Effects of chlordecone and malnutrition on immune response in rats

Chetty, Kothapa N.; Brown, K.L.; Walker, J.; Woods, Lester

doi:10.1016/0024-3205(93)90114-i

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…One study with rats fed calcium-deficient diets found an increase in plaque-forming cells at the lowest dose tested (0.5 mg/kg/day). The effect on plaque-forming cells was found to be more severe in calcium-sufficient animals than in calcium-deficient animals (Chetty et al, 1993c).…”

Section: Immunological Effectsmentioning

confidence: 86%

“…The limitations of these studies include lack of information on cell-mediated functions, such as alloantigen reactivity and cytotoxicity, and on humoral immunity in the treated animals; however, as part of a study in male Sprague-Dawley rats of the effects of calcium deficiency on the toxicity of chlordecone, an increase in plaque-forming cells was observed at the lowest dose tested (0.5 mg/kg/day) (Chetty et al, 1993c). A significant reduction of thymus weight was also observed in Sprague-Dawley rats three weeks after a single oral dose of 75 mg/kg of chlordecone (Swanson and Woolley, 1982).…”

Section: Immunological and Lymphoreticular Effectsmentioning

confidence: 99%

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Atsdr Evaluation of Health Effects of Chemicals

et al. 1995

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This document provides public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective of the toxicology of mirex and chlordecone. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. Additional substances will be profiled in a series of manuscripts to follow.

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Section: Immunological Effectsmentioning

confidence: 86%

Section: Immunological and Lymphoreticular Effectsmentioning

confidence: 99%

Atsdr Evaluation of Health Effects of Chemicals

et al. 1995

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A Review on Experimental Models for Screening Plant Food and Human Nutrition

Majumdar¹,

Pandey²,

Shukla³

et al. 2022

CNF

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Background: Malnutrition is the common universal health problem but it is more chronic for the developing countries. Due to increasing nursing home recognition it has become a major research priority, internationally. Lower immunity due to malnutrition has a high prevalence and other clinical consequences. Disease-related malnutrition is potentially severe for patients along with high economic impact on the healthcare system. Objectives: The aim of this review is to described various experimental models employed for evaluation of malnutrition and immunomodulatory activities. Methods: This review is intended for both clinicians and researchers describing number of screening methods that better suits to the type of lead compounds and suitability to screen molecules for better treatment outcomes. Results: This review focuses on the various screening methods for evaluation of malnutrition and suggests implications for research and practice. Conclusion: The malnutrition induced diseases cause a raise in health care costs than can be minimized with an introduction of drugs and nutritional supplements by selecting proper screening models and performing exhaustive research.

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Effects of chlordecone and malnutrition on immune response in rats

Cited by 2 publications

References 11 publications

Atsdr Evaluation of Health Effects of Chemicals

Atsdr Evaluation of Health Effects of Chemicals

A Review on Experimental Models for Screening Plant Food and Human Nutrition

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