Effects of chlorogenic acid, caffeine, and coffee on behavioral and biochemical parameters of diabetic rats

Abstract

Diabetes mellitus (DM) is associated with brain alterations that may contribute to cognitive dysfunctions. Chlorogenic acid (CGA) and caffeine (CA), abundant in coffee (CF), are natural compounds that have showed important actions in the brain. The present study aimed to evaluate the effect of CGA, CA, and CF on acetylcholinesterase (AChE), Na(+), K(+)-ATPase, aminolevulinate dehydratase (δ-ALA-D) activities and TBARS levels from cerebral cortex, as well as memory and anxiety in streptozotocin-induced diabetic rats. Animals were divided into eight groups (n = 5-10): control; control/CGA 5 mg/kg; control/CA 15 mg/kg; control/CF 0.5 g/kg; diabetic; diabetic/CGA 5 mg/kg; diabetic/CA 15 mg/kg; and diabetic/CF 0.5 g/kg. Our results demonstrated an increase in AChE activity and TBARS levels in cerebral cortex, while δ-ALA-D and Na(+), K(+)-ATPase activities were decreased in the diabetic rats when compared to control water group. Furthermore, a memory deficit and an increase in anxiety in diabetic rats were observed. The treatment with CGA and CA prevented the increase in AChE activity in diabetic rats when compared to the diabetic water group. CGA, CA, and CF intake partially prevented cerebral δ-ALA-D and Na(+), K(+)-ATPase activity decrease due to diabetes. Moreover, CGA prevented diabetes-induced TBARS production, improved memory, and decreased anxiety. In conclusion, among the compounds studied CGA proved to be a compound which acts better in the prevention of brain disorders promoted by DM.

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

“…Recent researches on chlorogenic acid suggest that it inhibits DNA damage and lipid peroxidation by increasing the resistance of low-density lipoprotein (Wan et al 2013) and prevents carcinogenesis by reducing DNA damage (Rakshit et al 2010;Ooi et al 2011). It has also been reported to have analgesic (Hara et al 2014), antiinflammatory (Hwang et al 2014), antidiabetic (Stefanello et al 2014), and antibacterial effects (Ozçelik et al 2011). Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a benzoic acid derivative found in plant and fruits that is being used as a preservative and antiseptic agent in cosmetic, food, and pharmaceutical industries.…”

Evaluation of phenolic compounds and lipid-lowering effect of Morus nigra leaves extract

“…Furthermore, Padma et al (2012) demonstrated reduction in lipid levels peroxidation in all structures tested significantly (Figure 4a, b, c and d). Therefore, chlorogenic acid and quercetin, both identified in the infusion of M. nigra, were capable to decrease MDA levels in serum, erythrocytes, cerebral cortex, hippocampus and liver (Jung et al 2009, Meng et al 2013, Stefanello et al 2014, Xia et al 2015, Imessaouedene et al 2016.…”

Hyperglycemia alters E-NTPDases, ecto-5′-nucleotidase, and ectosolic and cytosolic adenosine deaminase activities and expression from encephala of adult zebrafish (Danio rerio)

“…One possible strategy to correct the changes in synaptic efficiencies caused by DM can be through of analysis of the presynaptic neuromodulation systems, as purinergic system [11,12]. Adenine nucleotides represent an important class of extracellular molecules involved in modulation of signaling pathways that are essential to the normal functioning of the central nervous system (CNS) [13].…”