2002
DOI: 10.1007/bf03032152
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Effects of chlorpromazine as a systemic vasodilator during cardiopulmonary bypass in neonates

Abstract: Chlorpromazine effectively counteracts systemic vasoconstriction induced by cardiopulmonary bypass without serious side effects in neonatal cardiac surgery.

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Cited by 13 publications
(9 citation statements)
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“…(2) As far as possible, a staged Fontan procedure with an extracardiac conduit was performed with a beating heart. 37 (3) Large doses of an ␣-blocking agent (chlorpromazine at 1-2 mg/kg) were used during CPB, 38 and a 2-g/(kg · min) infusion of nitroglycerin and inhalation of 100% oxygen with 5 to 20 ppm nitric oxide were performed on weaning from CPB. 39 (4) Longterm oral intakes of an angiotensin-converting enzyme inhibitor or ␤-blocker were adopted as an afterload-reducing therapy.…”
Section: Discussionmentioning
confidence: 99%
“…(2) As far as possible, a staged Fontan procedure with an extracardiac conduit was performed with a beating heart. 37 (3) Large doses of an ␣-blocking agent (chlorpromazine at 1-2 mg/kg) were used during CPB, 38 and a 2-g/(kg · min) infusion of nitroglycerin and inhalation of 100% oxygen with 5 to 20 ppm nitric oxide were performed on weaning from CPB. 39 (4) Longterm oral intakes of an angiotensin-converting enzyme inhibitor or ␤-blocker were adopted as an afterload-reducing therapy.…”
Section: Discussionmentioning
confidence: 99%
“…Imoto et al studied the effects of chlorpromazine as a systemic vasodilator administered during CPB in neonatal cardiac surgery, they found that the rate of rise of core temperature didn't differ significantly between the chlorpromazine and control group, while the rate of rise in peripheral temperature is significantly higher in chlorpromazine group indicating more homogenous heat distribution. They found also that urine output is significantly higher in chlorpromazine group than the control group [10]. The adequacy of tissue perfusion during CPB is monitored by lactate level, base excess and urine output.…”
Section: Heart Rate (Beat/min)mentioning
confidence: 99%
“…Dopamine receptor antagonists have been used extensively in children to treat nausea and vomiting from a variety of etiologies(29-33), and they are commonly used for this purpose in the emergency room setting(30, 31). Chlorpromazine has also been used to treat children with psychiatric disorders(34, 35) and even to provide systemic vasodilation in neonates undergoing cardiac surgery(36). With regards to pediatric migraine, intravenous dopamine receptor antagonists were the parenteral agents prescribed most frequently in pediatric emergency rooms(8).…”
Section: Principles and Evidence Regarding Pediatric Migraine Therapymentioning
confidence: 99%