Effects of cholinergic drugs on prey-killing by rodents☆

Wnek, D.J.; Leaf, Russell C.

doi:10.1016/0031-9384(73)90195-9

Cited by 28 publications

(4 citation statements)

References 13 publications

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“…This experiment had a two-fold purpose: (a) to determine whether the most effective method for inducing mouse killing in unoperated rats could also induce mouse killing by amygdala-lesioned rats and (b) if induction of killing was possible, to determine whether amygdala lesions would attenuate the inhibitory effects of d-amphetamine on mouse killing. Repeated injections of pilocarpine, a cholinomimetic drug shown to be effective with all unoperated Holtzman rats if the doses are very high (McCarthy, 1966;Vogel & Leaf, 1972;Wnek & Leaf, 1973), were used to induce mouse killing. d-Amphetamine was administered either before or immediately following a kill.…”

Section: Methodsmentioning

confidence: 99%

Interactions of amygdala lesions with effects of pilocarpine and d -amphetamine on mouse killing, feeding, and drinking in rats.

So¹

1976

Journal of Comparative and Physiological Psychology

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Repeated injections of 7.5 mg/kg pilocarpine induced mouse killing in both amygdala-lesioned and sham-operated rats, but more injections were required in the lesioned animals. Killing was evoked least readily in rats that showed substantial weight loss after surgery and that had damage to more medial regions of the amygdala. d-Amphetamine (.75, 1.50, or 3.00 mg/kg), administered either before or after a killing test, inhibited pilocarpine-induced killing in both surgical groups. Amygdala lesions attenuated pilocarpine-facilitated drinking in sated animals but did not alter the inhibitory effects of either pilocarpine or d-amphetamine on feeding or drinking.

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Section: Methodsmentioning

confidence: 99%

Interactions of amygdala lesions with effects of pilocarpine and d -amphetamine on mouse killing, feeding, and drinking in rats.

So¹

1976

Journal of Comparative and Physiological Psychology

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“…Wnek and Leaf [1973] elicited muricide in rats with systemic injections of pilocarpine. Pilocarpine can even induce muricide in non-killer rats [McCarthy, 1966;Vo gel and Leaf, 1972], However, other cholinergic ago nists, oxotremorine and methacholine were ineffective over a broad range of doses.…”

Section: Predatory Aggressionmentioning

confidence: 99%

Drugs as Research Tools in Psychology: Cholinergic Drugs and Aggression

1985

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A review of studies using cholinergic drugs as tools to investigate the neural mechanisms mediating affective and predatory aggressive behaviour reveals that the same two cholinergic systems are involved with both sorts of behaviour. There is a brain muscarinic system initiating aggression and a nicotinic system which inhibits aggressive behaviour. This evidence suggests that there could be two possible forms of cholinergic therapy for aggression, cholinolytics and nicotinic agonists. These possibilities are discussed.

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“…macologic evidence exists for cholinergic facilitation of this behavior (Bandler, 1969(Bandler, , 1970aIgic et al, 1970;Berntson and Leibowitz, 1973;Gay et al, 1976;Hoffmeister et al, 1964;Katz and Thomas, 1974;Katz, 1976a,b;McCarthy, 1966;Miczek, 1976;Smith et al, 1970;Vogel and Leaf, 1970;Wnek and Leaf, 1973) and quite possibly for serotonergic involvement in its inhibition (Sheard, 1969;Ferguson et al, 1970;DiChiara et al, 1971; note however, Valzelli and Bernasconi, 1972;Dubinsky et al, 1973;Vergneset al, 1973;Sakata et al, 1975;Miczek et a]., 1975; (NE), dopamine (DA), and possibly also epinephrine (E) (major pathways for these transmitters are shown schematically in Fig. 1) also influence the occurrence of predatory attack, the precise involvement of these systems has yet to be fully elucidated.…”

mentioning

confidence: 99%

Catecholamines in predatory behavior: A review and critique

Katz

1978

Aggr. Behav.

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A variety of strategies have been employed in assessing the role of catecholamines (CA) in predatory behavior; the results of these various approaches are reviewed. While it remains difficult to ascribe a single biologically significant role to CA at this time, this may at least in part reflect measurement considerations, problems in the widely varying experimental models, pharmacologic side effects, and failures to categorically distinguish the differing contributions of individual CA systems in the control of predation. The potential role of such factors in determining the outcome of an experiment are reviewed and possible functional contributions of CA systems are suggested.

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Effects of cholinergic drugs on prey-killing by rodents☆

Cited by 28 publications

References 13 publications

Interactions of amygdala lesions with effects of pilocarpine and d -amphetamine on mouse killing, feeding, and drinking in rats.

Interactions of amygdala lesions with effects of pilocarpine and d -amphetamine on mouse killing, feeding, and drinking in rats.

Drugs as Research Tools in Psychology: Cholinergic Drugs and Aggression

Catecholamines in predatory behavior: A review and critique

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