Effects of chlorpromazine on pattern and flash ERGs and VEPs compared to oxazepam and to placebo in normal subjects

Bartel, Peter; Blom, M. W.; Robinson, Elna; Meyden, C. van der; Sommers, De K.; Becker, P J

doi:10.1016/0168-5597(90)90054-h

Cited by 31 publications

(21 citation statements)

References 20 publications

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“…Bartel et al [23] did not find overall significant effects of a single oral dose of oxazepam (15 mg) on pattern electroretinogram and visual evoked potentials. Only a decrease of the b wave latency of the ERG and an increase in the OP4 latency of the VEP were observed.…”

Section: Introductionmentioning

confidence: 99%

GABA‐ergic control of visual perception in healthy volunteers: effects of midazolam, a benzodiazepine, on spatio‐temporal contrast sensitivity.

Blin¹,

Mestre²,

Paut³

et al. 1993

Brit J Clinical Pharma

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1. We studied the effects of midazolam (MDZ), a benzodiazepine, on spatio‐temporal contrast sensitivity, choice reaction time, and mood visual analogue scales in healthy volunteers. 2. Eight extensively trained, healthy volunteers were included in a placebo‐controlled cross‐ over double‐blind trial of MDZ (0.15 mg kg‐1). Treatments were injected intramuscularly and evaluations were performed before and 0.5, 1, 2, 3 and 4 h after drug administration. Spatio‐temporal contrast sensitivity was measured using a micro‐computer with appropriate software. Stimuli were vertical gratings with adjustable contrast, with spatial frequencies of 0.25, 1 and 4 cpd. Four conditions of temporal modulation were used: the grating was either static or drifting laterally with temporal frequencies of 1, 3 and 9 Hz. 3. An analysis of variance was performed on the data. As compared with placebo, MDZ induced an increase in choice reaction time and sedation (as assessed on visual analogue scales). From 0.5‐4 h after the injection, MDZ produced an overall decrease in visual sensitivity, as compared with placebo. More specifically, MDZ preferentially affected medium to high spatial frequencies and low temporal frequencies. Several non‐exclusive hypotheses may account for the results: 1) an increase in the size of the receptive fields, 2) a preferential effect on the visual parvocellular pathways which mediate the sensitivity to high spatial and low temporal frequencies.

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Section: Introductionmentioning

confidence: 99%

GABA‐ergic control of visual perception in healthy volunteers: effects of midazolam, a benzodiazepine, on spatio‐temporal contrast sensitivity.

Blin¹,

Mestre²,

Paut³

et al. 1993

Brit J Clinical Pharma

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“…Applying essentially the same battery of ERGs and VEPs which we have previously shown to be sensitive to antidopaminergic drugs [10,14], the present study has failed to provide convincing evidence of anticholinergic effects. It was anticipated and supported by findings that biperiden would have greater central effects (sedation) than atropine, but biperiden failed to cause any signifi cant ERG effects.…”

Section: Discussionmentioning

confidence: 55%

“…12]. The battery of ERG/VEP recordings has been previously described in detail [10]. There were, however, some changes to the recording methods and these are specified in this section.…”

Section: Methodsmentioning

confidence: 99%

Effects of Two Anticholinergic Drugs on Electroretinograms and Visual Evoked Potentials in Healthy Human Subjects

Bartel¹,

Blom²,

Robinson³

et al. 1990

Neuropsychobiology

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A battery of electroretinograms (ERGs) and visual evoked potentials (VEPs) were recorded from 12 normal, male volunteers after the intravenous administration of either biperiden 2.5 mg, atropine 1.5 mg or placebo, at weekly intervals. Self-reports indicated that both drugs caused significantly reduced levels of alertness compared to placebo, but more so with biperiden than atropine. Biperiden was not, however, associated with significant changes to ERGs, while atropine caused a few isolated, significant increases to implicit times. There were no significant treatment effects on pattern ERGs or VEPs. The flash VEP latencies and amplitudes recorded after the anticholinergics did not differ from placebo. These preliminary findings suggest that these anticholinergics do not have marked effects on either ERGs or VEPs.

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“…The recording methods have been described in detail previously [7]. The derivation used for PERG recordings consisted of a gold foil electrode seated in the lower fornix of the left eye and an electrode placed i cm lateral to the outer canthus.…”

Section: Methodsmentioning

confidence: 99%

The intrasession repeatability of pattern electroretinograms and the effects of digital filtering

Bartel

Becker²,

Robinson

1991

Doc Ophthalmol

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Transient pattern electroretinograms were recorded in 12 normal young volunteers with the use of 12' and 30' checkerboard stimuli and 1 c/deg and 2.5 c/deg vertical gratings. The intrasession repeatability of pattern electroretinograms was determined by employing alternative statistics to the frequently used correlation coefficients. Comparisons were made with the repeatability of cone electroretinograms elicited by ganzfeld stimulation. The coefficient of repeatability was substantially lower (better) for pattern electroretinogram b-wave implicit times than for a-wave implicit times and b-wave amplitudes, the latter having high coefficients of repeatability. Cone electroretinograms had better repeatability with respect to all three parameters. Digital filtering using a bandpass of 1-40 Hz was applied to the original pattern electroretinograms recorded with a bandpass of 1-250 Hz. Although peak definition was generally enhanced, repeatability did not show marked improvement. Differences between broadband analogue-filtered pattern electroretinograms and the same responses with high-frequency noise removed by digital filtering need to be taken into account. The coefficient of repeatability statistic appears to facilitate the assessment of pattern electroretinograms and permits the comparison of the repeatability of both implicit time and amplitude parameters irrespective of absolute values. The implications of the relatively poor repeatability of pattern electroretinogram b-wave amplitudes for clinical applications need to be considered.

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Effects of chlorpromazine on pattern and flash ERGs and VEPs compared to oxazepam and to placebo in normal subjects

Cited by 31 publications

References 20 publications

GABA‐ergic control of visual perception in healthy volunteers: effects of midazolam, a benzodiazepine, on spatio‐temporal contrast sensitivity.

GABA‐ergic control of visual perception in healthy volunteers: effects of midazolam, a benzodiazepine, on spatio‐temporal contrast sensitivity.

Effects of Two Anticholinergic Drugs on Electroretinograms and Visual Evoked Potentials in Healthy Human Subjects

The intrasession repeatability of pattern electroretinograms and the effects of digital filtering

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