Effects of Chloroquine on Patients with Cutaneous Porphyria of the "Symptomatic" Type

Porphyrias and the Kidney

“…: Personal commun., 1980], Why should chloroquine facilitate the release of these excess por phyrins from hepatocytes in nonuremic PCT cases, but not in patients on dialysis? The simplest answer, again, is that the bulk of these urinary porphyrins in nonuremic PCT originates in the kidney and, as chloroquine is known to accumulate in the kidney as well as in the liver [27], the former is the organ where it has its major porphyrinmobilizing effect. Hence, in dialysis patients, insignificant renal porphyrin synthesis occurs because the organs are not functional, whilst only slight quantities of porphyrin leak into the plasmas of these patients from their hepato cytes since, as in the HCB-poisoned rats described earlier [14], most of the excess porphyrins synthesized in the liver accumulate without excretion.…”

Antiinfectiosa

“…Schliesslich kann, vor allem durch Chloroquin, eine Porphyria cutanea tarda vorübergehend verschlimmert werden («Chloroquinreaktion»: Haut exazerbation und grippeartiger Fieberzustand: 177, 402a), um jedoch an schliessend für Monate, vielleicht Jahre, sowohl klinisch als auch bioche misch teilweise [184,693] …”

The porphyrias: a review.

“…The large amount of porphyrin stored in the liver underlies the unique response of patients with this condition to chloroquine administration, which produces a transient febrile reaction accompanied by massive uroporphyrinuria and biochemical evidence of liver cell damage (Sweeney, Saunders, Dowdle, and Eales, 1965;Felsher and Redeker, 1966). Chloroquine forms a complex with porphyrins and an abnormally high intracellular concentration may account for its hepatotoxic action in these patients (Scholnick and Marver, 1968 (Taddeini and Watson, 1968).…”