Effects of Cholera Enterotoxin, Glucagon, and Dibutyryl Cyclic Amp on Rat Liver Alkaline Phosphatase, Bile Flow, and Bile Composition

Baker, Alfred L.; Kaplan, Marshall M.

doi:10.1016/s0016-5085(76)80499-4

Cited by 12 publications

(3 citation statements)

References 21 publications

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“…Stimulation of this fraction of bile production was also seen in rats and cats (Balabaud et al 1976. Larsen et al 1979, but the effect could not be mimicked by DBcAMP in rats (Baker & Kaplan 1976) and cats (Larsen et al 1979). Shaw & Heath (1973) and Baker & Kaplan (1976) did not find any effect of glucagon on bile production in the rat and Morris eL al.…”

Section: (!F' [Hi' Pfr:filsc"! Li\'cf'mentioning

confidence: 99%

“…Larsen et al 1979, but the effect could not be mimicked by DBcAMP in rats (Baker & Kaplan 1976) and cats (Larsen et al 1979). Shaw & Heath (1973) and Baker & Kaplan (1976) did not find any effect of glucagon on bile production in the rat and Morris eL al. (1967) reported that glucagon choleresis in the dog was accompanied by an increase in bile acid excretion.…”

Section: (!F' [Hi' Pfr:filsc"! Li\'cf'mentioning

confidence: 99%

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The effect of glucagon, dibutyrylic cyclic AMP and insulin on bile production in the intact rat and the perfused rat liver

Thomsen

Larsen

1981

Acta Physiologica Scandinavica

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The effect of glucagon, dibutyrylic cyclic AMP (DBcAMP) and insulin on bile flow and composition was studied in fasting. Nembutal anesthetized intact rats and perfused rat livers. In intact rats the infusion of glucagon (0.5 microgram x kg b.w.-1 x min-1) resulted in a parallel increase in bile flow and 14C-erythritol clearance of approx. 20%. The biliary excretion rate of electrolytes increased, whereas the net ductular fluid transport and the excretion rate of bile acids remained unchanged. Thus glucagon choleresis in intact rats appears to be due to a stimulation of the bile acid independent fraction of canalicular bile production. A similar effect was seen when DBcAMP (0.5 mumol x kg b.w.-1 x min-1) and insulin (1 U x kg b.w.-1) was given. In the perfused liver glucagon or DBcAMP also increased bile flow. However, bile acid excretion rate also increased and the rise in bile flow was proportional to the rate of taurocholate administration. This effect may be due to uneven distribution of perfusate flow. Insulin was totally without effect on bile production in the perfusion experiments. It is concluded that the choleretic effect of glucagon and insulin is dependent on unknown factors which may be related to extrahepatic actions of the hormones.

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Section: (!F' [Hi' Pfr:filsc"! Li\'cf'mentioning

confidence: 99%

Section: (!F' [Hi' Pfr:filsc"! Li\'cf'mentioning

confidence: 99%

The effect of glucagon, dibutyrylic cyclic AMP and insulin on bile production in the intact rat and the perfused rat liver

Thomsen

Larsen

1981

Acta Physiologica Scandinavica

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“…Schirmer et al, 1986), although put others have doubted that accumulation of cAMP is at physiological in bile formation(Baker & Kaplan, 1976…”

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Modulation of biliary lipid secretion by forskolin and cyclic AMP analogues

Hamlin

Rahman

Carrella

et al. 1990

Biochemical Journal

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Exposure of isolated perfused rat livers to either 100 microM-forskolin, a potent activator of adenylate cyclase, or to 0.5 mM-concentrations of the cAMP analogues chlorophenylthio cAMP (CPTcAMP), dibutyryl cAMP (dbcAMP) and 8-bromo cAMP (8BrcAMP), to provoke increases in intracellular concentrations of cAMP, resulted in marked changes in bile volume and composition. Bile flow reached a peak after 10 min, before declining towards control levels, and an increase in several secretory parameters was also observed at this time. At 20 min, a substantial decrease in the output of both phospholipid and cholesterol was evident, and this suppression of secretion was maintained throughout the remainder of the experiment. The order of effectiveness of the cAMP-elevating agents at decreasing biliary lipid output was CPTcAMP greater than forskolin greater than dbcAMP greater than 8BrcAMP. Biliary output of bile acids was essentially unaltered compared with controls; similarly, no decrease in the secretion of protein and triacylglycerols into the perfusion medium was observed. This suggests that the elevation of intracellular levels of cAMP may cause a selective inhibition of biliary lipid output rather than a more general inhibition of hepatic secretion.

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Na+/H+ exchange: What, where and why?

Dyke

Ives

1988

Hepatology

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Effects of Cholera Enterotoxin, Glucagon, and Dibutyryl Cyclic Amp on Rat Liver Alkaline Phosphatase, Bile Flow, and Bile Composition

Cited by 12 publications

References 21 publications

The effect of glucagon, dibutyrylic cyclic AMP and insulin on bile production in the intact rat and the perfused rat liver

The effect of glucagon, dibutyrylic cyclic AMP and insulin on bile production in the intact rat and the perfused rat liver

Modulation of biliary lipid secretion by forskolin and cyclic AMP analogues

Na+/H+ exchange: What, where and why?

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