Effects of chitooligosaccharides on the rebalance of gut microorganisms and their metabolites in patients with nonalcoholic fatty liver disease

Ji, Xiaoguo; Chen, Mai; Zhao, Mengyao; Song, Yudong; Lin, Yong; Yin, Hao; Zhao, Liming

doi:10.1016/j.jff.2020.104333

Cited by 13 publications

(19 citation statements)

References 50 publications

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“…Interestingly, the ameliorated cell redox state and mitigated ammonia levels could contribute to the documented protective effects of COS against hepato- and neuro-inflammations. Our observations are supported by previous studies, which commonly reported that hepatotoxicity could be attenuated by the capability of oligosaccharides due to their potent antioxidant and anti-inflammatory properties …”

Section: Discussionsupporting

confidence: 92%

“…As glucosamine oligomers with good solubility, high absorption rate, and noncytotoxicity, COSs have attracted a lot of attention due to their diverse biological activities . Many studies have demonstrated that COSs possess numerous biological activities and pharmacological functions, such as antioxidation, antibacterial, antidiabetes, anticancer, and immunomodulatory activity. , Because of the characteristics of COS, they have been considered to be new potential prebiotics, and utilized in numerous industries including food, medicine, and agriculture. Moreover, the interactions with gut microbiota might affect the biological functions of COS .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the interactions with gut microbiota might affect the biological functions of COS . Recent study suggested that COS could increase antioxidant activity, enhance liver function, and optimize the intestinal microbial community structure, thus COSs have been utilized to treat and prevent nonalcoholic fatty liver disease …”

Section: Introductionmentioning

confidence: 99%

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Ameliorative Effect of Chitosan Oligosaccharides on Hepatic Encephalopathy by Reshaping Gut Microbiota and Gut–Liver Axis

Wang

et al. 2022

J. Agric. Food Chem.

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This study investigated the influence of chitosan oligosaccharides (COSs) on a thioacetamide-induced hepatic encephalopathy (HE) Wistar rat model. COS treatment statistically reduced the false neurotransmitters and blood ammonia in HE rats, along with the suppression of oxidative stress and inflammation. The disbalanced gut microbiota was detected in HE rats by 16S rDNA sequencing, but the abundance alterations of some intestinal bacteria at either the phylum or genus level were at least partly restored by COS treatment. According to metabolomics analysis of rat feces, six metabolism pathways with the greatest response to HE were screened, several of which were remarkably reversed by COS. The altered metabolites might serve as a bridge for the alleviated HE rats treated with COS and the enhanced intestinal bacterial structure. This study provides novel guidance to develop novel food or dietary supplements to improve HE diseases due to the potential beneficial effect of COS on gut–liver axis.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Ameliorative Effect of Chitosan Oligosaccharides on Hepatic Encephalopathy by Reshaping Gut Microbiota and Gut–Liver Axis

Wang

et al. 2022

J. Agric. Food Chem.

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“…C. sensu stricto may ferment undigested carbohydrates and amino acids into short-chain fatty acids ( Lopetuso et al., 2013 ). Butyrate is the main source of energy for epithelial enterocytes, and can inhibit inflammation and improve lipid metabolism ( Lopez-Siles et al., 2012 ; Ji et al., 2021 ). C. sensu stricto 12 is a potential butyrate producer ( Liu et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

A new single-cell protein from Clostridium autoethanogenum as a functional protein for largemouth bass (Micropterus salmoides)

Liang²,

Chen³

et al. 2022

Animal Nutrition

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“…COS with DPs varying from two to three can enrich the butyric acid-producing Clostridium and Parabacteroides, and COS with DPs four to six could generate a diverse microbiota profile, as well as increase their metabolic functions [160]. Chitobiose and chitotriose were also reported to target different bacteria communities [171].…”

Section: Prebioticmentioning

confidence: 99%

Chitin oligosaccharides for the food industry: production and applications

Zhang

Zhao

et al. 2022

Syst Microbiol and Biomanuf

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Chitin oligosaccharides (CHOS), high-value-added oligomers linked by N-acetyl-d-glucosamine (GlcNAc, NAG), and a small amount of d-glucosamine (GlcN, GA), have aroused increasing interest due to their excellent biological properties, including antibacterial, anti-inflammatory, and immunoprotective activities, and intestinal regulation. The efficient production and utilization of CHOS with high performance can solve problems from chitin as biowaste. However, the large-scale production of well-defined CHOS has not been fully accomplished due to the limited biotechnology and separation methods, thus impeding the research on their biological functions as well as their accurate applications. In this review, we comprehensively summarize the current preparation methods of CHOS, including the chemical, physical, enzymatic and biosynthetic methods. The advantages and disadvantages of the methods are discussed in terms of efficiency, economy, and environmental effects. Furthermore, the applications of CHOS in the food industry and their contributions to human health based on their excellent bioactivities are expounded. It is hoped that this review will help in providing new insights into the production of CHOS with high precision, and support the application of CHOS in serving the food industry as nutritional supplements or foods for special medical purposes. KeywordsChitin • Chitin oligosaccharides • Chitooligosaccharides • Production • Food applications Abbreviations CHOS Chitin oligosaccharides; N-acetyl chitooligosaccharides COS Chitooligosaccharides GlcNAc, NAG N-Acetyl-d-glucosamine GlcN, GA d-Glucosamine

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Effects of chitooligosaccharides on the rebalance of gut microorganisms and their metabolites in patients with nonalcoholic fatty liver disease

Cited by 13 publications

References 50 publications

Ameliorative Effect of Chitosan Oligosaccharides on Hepatic Encephalopathy by Reshaping Gut Microbiota and Gut–Liver Axis

Ameliorative Effect of Chitosan Oligosaccharides on Hepatic Encephalopathy by Reshaping Gut Microbiota and Gut–Liver Axis

A new single-cell protein from Clostridium autoethanogenum as a functional protein for largemouth bass (Micropterus salmoides)

Chitin oligosaccharides for the food industry: production and applications

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