE and BBMV) is still scarce but could represent a good alternative to analyze carbohydrates foods when combining with Infogest. More studies are required in this area.

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“…For efficient drug delivery applications, GO needs to be drug-loaded due to its confined dispersion in a physiological media. In order to improve the dispersion of GO, several physiologically active compounds (such as CS) have been employed [ 22 ]. Drug distribution and transportation occur through interaction between drug groups and GO functional groups, which is made possible by GO’s enormous surface area.…”

Section: Introductionmentioning

confidence: 99%

Development of pH-Responsive, Thermosensitive, Antibacterial, and Anticancer CS/PVA/Graphene Blended Hydrogels for Controlled Drug Delivery

Mansha,

Sajjad,

Zarbab

et al. 2024

Gels

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Drug delivery techniques based on polymers have been investigated for their potential to improve drug solubility, reduce systemic side effects, and controlled and targeted administration at infection site. In this study, we developed a co-polymeric hydrogel composed of graphene sheets (GNS), polyvinyl alcohol (PVA), and chitosan (CS) that is loaded with methotrexate (MTX) for in vitro liver cancer treatment. Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM) was employed to check the structural properties and surface morphology. Moreover, tests were conducted on the cytotoxicity, hemolytic activity, release kinetics, swelling behaviour and degradation of hydrogels. A controlled release of drug from hydrogel in PBS at pH 7.4 was examined using release kinetics. Maximal drug release in six hours was 97.34%. The prepared hydrogels did not encourage the HepG2 growth and were non-hemolytic. The current study highlights the potential of GNS-based hydrogel loaded with MTX as an encouraging therapy for hepatocellular carcinoma. HepG2 cell viability of MTX-loaded CS-PVA-GNS hydrogel was (IC50 5.87 µg/200 mL) in comparison to free MTX (IC50 5.03 µg/200 mL). These outcomes recommend that hydrogels with GNS ensure improved drug delivery in cancer microenvironment while lessening adverse consequences on healthy cells.

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Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins

Cited by 12 publications

References 40 publications

Effects of encapsulation methods on bioaccessibility of anthocyanins: a systematic review and meta-analysis

Effects of encapsulation methods on bioaccessibility of anthocyanins: a systematic review and meta-analysis

In vitro gastrointestinal digestion methods of carbohydrate‐rich foods

Development of pH-Responsive, Thermosensitive, Antibacterial, and Anticancer CS/PVA/Graphene Blended Hydrogels for Controlled Drug Delivery

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