Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial

Enokuchi, Yuka; Suzuki, Atsushi; Yamaguchi, Tohru; Ochiai, Ryuji; Terauchi, Masakazu; Kataoka, Kiyoshi

doi:10.3390/nu12123757

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…CGAs significantly decreased the modified Kupperman index of menopausal symptoms and reduced the number of hot flushes, the severity of hot flushes during sleep, and the severity of daytime sweats compared to the placebo group. No adverse effects were observed in the CGAs group [341].…”

Section: Human Subject Studies For Menopausal Symptom Managementmentioning

confidence: 80%

Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Nguyen,

Taine,

Meng

et al. 2024

Nutrients

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Chlorogenic acid (CGA) is a type of polyphenol compound found in rich concentrations in many plants such as green coffee beans. As an active natural substance, CGA exerts diverse therapeutic effects in response to a variety of pathological challenges, particularly conditions associated with chronic metabolic diseases and age-related disorders. It shows multidimensional functions, including neuroprotection for neurodegenerative disorders and diabetic peripheral neuropathy, anti-inflammation, anti-oxidation, anti-pathogens, mitigation of cardiovascular disorders, skin diseases, diabetes mellitus, liver and kidney injuries, and anti-tumor activities. Mechanistically, its integrative functions act through the modulation of anti-inflammation/oxidation and metabolic homeostasis. It can thwart inflammatory constituents at multiple levels such as curtailing NF-kB pathways to neutralize primitive inflammatory factors, hindering inflammatory propagation, and alleviating inflammation-related tissue injury. It concurrently raises pivotal antioxidants by activating the Nrf2 pathway, thus scavenging excessive cellular free radicals. It elevates AMPK pathways for the maintenance and restoration of metabolic homeostasis of glucose and lipids. Additionally, CGA shows functions of neuromodulation by targeting neuroreceptors and ion channels. In this review, we systematically recapitulate CGA’s pharmacological activities, medicinal properties, and mechanistic actions as a potential therapeutic agent. Further studies for defining its specific targeting molecules, improving its bioavailability, and validating its clinical efficacy are required to corroborate the therapeutic effects of CGA.

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Section: Human Subject Studies For Menopausal Symptom Managementmentioning

confidence: 80%

Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Nguyen,

Taine,

Meng

et al. 2024

Nutrients

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“…The menstrual status assessment refers to The International Federation of Gynecology and Obstetrics (IFGO) Recommendations on Terminologies and Definitions for Normal and Abnormal Uterine Bleeding[28], as defined by the following parameters. The modified Kupperman Menopausal Index is widely used internationally, and its role in clinical practice is well established[29-31]. Perimenopausal symptoms have different basic scores and degree scores, helping to rank their impact.…”

Section: Methodsmentioning

confidence: 99%

“…Terminologies and Definitions for Normal and Abnormal Uterine Bleeding [28], as defined by the following parameters. The modified Kupperman Menopausal Index is widely used internationally, and its role in clinical practice is well established [29][30][31].…”

Section: Federation Of Gynecology and Obstetrics (Ifgo) Recommendatio...mentioning

confidence: 99%

Efficacy of electroacupuncture versus transcutaneous electrical acupoints stimulation on subclinical premature ovarian insufficiency: study protocol for a randomized controlled trial

Wang

Dai

et al. 2022

Preprint

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Introduction: "Subclinical stage" of premature ovarian insufficiency (POI) refers to menstrual disorders with FSH levels in the range of 15-25 U/L in women under 40 years old caused by diminished ovarian function. Early intervention of subclinical POI may be able to protect ovarian function more effectively and prevent further development to POI. Currently, no standard-of-care exists for subclinical POI. Previous studies have shown effectiveness of electroacupuncture (EA) on POI and transcutaneous electrical acupoint stimulation (TEAS) on diminished ovarian reserve, but no published studies focus on the treatment of subclinical POI. This study aims to assess whether EA or TEAS will be effective in improving ovarian function at the subclinical stage of POI and preventing the progression. Methods: 114 subclinical POI patients between 25 and 40 years will be randomly assigned to three groups (an EA group, a TEAS group and a waiting for treatment group) in this randomized, controlled, assessor-blinded trial. The treatment will last for three months and the follow-up will last for twelve months. The primary outcomes will be anti-Mullerian hormone (AMH) and follicle-stimulating hormone (FSH). Secondary outcomes will include serum estradiol (E2), luteinizing hormone (LH), FSH/LH ratio, the menstrual status assessment, and modified Kupperman Menopausal Index. We will also investigate the incidence of adverse events. Trial registration: Trial was registered in the Chinese Clinical Trail Registry (ChiCTR-2100045598); Pre-results.

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“…Polyphenols (Enokuchi et al, 2020;Taher et al, 2013;Terauchi et al, 2014) and botanical supplements, such as St John's Wort (Liu et al, 2014), evening primrose oil (Farzaneh et al, 2013;Kazemi et al, 2021), sage (Bommer et al, 2011), milk thistle (Saberi et al, 2020), ginseng (Lee et al, 2016(Lee et al, , 2022 and combined botanical supplements (Rattanatantikul et al, 2022) have been explored. Despite some studies reporting positive results, concerns about methodology, study heterogeneity and insufficient large-scale interventions mean it is not possible to conclude whether a causal relationship exists for reducing VMS.…”

Section: Other Botanical Supplementsmentioning

confidence: 99%

The role of diet in managing menopausal symptoms: A narrative review

et al. 2023

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Menopause is a natural stage that occurs when women stop menstruating, during which many women experience physical and psychological symptoms that can affect their quality of life and ability to work. Dietary modifications and food supplements may be explored by some women as alternatives to hormone replacement therapy, although existing reviews and expert position statements have given this limited consideration. This narrative review summarises the current evidence for dietary patterns, and botanical and food supplements, in the management of common menopausal symptoms, including vasomotor symptoms (VMS; hot flushes; night sweats), changes in bodyweight and composition, psychological symptoms (depression; anxiety; cognitive changes), sleep disturbances, joint pain, skin changes and urogenital symptoms. Soy isoflavones may reduce the frequency and/or severity of VMS, although results are inconsistent, and it is unclear whether dietary and supplemental sources have comparable effects. Adopting a healthier dietary pattern may support a healthy bodyweight and benefit VMS. However, evidence suggesting dietary patterns may benefit depression, anxiety, and cognition remains largely observational. While some botanicals, such as black cohosh and St John's Wort, have been reported in some studies to alleviate symptoms (such as VMS and depression), these are not currently recommended due to uncertainty about the appropriate dose and preparation, and potential safety concerns. Evidence for other symptoms is currently too limited to draw conclusions. While further trials at different menopausal stages are needed, adopting a healthier dietary pattern in accordance with dietary guidelines is likely to help support women's health before, during and after the menopausal transition.

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Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial

Cited by 7 publications

References 34 publications

Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Efficacy of electroacupuncture versus transcutaneous electrical acupoints stimulation on subclinical premature ovarian insufficiency: study protocol for a randomized controlled trial

The role of diet in managing menopausal symptoms: A narrative review

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