Effects of chitosan on oxidative stress and related factors in hemodialysis patients

Anraku, Makoto; Tanaka, Motoko; Hiraga, Ayumu; Nagumo, Kohei; Imafuku, Tadashi; Maezaki, Yuji; Iohara, Daisuke; Uekama, Kaneto; Watanabe, Hiroshi; Hirayama, Fumitoshi; Maruyama, Toru; Otagiri, Masaki

doi:10.1016/j.carbpol.2014.05.078

Cited by 40 publications

(18 citation statements)

References 24 publications

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“…As by increasing the chitosan content of HFD, in presence of calcium and vitamin supplements, significant reductions were recorded in the levels of all lipid variables in serum, except for marked elevations in HDL-C. This can be attributed to the ability of chitosan to bind lipids in the intestine impeding their absorption (Anraku et al, 2014). Moreover, the increased levels of HDL-C can enhance lipid transport to the liver for further elimination with bile acids (Abdel--Ghaffar, Ali, & Soliman, 2018).…”

Section: Discussionmentioning

confidence: 99%

Ameliorative role of a combination of chitosan, calcium, vitamins A and E against high fat diets-induced adverse effects in rats

Ali¹,

Mansour²,

Hassanine³

et al. 2019

JoBAZ

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Background: Chitosan is a promising natural source for controlling obesity. Obese people tend to use supplementary nutrients to compensate for their deficiencies in their diets. The present study aimed to investigate the combined effect of chitosan, calcium, and vitamins A and E supplements against the adverse effects of high-fat diet consumption in rats. Methods: Twenty-five male albino rats were assigned into five equal groups. Control rats were fed standard basal diet (SBD). Another group was fed high-fat diet (HFD) without supplements. The other three groups were fed HFD containing 0, 400, and 800 mg of chitosan per kilogram diet, in presence of calcium and vitamins A and E supplements, daily for 10 weeks. Results: As compared to controls, rats fed HFD without supplements showed significant elevations in body weight gain, feed consumption, relative weights of the heart and liver, serum levels of total cholesterol, triglycerides, low-density lipoprotein cholesterols, very low-lipoprotein triglycerides, urea, creatinine, and malondialdehyde, as well as serum activities of alanine and aspartate aminotransferases, alkaline phosphatase, and creatine kinase. Moreover, significant declines in the relative kidney weight, serum levels of high-density lipoprotein cholesterols, total proteins, albumin, globulin, calcium, vitamins A and E, erythrocyte glutathione content, and superoxide dismutase activity were recorded. Histopathological alterations were observed in rats fed HFD with or without supplements. On contrary, rats fed HFD containing chitosan and supplements showed remarkable improvement in all the studied parameters towards control values, in dose-dependent manner. Conclusion: Chitosan, calcium, and vitamins A and E attenuated the adverse effects caused by HFD intake in rats.

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Section: Discussionmentioning

confidence: 99%

Ameliorative role of a combination of chitosan, calcium, vitamins A and E against high fat diets-induced adverse effects in rats

Ali¹,

Mansour²,

Hassanine³

et al. 2019

JoBAZ

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“…In a study conducted on the rats that went through hemodialysis, it was found out that chitosan decreased the serum indoxyl sulphate level in 38.5% and oxidized albumin level in 15.3% compared to the control group. It is suggested that those results would promote to reduce the stress on the hemodialysis patients and would increase the total plasma antioxidant capacity at the same time [23].…”

Section: Its Antioxidant Featurementioning

confidence: 99%

A Renewable Natural Bioactive Polysaccharide: An Overview to Chitosan

Ayhan¹,

Şanlıer²

2015

IJNFS

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Chitin is a polysaccharide, which can be found in the structures of some insects, yeasts and fungi in nature.Chitosan is a compound, which is obtained by de -acetylation of chitin. Apart from that, there is chitosan naturally on the cell walls of some fungi, in yeasts and protozoa and in the outer shells of crustaceans. Chitosan is a molecule, which is frequently used in health field and food industry. It is frequently used in bioactive packing especially for its antibacterial effect. In addition, it is used in many areas such as waste treatment for its antioxidant feature. Areas of use of chitosan are expanding because it is an edible agent and because of its low level of toxic activity, and new areas of use are discovered everyday in good and health sectors.

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“…Our recent studies suggest a new potential use for chitosan and nanofibers produced from it, as an alternative to AST-120 and as an antioxidant in CRF. Thus, from the perspective of antioxidant therapy, the use of nanofibers derived from chitosan would be preferable at a stage earlier than the conventional state of pre-dialysis uremia, where AST-120 is routinely prescribed, because such chitosanrelated products are widely used as a health food product and not a medicine [12][13][14]. It is noteworthy that another type of ampholytic polysaccharide, Sacran (Figure 1) is extracted from the Japanese indigenous Cyanobacterium Aphanothece sacrum, which is mass-aquacultured in rivers.…”

Section: Introductionmentioning

confidence: 99%

Sacran, a High-molecular Weight Polysaccharide Inhibits Renal Injury and Oxidative Stress in Chronic Renal Failure Model Rats

Goto¹,

Iohara²,

Kaneko³

et al. 2018

JNB

Self Cite

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The administration of a high-molecular polysaccharide Sacran results in a significant decrease in renal injury and oxidative stress, compared with that for the oral carbonaceous adsorbent, AST-120 (Kremezin®) or a non-treatment group in 5/6 nephrectomized rats. An oral administration of Sacran (20 mg/day) over a 4 week period resulted in a significant decrease in serum indoxyl sulfate, creatinine and urea nitrogen levels, compared with a similar treatment with AST-120 or the non-treatment group. Sacran treatment also resulted in antioxidant potential being maintained, compared with that for AST-120 or the non-treatment group. Immuno-histochemical analyses also demonstrated that CRF rats, when treated with Sacran, showed a decrease in the level of accumulated renal fibrosis and 8-OHdG compared with AST-120 or the non-treatment group. These results suggest that the ingestion of Sacran results in a significant reduction in the levels of prooxidants, such as uremic toxins, in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation.

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Effects of chitosan on oxidative stress and related factors in hemodialysis patients

Cited by 40 publications

References 24 publications

Ameliorative role of a combination of chitosan, calcium, vitamins A and E against high fat diets-induced adverse effects in rats

Ameliorative role of a combination of chitosan, calcium, vitamins A and E against high fat diets-induced adverse effects in rats

A Renewable Natural Bioactive Polysaccharide: An Overview to Chitosan

Sacran, a High-molecular Weight Polysaccharide Inhibits Renal Injury and Oxidative Stress in Chronic Renal Failure Model Rats

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